Interpretation of NMR relaxation properties of Pin1, a two-domain protein, based on Brownian dynamic simulations

Journal of Biomolecular NMR

Volumn 29, Issue 1, 2004, Pages 21-35

  Bernadó, Pau ^a,e   Fernandes, Miguel X ^b   Jacobs, Doris M ^c   Fiebig, Klaus ^c,d   García de la Torre, José ^b   Pons, Miquel ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

^c GOETHE UNIVERSITY   (Germany)

^d Affinium Pharmaceuticals   (Canada)

^e INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Brownian dynamics; Multi domain proteins; NMR relaxation; Protein flexibility; Reorientational mode dynamics; Separation of global and local motions

Indexed keywords

CYCLOPHILIN; PEPTIDYLPROLYL ISOMERASE PIN1; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; HYDRODYNAMICS; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; SENSITIVITY ANALYSIS; SIMULATION; STANDARDIZATION; STOCHASTIC MODEL; TIME; VALIDATION PROCESS;

EID: 1542285877     PISSN: 09252738     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:JNMR.0000019499.60777.6e     Document Type: Article

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