Design of simulated moving bed units under nonideal conditions

Industrial and Engineering Chemistry Research

Volumn 38, Issue 6, 1999, Pages 2400-2410

  Migliorini, Cristiano ^a   Gentilini, Andrea ^a   Mazzotti, Marco ^a   Morbidelli, Massimo ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATOGRAPHY; COMPUTER SIMULATION; DISPERSIONS; MASS TRANSFER; MATHEMATICAL MODELS; OPTIMIZATION; PHASE EQUILIBRIA; SEPARATION;

AXIAL MIXING; EQUILIBRIUM THEORY; MASS TRANSPORT RESISTANCE; NONIDEAL CONDITIONS; SIMULATED MOVING BEDS;

FLUIDIZED BEDS;

DESIGN; DISPERSION MODELING; MOVING BED REGIME;

ARTICLE; CHEMICAL ENGINEERING; CHEMICAL REACTION; CHROMATOGRAPHY; DISPERSION; MODEL; PERFORMANCE; REACTION ANALYSIS; SIMULATION; TRANSPORT KINETICS;

EID: 0033005388     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie980262y     Document Type: Article

References (42)

1. Ruthven, D. M.; Ching, C. B. Counter current and simulated counter current adsorption separation processes. Chem. Eng. Sci. 1989, 44, 1011-1038.
2. Negawa, M.; Shoji, F. Optical resolution by Simulated Moving Bed adsorption technology. J. Chromatogr. A 1992, 590, 113-117.
3. Fuchs, G.; Nicoud, R. M.; Bailly, M. Optical isomers purification with the simulated moving bed technology: experimental and theoretical approaches. In Proceedings of Prep '92; Societè Francaise de Chemie: Nancy, France, 1992; pp 395-402.
4. Ching, C. B.; Lim, B. G.; Lee, E. J. D.; Ng, S. C. Preparative resolution of praziquantel enantiomers by simulated counter-current chromatography. J. Chromatogr. A 1993, 634, 215-219.
5. Nicoud, R. M.; Fuchs, G.; Adam, P.; Bailly, M.; Küsters, E.; Antia, F. D.; Reuille, R.; Schmid, E. Preparative scale enantio-separation of a chiral epoxide: comparison of liquid chromatography and Simulated Moving Bed adsorption technology. Chirality 1993, 5, 267-271.
6. Charton, F.; Nicoud, R. M. Complete design of a Simulated Moving Bed. J. Chromatogr. A 1995, 702, 97-112.
7. Küsters, E.; Gerber, G.; Antia, F. D. Enantioseparation of a chiral epoxide by Simulated Moving Bed chromatography using Chiralcel-OD. Chromatogr. 1995, 40, 387-393.
8. Gottschlich, N.; Weidgen, S.; Kashe, V. Continuous biospecific affinity purification of enzymes by Simulated Moving Bed chromatography. Theoretical description and experimental results. J. Chromatogr. A 1996, 719, 267-274.
9. Nagamatsu, K.; Murazumi, S.; Matsumoto, H.; Makino, S. Optical resolution of a pharmaceutical intermediate by Simulated Moving Bed. Proceedings of the Chiral Europe '96 Symposium; Spring Innovations Limited: Stokport, UK, 1997; pp 97-101.
10. Cavoy, E.; Deltent, M. F.; Lehoucq, S.; Miggiano, D. Laboratory-developed Simulated Moving Bed for chiral drug separations. Design of the system and separation of tramadol enantiomers. J. Chromatogr. A 1997, 769, 49-57.
11. Francotte, E.; Richert, J. Application of Simulated Moving Bed chromatography to the separation of the enantiomers of chiral drugs. J. Chromatogr. A 1997, 769, 101-107.
12. Guest, D. W. Evaluation of Simulated Moving Bed chromatography for pharmaceutical process development. J. Chromatogr. A 1997, 760, 159-162.
13. Pais, L. S.; Loureiro, J. M.; Rodrigues, A. E. Modeling, simulation and operation of a Simulated Moving Bed for continuous chromatographic separation of 1-1′-bi-2-naphtol enantiomers. J. Chromatogr. A 1997, 769, 25-35.
14. Pais, L. S.; Loureiro, J. M.; Rodrigues, A. E. Separation of 1-1′-bi-2-naphtol enantiomers by continuous chromatography in Simulated Moving Bed. Chem. Eng. Sci. 1997, 52, 245-257.
15. Schulte, M.; Ditz, R.; Devant, R. M.; Kinkel, J.; Charton, F. Comparison of the specific productivity of different chiral stationary phases used for Simulated Moving Bed chromatography. J. Chromatogr. A 1997, 769, 93-100.
16. Pedeferri, M. P.; Zenoni, G.; Mazzotti, M.; Morbidelli, M. Experimental analysis of a chiral separation through Simulated Moving Bed chromatography. Chem. Eng. Sci. 1999, in press.
17. Hidajat, K.; Ching, C. B.; Ruthven, D. M. Numerical simulation of a semi-continuous countercurrent adsorption unit for fructose-glucose separation. Chem. Eng. J. 1986, 33, B55-B61.
18. Storti, G.; Masi, M.; Paludetto, R.; Morbidelli, M.; Carra', S. Adsorption separation processes: countercurrent and simulated countercurrent operations. Comput. Chem. Eng. 1988, 12, 475-482.
19. Storti, G.; Masi, M.; Carra', S,; Morbidelli, M. Optimal design of multicomponent countercurrent adsorption separation processes. Chem. Eng. Sci. 1989, 44, 1329-1345.
20. Storti, G.; Mazzotti, M.; Morbidelli, M.; Carra', S. Robust design of binary countercurrent separation processes. AIChE J. 1993, 39, 471-492.
21. Mazzotti, M.; Storti, G.; Morbidelli, M. Optimal operation of Simulated Moving Bed units for nonlinear chromatographic separations. J. Chromatogr. A 1997, 769, 3-24.
22. Gentilini, A.; Migliorini, C.; Mazzotti, M.; Morbidelli, M. Optimal operation of Simulated Moving Bed units for non-linear chromatographic separations. II Bi-langmuir isotherms. J. Chromatogr. A 1998, 805, 37-44.
23. Storti, G.; Baciocchi, R.; Mazzotti, M.; Morbidelli, M. Design of optimal operating conditions of Simulated Moving Bed adsorptive separation units. Ind. Eng. Chem. Res. 1995, 34, 288-301.
24. Mazzotti, M.; Baciocchi, R.; Storti, G.; Morbidelli, M. Vapor-phase Simulated Moving Bed adsorptive separation of linear/nonlinear paraffins. Ind. Eng. Chem. Res. 1996, 35, 2313-2321.
25. Storti, G.; Masi, M.; Morbidelli, M. Modeling of counter-current adsorption processes. In Ganetsos, G., Barker, P. E., Eds.; Marcel Dekker: New York. 1993; Preparative and production scale chromatography; pp 673-700.
26. Yun, T.; Bensetiti, Z.; Zhong, G.; Guiochon, G. Effect of column efficiency on the internal profiles and the performance of a Simualted Moving Bed unit in the case of a linear isotherm. J. Chromatogr. A 1997, 758, 175-190.
27. Yun, T.; Zhong, G.; Guiochon, G. Simulated Moving Bed under linear conditions: experimental vs. calculated results. AIChE J. 1997, 43, 935-945.
28. Mazzotti, M.; Storti, G.; Morbidelli, M. Shock layer analysis in multicomponent chromatography and countercurrent adsorption. Chem. Eng. Sci. 1994, 49, 1337-1355.
29. Rodrigues, A. E.; Loureiro, J. M.; Lu, Z. P.; Pais, L. S. Modeling and operation of a Simulated Moving Bed for the separation of optical isomers. In Fundamentals of Adsorption; LeVan, M. D., Ed.; Kluwer Academic Publishers: 1996; pp 765-772.
30. Pais, L. S.; Loureiro, J. M.; Rodrigues, A. E. Modeling strategies for enantiomers separation by S M B chromatography. AIChE J. 1998, 44, 561-569.
31. Ruthven, D. M. Principles of adsorption and adsorption processes; John Wiley: New York, 1984.
32. Morbidelli, M.; Servida, A.; Storti, G.; Carra', S. Simulation of multicomponent adsorption beds. Model analysis and numerical solution. Ind. Eng. Chem. Fundamen. 1982, 21, 123-133.
33. Guiochon, G.; Golshan-Shirazi, S.; Katti, A. M. Fundamentals of preparative and nonlinear chromatography; Academic Press: Boston, 1994.
34. Heuter, C.; Küsters, E.; Plattner, T.; Seidel-Morgenstern, A. Design of the simulated moving bed process based on adsorption isotherm measurements using a perturbation method. J. Chromatogr. A 1998, 827, 175-191.
35. LeVan, D. M.; Carta, G.; Yon, C. Adsorption and ion exchange. In Perry's Chemical Engineers' Handbook; Perry, R. H., Green, D. W., Eds.; McGraw-Hill: New York, 1997.
36. Seidel-Morgenstern, A.; Guiochon, G. Modeling of the competitive isotherms and the chromatographic separation of two enantiomers. Chem. Eng. Sci. 1993, 48, 2787-2797.
37. Seidel-Morgenstern, A.; Jacobson, S. C.; Guiochon, G. Study of band broadening in enantioselective separations using microcrystalline cellulose triacetate. II Frontal analysis. J. Chromatogr. A 1993, 637, 19-28.
38. Mazzotti, M.; Neri, B.; Gelosa, D.; Morbidelli, M. Dynamics of a chromatographic reactor: esterification catalyzed by acidic resins. Ind. Eng. Chem. Res. 1997, 36, 3163-3172.
39. Francotte, E.; Richert, J.; Mazzotti, M.; Morbidelli, M. Simulated Moving Bed chromatographic resolution of racemic guaifenesin. J. Chromatogr. A 1998, 796, 239-248.
40. Helferrich, H.; Klein, R. Multicomponent chromatography; Marcel Dekker: New York, 1971.
41. Rhee, H.-K.; Aris, R.; Amundson, N. R. First order partial differential equations, Volume 2; Prentice-Hall: Englewood Cliffs, NJ, 1986.
42. Migliorini, C.; Gentilini, A.; Mazzotti, M.; Morbidelli, M. Robust design of binary countercurrent separation processes 5. Non-constant selectivity binary systems. AIChE J. 1999, submitted for publication.