Pulsatile local delivery of thrombolytic and antithrombotic agents using poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels

Journal of Controlled Release

Volumn 39, Issue 1, 1996, Pages 57-64

  Brazel, Christopher S ^a   Peppas, Nikolaos A ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Heparin; Hydrogel; pH sensitivity; Streptokinase; Temperature sensitivity

Indexed keywords

ANTICOAGULANT AGENT; COPOLYMER; ETHYLENE GLYCOL DIMETHACRYLATE; FIBRINOLYTIC AGENT; HEPARIN; METHACRYLIC ACID; N ISOPROPYLACRYLAMIDE; N ISOPROPYLACRYLAMIDE METHACRYLIC ACID COPOLYMER; STREPTOKINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SYNTHESIS; HYDROGEL; PH; PHARMACEUTICS; PRIORITY JOURNAL; TEMPERATURE;

EID: 0029875145     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(95)00134-4     Document Type: Article

References (24)

1. R.W. Baker, Controlled Release of Biologically Active Agents, John Wiley and Sons, New York, 1987, pp. 75-78, 179-183.
2. A. Hoffman, Conventional and environmentally-sensitive hydrogels for medical and industrial uses: a review paper, ACS Polym. Preprints 31 (1991) 289-297.
3. M.T. am Ende, D. Hariharan and N.A. Peppas, Factors influencing drug and protein transport and release from ionic hydrogels, Reactive Polym. 25 (1995) 127-137.
4. D. Collen and H.K. Gold, New developments in thrombolytic therapy, in: C.Y. Liu and S. Chien (Eds), Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis, Plenum Press, New York, 1990, pp. 333-353.
5. E. Rapaport, Thrombolytic agents in acute myocardial infarction, N. Engl. J. Med. 320 (1989) 861-863.
6. M. Heskins and J.E. Guillet, Solution properties of poly(N-isopropylacrylamide), J. Macromol. Sci.-Chem. A2 (1968) 1441-1455.
7. C.K. Chiklis and J.M. Grasshoff, Swelling of thin films. I. acrylamide-N-isopropylacrylamide copolymers in water, J. Polym. Sci. A-2 (1970) 1617-1626.
8. R.F.S. Frietas and E.L. Cussler, Temperature sensitive gels as extraction solvents, Chem. Eng. Sci. 42 (1987) 97-103.
9. S. Ito, Phase transition of aqueous solution of poly(N-alkylacrylamide) derivatives - effects of side chain structure, Kobunshi Ronbunshu 46 (1989) 437-443.
10. A.M. Weiss, K.P. Adler, A.J. Grodzinsky and M.L. Yarmush, Variable permeability membranes, network structure of poly(methacrylic acid) and its relation to diffusive transport, J. Membr. Sci. 58 (1991) 153-173.
11. M. Seno, M.L. Len and K. Iwamoto, Swelling of poly(methacrylic acid) gels and adsorption of L-lysine and its polymer on the gels, Colloid Polym. Sci., 269 (1991) 873-879.
12. J. Klier, A.B. Scranton, and N.A. Peppas, Self-associating networks of poly(methacrylic acid-g-ethylene glycol), Macromolecules 23 (1990) 4944-4949.
13. Y.-H. Kim, Y.H. Bae and S.W. Kim, pH/temperature-sensitive polymers for macromolecular drug loading and release, J. Control. Release 28 (1994) 143-152.
14. A. Gutowska, Y.H. Bae, J. Feijen and S.W. Kim, Heparin release from thermosensitive hydrogels, J. Control. Release 22 (1992) 95-104.
15. K. Mukae, Y.H. Bae, T. Okano and S.W. Kim, A new thermo-sensitive hydrogel: poly(ethylene oxide-dimethyl siloxane-ethylene oxide)/poly(N-isopropylacrylamide) interpenetrating polymer networks: II. On-off regulation of solute release from thermo-sensitive hydrogel, Polym. J. 22 (1990) 250-265.
16. R. Yoshida, K. Sakai, T. Okano and Y. Sakurai, Drug release profiles in the shrinking process of thermoresponsive poly(N-isopropylacrylamide-co-alkyl methacrylate) gels, Ind. Eng. Chem. Res. 31 (1992) 2339-2345.
17. R. Yoshida, K. Sakai, T. Okano and Y. Sakurai, Surface-modulated skin layers of thermal responsive hydrogels as on-off switches: II. Drug permeation, J. Biomater. Sci. Polym. Edn., 3 (1992) 243-252.
18. L.-C. Dong and A.S. Hoffman, A novel approach for preparation of pH-sensitive hydrogels for enteric drug delivery, J. Control. Release 15 (1991) 141-152.
19. H. Feil, Y.H. Bae, J. Feijen and S.W. Kim, Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers, Macromolecules 26 (1993) 2496-2500.
20. C.S. Brazel and N.A. Peppas, Synthesis and characterization of thermo-and chemo-mechanically responsive poly(N-isopropyl acrylamide-co-methacrylic acid) hydrogels, Macromolecules 28 (1995) 8016-8020.
21. N.A. Peppas, H.J. Moynihan and L.M. Lucht, The structure of highly crosslinked poly(2-hydroxyethyl methacrylate) hydrogels, J. Biomed. Mater. Res. 19 (1985) 397-411.
22. P.J. Flory, Principles of Polymer Chemistry, Cornell University Press, Ithaca, NY, 1953.
23. N.A. Peppas and E.W. Merrill, Poly(vinyl alcohol) hydrogels: reinforcement of radiation-crosslinked networks by crystallization, J. Polym. Sci. Polym. Chem. Ed. 14 (1976) 441-457.
24. A.E. Lewis, Principles of Hematology, Appleton-Century-Crofts, New York, 1970, p. 36.