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Volumn 29, Issue 1, 2004, Pages 25-30

N-Acetylcysteine Administration in the ICU Patient - A Double-Edged Sword?

Author keywords

Antioxidants; ARDS; Host defence; Infection; N acetylcysteine; Sepsis

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ASCORBIC ACID; GLUTATHIONE; METAL; OXYGEN; PARACETAMOL; SELENIUM;

EID: 1542320768     PISSN: 03410501     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-812593     Document Type: Review
Times cited : (2)

References (47)
  • 2
    • 0029997657 scopus 로고    scopus 로고
    • Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk
    • Borrelli E, Roux-Lombard P, Grau GE, Girardin E, Ricou B, Dayer J, Suter PM. Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk. Crit Care Med 1996; 24: 392-397
    • (1996) Crit Care Med , vol.24 , pp. 392-397
    • Borrelli, E.1    Roux-Lombard, P.2    Grau, G.E.3    Girardin, E.4    Ricou, B.5    Dayer, J.6    Suter, P.M.7
  • 3
    • 0025934865 scopus 로고
    • N-acetylcysteine in experimental and clinical acute lung injury
    • Bernard GR. N-acetylcysteine in experimental and clinical acute lung injury. Am J Med 1991; 91: 54S-59S
    • (1991) Am J Med , vol.91
    • Bernard, G.R.1
  • 4
    • 0027144849 scopus 로고
    • Postinsult treatment with N-acetyl-L-cysteine decreases IL-1-induced neutrophil influx and lung leak in rats
    • Leff JA, Wilke CP, Hybertson BM, Shanley PF, Beehler CJ, Repine JE. Postinsult treatment with N-acetyl-L-cysteine decreases IL-1-induced neutrophil influx and lung leak in rats. Am J Physiol 1993; 265: L501-L506
    • (1993) Am J Physiol , vol.265
    • Leff, J.A.1    Wilke, C.P.2    Hybertson, B.M.3    Shanley, P.F.4    Beehler, C.J.5    Repine, J.E.6
  • 6
    • 0035025056 scopus 로고    scopus 로고
    • Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat
    • Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Ciccolo A, Centorrino T, Sarro A De, Caputi AP. Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat. FASEB J 2001; 15: 1187-1200
    • (2001) FASEB J , vol.15 , pp. 1187-1200
    • Cuzzocrea, S.1    Mazzon, E.2    Dugo, L.3    Serraino, I.4    Ciccolo, A.5    Centorrino, T.6    De Sarro, A.7    Caputi, A.P.8
  • 7
    • 0038113408 scopus 로고    scopus 로고
    • The protective effect of n-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model
    • Ozdulger A, Cinel I, Koksel O, Cinel L, Avlan D, Unlu A, Okcu H, Dikmengil M, Oral U. The protective effect of n-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model. Shock 2003; 19: 366-372
    • (2003) Shock , vol.19 , pp. 366-372
    • Ozdulger, A.1    Cinel, I.2    Koksel, O.3    Cinel, L.4    Avlan, D.5    Unlu, A.6    Okcu, H.7    Dikmengil, M.8    Oral, U.9
  • 8
    • 0030586689 scopus 로고    scopus 로고
    • In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation
    • Blackwell TS, Blackwell TR, Holden EP, Christman BW, Christman JW. In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J Immunol 1996; 157: 1630-1637
    • (1996) J Immunol , vol.157 , pp. 1630-1637
    • Blackwell, T.S.1    Blackwell, T.R.2    Holden, E.P.3    Christman, B.W.4    Christman, J.W.5
  • 9
    • 0030997422 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates endotoxin-induced leukocyte-endothelial cell adhesion and macromolecular leakage in vivo
    • Schmidt H, Schmidt W, Muller T, Bohrer H, Gebhard MM, Martin E. N-acetylcysteine attenuates endotoxin-induced leukocyte-endothelial cell adhesion and macromolecular leakage in vivo. Crit Care Med 1997; 25: 858-863
    • (1997) Crit Care Med , vol.25 , pp. 858-863
    • Schmidt, H.1    Schmidt, W.2    Muller, T.3    Bohrer, H.4    Gebhard, M.M.5    Martin, E.6
  • 10
    • 0033868382 scopus 로고    scopus 로고
    • Liposomal antioxidants provide prolonged protection against acute respiratory distress syndrome
    • Fan J, Shek PN, Suntres ZE, Li YH, Oreopoulos GD, Rotstein OD. Liposomal antioxidants provide prolonged protection against acute respiratory distress syndrome. Surgery 2000; 128: 332-338
    • (2000) Surgery , vol.128 , pp. 332-338
    • Fan, J.1    Shek, P.N.2    Suntres, Z.E.3    Li, Y.H.4    Oreopoulos, G.D.5    Rotstein, O.D.6
  • 11
    • 0021271892 scopus 로고
    • Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function
    • Bernard GR, Lucht WD, Niedermeyer ME, Snapper JR, Ogletree ML, Brigham KL. Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function. J Clin Invest 1984; 73: 1772-1784
    • (1984) J Clin Invest , vol.73 , pp. 1772-1784
    • Bernard, G.R.1    Lucht, W.D.2    Niedermeyer, M.E.3    Snapper, J.R.4    Ogletree, M.L.5    Brigham, K.L.6
  • 12
    • 0027365599 scopus 로고
    • Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells
    • Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 1993; 92: 1866-1874
    • (1993) J Clin Invest , vol.92 , pp. 1866-1874
    • Marui, N.1    Offermann, M.K.2    Swerlick, R.3    Kunsch, C.4    Rosen, C.A.5    Ahmad, M.6    Alexander, R.W.7    Medford, R.M.8
  • 13
    • 0028148369 scopus 로고
    • Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals
    • Weber C, Erl W, Pietsch A, Strobel M, Ziegler-Heitbrock HW, Weber PC. Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals. Arterioscler Thromb 1994; 14: 1665-1673
    • (1994) Arterioscler Thromb , vol.14 , pp. 1665-1673
    • Weber, C.1    Erl, W.2    Pietsch, A.3    Strobel, M.4    Ziegler-Heitbrock, H.W.5    Weber, P.C.6
  • 14
    • 0033953297 scopus 로고    scopus 로고
    • Anti-oxidants as modulators of immune function
    • La FM De, Victor VM. Anti-oxidants as modulators of immune function. Immunol Cell Biol 2000; 78: 49-54
    • (2000) Immunol Cell Biol , vol.78 , pp. 49-54
    • De La, F.M.1    Victor, V.M.2
  • 16
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1
    • Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J 1991; 10: 2247-2258
    • (1991) EMBO J , vol.10 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 17
    • 33751263666 scopus 로고    scopus 로고
    • Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression
    • Faruqi RM, Poptic EJ, Faruqi TR, La MC De, DiCorleto PE. Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression. Am J Physiol 1997; 273: H817-H826
    • (1997) Am J Physiol , vol.273
    • Faruqi, R.M.1    Poptic, E.J.2    Faruqi, T.R.3    De La, M.C.4    DiCorleto, P.E.5
  • 18
    • 0031706281 scopus 로고    scopus 로고
    • E-selectin expression in human endothelial cells by TNF-alpha-induced oxidant generation and NF-κB activation
    • Rahman A, Kefer J, Bando M, Niles WD, Malik AB. E-selectin expression in human endothelial cells by TNF-alpha-induced oxidant generation and NF-κB activation. Am J Physiol 1998; 275: L533-L544
    • (1998) Am J Physiol , vol.275
    • Rahman, A.1    Kefer, J.2    Bando, M.3    Niles, W.D.4    Malik, A.B.5
  • 20
    • 0031973672 scopus 로고    scopus 로고
    • N-acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes
    • Pahan K, Sheikh FG, Namboodiri AM, Singh I. N-acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes. Free Radic Biol Med 1998; 24: 39-48
    • (1998) Free Radic Biol Med , vol.24 , pp. 39-48
    • Pahan, K.1    Sheikh, F.G.2    Namboodiri, A.M.3    Singh, I.4
  • 21
    • 0030028401 scopus 로고    scopus 로고
    • Oxidant-antioxidant balance in granulocytes during ARDS. Effect of N-acetylcysteine
    • Laurent T, Markert M, Feihl F, Schaller MD, Perret C. Oxidant-antioxidant balance in granulocytes during ARDS. Effect of N-acetylcysteine. Chest 1996; 109: 163-166
    • (1996) Chest , vol.109 , pp. 163-166
    • Laurent, T.1    Markert, M.2    Feihl, F.3    Schaller, M.D.4    Perret, C.5
  • 22
    • 0030807230 scopus 로고    scopus 로고
    • A trial of antioxidants N-acetylcysteine and procysteine in ARDS
    • The Antioxidant in ARDS Study Group
    • Bernard GR, Wheeler AP, Arons MM, Morris PE, Paz HL, Russell JA, Wright PE. The Antioxidant in ARDS Study Group. A trial of antioxidants N-acetylcysteine and procysteine in ARDS. Chest 1997; 112: 164-172
    • (1997) Chest , vol.112 , pp. 164-172
    • Bernard, G.R.1    Wheeler, A.P.2    Arons, M.M.3    Morris, P.E.4    Paz, H.L.5    Russell, J.A.6    Wright, P.E.7
  • 23
    • 0033630492 scopus 로고    scopus 로고
    • Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome
    • Ortolani O, Conti A, Gaudio AR De, Masoni M, Novelli G. Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome. Shock 2000; 13: 14-18
    • (2000) Shock , vol.13 , pp. 14-18
    • Ortolani, O.1    Conti, A.2    De Gaudio, A.R.3    Masoni, M.4    Novelli, G.5
  • 24
    • 0034131480 scopus 로고    scopus 로고
    • The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock
    • Ortolani O, Conti A, Gaudio AR De, Moraldi E, Cantini Q, Novelli G. The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock. Am J Respir Crit Care Med 2000; 161: 1907-1911
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1907-1911
    • Ortolani, O.1    Conti, A.2    De Gaudio, A.R.3    Moraldi, E.4    Cantini, Q.5    Novelli, G.6
  • 25
    • 0031778077 scopus 로고    scopus 로고
    • Does N-acetyl-L-cysteine influence cytokine response during early human septic shock?
    • Spapen H, Zhang H, Demanet C, Vleminckx W, Vincent JL, Huyghens L. Does N-acetyl-L-cysteine influence cytokine response during early human septic shock? Chest 1998; 113: 1616-1624
    • (1998) Chest , vol.113 , pp. 1616-1624
    • Spapen, H.1    Zhang, H.2    Demanet, C.3    Vleminckx, W.4    Vincent, J.L.5    Huyghens, L.6
  • 26
    • 0028126051 scopus 로고
    • N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controlled clinical study
    • Suter PM, Domenighetti G, Schaller MD, Laverriere MC, Ritz R, Perret C. N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controlled clinical study. Chest 1994; 105: 190-194
    • (1994) Chest , vol.105 , pp. 190-194
    • Suter, P.M.1    Domenighetti, G.2    Schaller, M.D.3    Laverriere, M.C.4    Ritz, R.5    Perret, C.6
  • 27
    • 0034517906 scopus 로고    scopus 로고
    • N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: Results of a prospective, randomized, double-blind study
    • Rank N, Michel C, Haertel C, Lenhart A, Welte M, Meier-Hellmann A, Spies C. N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study. Crit Care Med 2000; 28: 3799-3807
    • (2000) Crit Care Med , vol.28 , pp. 3799-3807
    • Rank, N.1    Michel, C.2    Haertel, C.3    Lenhart, A.4    Welte, M.5    Meier-Hellmann, A.6    Spies, C.7
  • 28
    • 0026629468 scopus 로고
    • Antioxidant treatment with N-acetylcysteine during adult respiratory distress syndrome: A prospective, randomized, placebo-controlled study
    • Jepsen S, Herlevsen P, Knudsen P, Bud MI, Klausen NO. Antioxidant treatment with N-acetylcysteine during adult respiratory distress syndrome: a prospective, randomized, placebo-controlled study. Crit Care Med 1992; 20: 918-923
    • (1992) Crit Care Med , vol.20 , pp. 918-923
    • Jepsen, S.1    Herlevsen, P.2    Knudsen, P.3    Bud, M.I.4    Klausen, N.O.5
  • 30
    • 0029807263 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine depresses cardiac performance in patients with septic shock
    • Peake SL, Moran JL, Leppard PI. N-acetyl-L-cysteine depresses cardiac performance in patients with septic shock. Crit Care Med 1996; 24: 1302-1310
    • (1996) Crit Care Med , vol.24 , pp. 1302-1310
    • Peake, S.L.1    Moran, J.L.2    Leppard, P.I.3
  • 31
    • 0031460928 scopus 로고    scopus 로고
    • Treatment with N-acetylcysteine during acute respiratory distress syndrome: A randomized, double-blind, placebo-controlled clinical study
    • Domenighetti G, Suter PM, Schaller MD, Ritz R, Perret C. Treatment with N-acetylcysteine during acute respiratory distress syndrome: a randomized, double-blind, placebo-controlled clinical study. J Crit Care 1997; 12: 177-182
    • (1997) J Crit Care , vol.12 , pp. 177-182
    • Domenighetti, G.1    Suter, P.M.2    Schaller, M.D.3    Ritz, R.4    Perret, C.5
  • 32
    • 0030931428 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on tissue oxygenation in patients with multiple organ failure and evidence of tissue hypoxia
    • Agusti AG, Togores B, Ibanez J, Raurich JM, Maimo A, Bergada J, Marse P, Jorda R. Effects of N-acetylcysteine on tissue oxygenation in patients with multiple organ failure and evidence of tissue hypoxia. Eur Respir J 1997; 10: 1962-1966
    • (1997) Eur Respir J , vol.10 , pp. 1962-1966
    • Agusti, A.G.1    Togores, B.2    Ibanez, J.3    Raurich, J.M.4    Maimo, A.5    Bergada, J.6    Marse, P.7    Jorda, R.8
  • 33
    • 0027970408 scopus 로고
    • Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: Results from a prospective, randomized, double-blind study
    • Spies CD, Reinhart K, Witt I, Meier-Hellmann A, Hannemann L, Bredle DL, Schaffartzik W. Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: results from a prospective, randomized, double-blind study. Crit Care Med 1994; 22: 1738-1746
    • (1994) Crit Care Med , vol.22 , pp. 1738-1746
    • Spies, C.D.1    Reinhart, K.2    Witt, I.3    Meier-Hellmann, A.4    Hannemann, L.5    Bredle, D.L.6    Schaffartzik, W.7
  • 35
    • 0033048251 scopus 로고    scopus 로고
    • N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: A prospective, randomized, placebo-controlled study
    • Molnar Z, Shearer E, Lowe D. N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized, placebo-controlled study. Crit Care Med 1999; 27: 1100-1104
    • (1999) Crit Care Med , vol.27 , pp. 1100-1104
    • Molnar, Z.1    Shearer, E.2    Lowe, D.3
  • 36
    • 0024380927 scopus 로고
    • The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage
    • Prescott LF, Donovan JW, Jarvie DR, Proudfoot AT. The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. Eur J Clin Pharmacol 1989; 37: 501-506
    • (1989) Eur J Clin Pharmacol , vol.37 , pp. 501-506
    • Prescott, L.F.1    Donovan, J.W.2    Jarvie, D.R.3    Proudfoot, A.T.4
  • 40
    • 0035110064 scopus 로고    scopus 로고
    • N-acetylcysteine reduces respiratory burst but augments neutrophil phagocytosis in intensive care unit patients
    • Heller AR, Groth G, Heller SC, Breitkreutz R, Nebe T, Quintel M, Koch T. N-acetylcysteine reduces respiratory burst but augments neutrophil phagocytosis in intensive care unit patients. Crit Care Med 2001; 29: 272-276
    • (2001) Crit Care Med , vol.29 , pp. 272-276
    • Heller, A.R.1    Groth, G.2    Heller, S.C.3    Breitkreutz, R.4    Nebe, T.5    Quintel, M.6    Koch, T.7
  • 41
    • 0032900817 scopus 로고    scopus 로고
    • Antioxidant therapy in the prevention of organ dysfunction syndrome and infectious complications after trauma: Early results of a prospective randomized study
    • Porter JM, Ivatury RR, Azimuddin K, Swami R. Antioxidant therapy in the prevention of organ dysfunction syndrome and infectious complications after trauma: early results of a prospective randomized study. Am Surg 1999; 65: 478-483
    • (1999) Am Surg , vol.65 , pp. 478-483
    • Porter, J.M.1    Ivatury, R.R.2    Azimuddin, K.3    Swami, R.4
  • 42
    • 0015954510 scopus 로고
    • Generation of superoxide free radical during the autoxidation of thiols
    • Misra HP. Generation of superoxide free radical during the autoxidation of thiols. J Biol Chem 1974; 249: 2151-2155
    • (1974) J Biol Chem , vol.249 , pp. 2151-2155
    • Misra, H.P.1
  • 43
    • 0035037015 scopus 로고    scopus 로고
    • Redox paradox: Effect of N-acetylcysteine and serum on oxidation reduction-sensitive mitogen-activated protein kinase signaling pathways
    • Chan ED, Riches DW, White CW. Redox paradox: effect of N-acetylcysteine and serum on oxidation reduction-sensitive mitogen-activated protein kinase signaling pathways. Am J Respir Cell Mol Biol 2001; 24: 627-632
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 627-632
    • Chan, E.D.1    Riches, D.W.2    White, C.W.3
  • 44
    • 0035884859 scopus 로고    scopus 로고
    • Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise
    • Childs A, Jacobs C, Kaminski T, Halliwell B, Leeuwenburgh C. Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise. Free Radic Biol Med 2001; 31: 745-753
    • (2001) Free Radic Biol Med , vol.31 , pp. 745-753
    • Childs, A.1    Jacobs, C.2    Kaminski, T.3    Halliwell, B.4    Leeuwenburgh, C.5
  • 45
    • 0032841575 scopus 로고    scopus 로고
    • Nacetylcysteine, a cancer chemopreventive agent, causes oxidative damage to cellular and isolated DNA
    • Oikawa S, Yamada K, Yamashita N, Tada-Oikawa S, Kawanishi S. Nacetylcysteine, a cancer chemopreventive agent, causes oxidative damage to cellular and isolated DNA. Carcinogenesis 1999; 20: 1485-1490
    • (1999) Carcinogenesis , vol.20 , pp. 1485-1490
    • Oikawa, S.1    Yamada, K.2    Yamashita, N.3    Tada-Oikawa, S.4    Kawanishi, S.5
  • 47
    • 0034917560 scopus 로고    scopus 로고
    • Immunological therapy in sepsis: Currently available
    • Carlet J. Immunological therapy in sepsis: currently available. Intensive Care Med 2001; 27, Suppl 1: S93-103
    • (2001) Intensive Care Med , vol.27 , Issue.SUPPL.
    • Carlet, J.1


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