Dynamic simulation of simulated moving-bed chromatographic processes for the optimization of chiral separations

Journal of Chromatography A

Volumn 769, Issue 1, 1997, Pages 81-92

  Strube, J ^a   Altenhoner U ^a   Meurer, M ^a   Schmidt Traub, H ^a   Schulte, M ^b  

^a TU DORTMUND UNIVERSITY   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

Adsorption isotherms; Computer simulation; Enantiomer separation; Optimization; Preparative chromatography; Simulated moving bed chromatography

Indexed keywords

5 [1 (3,4 DIMETHOXYBENZOYL) 1,2,3,4 TETRAHYDRO 6 QUINOLYL] 3,6 DIHYDRO 6 METHYL 2H 1,3,4 THIADIAZIN 2 ONE;

ARTICLE; CHROMATOGRAPHY; COMPUTER SIMULATION; DOSE RESPONSE; DRUG PURIFICATION; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; RACEMIC MIXTURE; TECHNIQUE; THEORY;

EID: 0342275249     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(97)00236-7     Document Type: Article

References (16)

1. Broughton D.B. Chem. Eng. Prog. 64:1968;60-65.
2. K. Unger (Editor), Handbuch der HPLC, Teil 2, GIT Verlag, Darmstadt, 1994.
3. G. Guiochon, S. Golshan_shirazi, M. Katti, Fundamentals of Preparative and Nonlinear Chromatography, Academic Press, Boston, MA, 1994.
4. Strube J., Paul H.-I., Schmidt-Traub H. Chem.-Ing.-Tech. 67:1995;323-326.
5. Strube J., Schmidt-Traub H. Computers Chem. Eng. 20(Suppl.):1996;S641-646.
6. Ruthven D.M., Ching C.B. Chem. Eng. Sci. 44:1989;1011-1038.
7. Storti G., Masi M., Carrà S., Morbidelli M. Chem. Eng. Sci. 44:1989;1329-1345.
8. Storti G., Mazzotti M., Morbidelli M., Carrà S. AIChE J. 39:1993;471-492.
9. Schulte M., Kinkel J.N., Nicoud R.-M., Charton F. Chem.-Ing.-Tech. 68:1996;670-683.
10. J. Strube, U. Altenhöner, M. Meurer and H. Schmidt-Traub, Chem.-Ing.-Tech., 69 (1997) 3.
11. U. Altenhöner, M. Meurer, J. Strube, H. Schmidt-Traub, J. Chromatogr. A, 769 (1997) in press.
12. Fornstedt T., Zhong G., Guiochon G. J. Chromatogr. A. 742:1996;55-68.
13. M. Schulte, R.M. Devant, A. Keil, F. Charton, Chiral Europe Proceedings, Edinburgh, 1996, in press.
14. D.M. Ruthven, Principles of Adsorption and Adsorption Processes, Wiley, New York, 1984.
15. Lim B.-G., Tan R.B.-H., Ching C.B. Sep. Technol. 5:1995;213-228.
16. Nicoud R.M. LC·GC Int. 5:1992;43-47.