Lipid metabolism: Ceramide transfer protein adds a new dimension

Current Biology

Volumn 14, Issue 4, 2004, Pages

  Hannun, Yusuf A ^a   Luberto, Chiara ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; COL4A3BP PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SPHINGOLIPID;

CHEMICAL STRUCTURE; LIPID METABOLISM; METABOLISM; SHORT SURVEY; SIGNAL TRANSDUCTION;

CERAMIDES; LIPID METABOLISM; MODELS, MOLECULAR; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SPHINGOLIPIDS;

EID: 1542320683     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(04)00079-X     Document Type: Short Survey

References (20)

1. Levade T., Malagarie-Cazenave S., Gouaze V., Segui B., Tardy C., Betito S., Andrieu-Abadie N., Cuvillier O. Ceramide in apoptosis: a revisited role. Neurochem. Res. 27:2002;601-607.
2. Riboni L., Campanella R., Bassi R., Villani R., Gaini S.M., Martinelli-Boneschi F., Viani P., Tettamanti G. Ceramide levels are inversely associated with malignant progression of human glial tumors. Glia. 39:2002;105-113.
3. Litvak D.A., Bilchik A.J., Cabot M.C. Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategy. J. Gastrointest. Surg. 7:2003;140-148.
4. Buccoliero R., Futerman A.H. The roles of ceramide and complex sphingolipids in neuronal cell function. Pharmacol. Res. 47:2003;409-419.
5. Huwiler A., Kolter T., Pfeilschifter J., Sandhoff K. Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim. Biophys. Acta. 1485:2000;63-99.
6. Merrill A.H. Jr. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J. Biol. Chem. 277:2002;25843-25846.
7. Hiraoka M., Abe A., Shayman J.A. Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase. J. Biol. Chem. 277:2002;10090-10099.
8. Marks D.L., Wu K., Paul P., Kamisaka Y., Watanabe R., Pagano R.E. Oligomerization and topology of the Golgi membrane protein glucosylceramide synthase. J. Biol. Chem. 274:1999;451-456.
9. Gulbins E., Kolesnick R. Raft ceramide in molecular medicine. Oncogene. 22:2003;7070-7077.
10. Maceyka M., Payne S.G., Milstien S., Spiegel S. Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim. Biophys. Acta. 1585:2002;193-201.
11. Hanada K., Kumagai K., Yasuda S., Miura Y., Kawano M., Fukasawa M., Nishijima M. Molecular machinery for non-vesicular trafficking of ceramide. Nature. 426:2003;803-809.
12. Obeid L.M., Okamoto Y., Mao C. Yeast sphingolipids: metabolism and biology. Biochim. Biophys. Acta. 1585:2002;163-171.
13. van Meer G., Holthuis J.C. Sphingolipid transport in eukaryotic cells. Biochim. Biophys. Acta. 1486:2000;145-170.
14. Albi E., Viola Magni M.P. Sphingomyelin synthase in rat liver nuclear membrane and chromatin. FEBS Lett. 460:1999;369-372.
15. Luberto C., Stonehouse M.J., Collins E.A., Marchesini N., El-Bawab S., Vasil A.I., Vasil M.L., Hannun Y.A. Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme. J. Biol. Chem. 278:2003;32733-32743.
16. Huitema K., van den Dikkenberg J., Brouwers J.F.H.M., Holthuis J.C.M. Identification of a family of animal sphingomyelin synthases. EMBO J. 23:2004;33-44.
17. Hanada K., Hara T., Fukasawa M., Yamaji A., Umeda M., Nishijima M. Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin. Genetic and biochemical evidence for complex formation of the LCB1 protein with the LCB2 protein for serine palmitoyltransferase. J. Biol. Chem. 273:1998;33787-33794.
18. Pettus B.J., Chalfant C.E., Hannun Y.A. Ceramide in apoptosis: an overview and current perspectives. Biochim. Biophys. Acta. 1585:2002;114-125.
19. Fukasawa M., Nishijima M., Itabe H., Takano T., Hanada K. Reduction of sphingomyelin level without accumulation of ceramide in Chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-beta -cyclodextrin. J. Biol. Chem. 275:2000;34028-34034.
20. Van Tiel C.M., Luberto C., Snoek G.T., Hannun Y.A., Wirtz K.W. Rapid replenishment of sphingomyelin in the plasma membrane upon degradation by sphingomyelinase in NIH3T3 cells overexpressing the phosphatidylinositol transfer protein beta. Biochem. J. 346:2000;537-543.