STAT1 binds to the herpes simplex virus type 1 latency-associated transcript promoter

Journal of NeuroVirology

Volumn 10, Issue 1, 2004, Pages 12-20

  Kriesel, John D ^a   Jones, Brandt B ^a   Dahms, Kimberly M ^a   Spruance, S L ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Herpes simplex virus; HSV; Latency; Reactivation; Signal transducers and activators of transcription

Indexed keywords

CYTOKINE; OLIGONUCLEOTIDE; PROTEIN ANTIBODY; STAT1 PROTEIN; STAT3 PROTEIN; STAT5A PROTEIN; TATA BINDING PROTEIN;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DELETION MUTANT; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; IN VIVO STUDY; INCUBATION TIME; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TATA BOX; TRANSCRIPTION INITIATION; TRIGEMINUS GANGLION; VIRUS REACTIVATION;

ANIMALS; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 1, HUMAN; MICE; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TATA BOX; TRANS-ACTIVATORS; TRIGEMINAL GANGLION; VIRAL PROTEINS; VIRUS ACTIVATION; VIRUS LATENCY;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 1542285275     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280490261680     Document Type: Article

References (39)

1. Ackland-Berglund C, Davido D, Leib D (1995). The roles of cAMP-response element and TATA box expression of the HSV-1 LATs. Virology 210:141-151.
2. Ahmed M, Lock M, Miller CG, Fraser NW (2002). Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo. J Virol 76: 717-729.
3. Akira S, Nishio Y, Tanaka T, Inoue M, Matsusaka. T, Wang XJ, Wei S, Yoshida N, Kishimoto T (1995).Transcription factors NF-IL-6 and APRF are involved in gp130-mediated signaling pathway. Ann N Y Acad Sci 762: 15-28.
4. Block T, Hill J (1997). The latency associated transcripts (LAT) of herpes simplex virus: still no end in sight. J Neuro Virol 3: 313-321.
5. Bloom D, Devi-Rao G, Hill J, Stevens J, Wagner E (1994). Molecular analysis of HSV-1 during, epinephrine induced reactivation of latently infected rabbits in vivo. J Virol 68:1283-1292.
6. Cantin E, Tanamachi B, Openshaw H (1999). Role for gamma interferon in control of HSV-1 reactivation. J Virol 73: 3418-3423.
7. Chatterjee-Kishore M, VanDenAkker F, Stark J (2000). Association of STATs with relatives and friends. Trends Cell Biol 10: 106-111.
8. Chen X, Schmidt MC, Goins WF, Glorioso JC (1995). Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections. J Virol 69: 7899-7908.
9. Dawson C (1995). Management of herpes simplex eye diseases. In: Clinical management of herpes viruses, Vol. 1. Sacks SL, Strauss SE, Whitley RJ, Griffiths PD (eds). Amsterdam: IOS Press, pp 127-136.
10. Dobson A, Margolis T, Gomes W, Feldman L (1995). In vivo deletion analysis of the HSV-1 LAT promoter. J Virol 69: 2264-2270.
11. Drolet BS, Perng GC, Slanina SM, Yukht A, Nesburn AB, Wechsler SL (1998). The region of HSV-1 LAT gene involved in spontaneous reactivation does not encode a functional protein. Virology 242: 221-232.
12. Fraser NW, Block TM, Spivack JG (1992). The latency-associated transcripts of HSV. RNA in search of function. Virology 191: 1-8.
13. Halford WP, Gebhardt BM, Carr DJ (1996). Mechanisms of herpes simplex virus type 1 reactivation. J Virol 70: 5051-5060.
14. Henderson G, Peng W, Jin L, Perng G, Nesburn A, Wechsler S, Jones C (2002). Regulation of caspase 8 and caspase 9-induced apoptosis by the HSV-1 LAT. J NeuroVirol 8 (suppl 2): 103-111.
15. Hendricks RL, Tumpey TM, Finnegan A (1992). IFN-gamma and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice. J Immunol 149: 3023-3028.
16. Hendricks RL, Weber PC, Taylor JL, Koumbis A, Tumpey TM, Glorioso JC (1991). Endogenously produced interferon alpha protects mice from herpes simplex virus type 1 corneal disease. J Gen Virol 72: 1601-1610.
17. Hill JM, Sedarati F, Javier RT, Wagner EK, Stevens JG (1990). Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology 174: 117-125.
18. Kriesel J, Jones B, Hwang I, Dahms K, Spruance S (2001). Signal transducers and activators of transcription (STATs) are detectable in mouse trigeminal ganglion neurons. J Interferon Cytokine Res 21: 445-450.
19. Kriesel J, Ricigliano J, Spruance S, Garza H, Hill J (1998). Neuronal reactivation of herpes simplex virus may involve interleukin-6. J NeuroVirol 3: 441-448.
20. Kriesel JD, Araneo BA, Petajan JP, Spruance SL, Stromatt S (1994). Herpes labialis associated with recombinant human ciliary neurotrophic factor. J Infect Dis 170: 1046.
21. Kriesel JD, Gebhardt BM, Hill JM, Maulden SA, Hwang IP, Clinch TE, Cao X, Spruance SL, Araneo BA (1997). Anti-Interleukin-6 antibodies inhibit herpes simplex virus reactivation. J Infect Dis 175: 821-827.
22. Laycock KA, Lee SF, Brady RH, Pepsose JS (1991). Characterization of a murine model of recurrent HSV keratitis induced by ultraviolet B radiation. Invest Ophthamol Vis Sci 32: 2741-2746.
23. Mador N, Goldenberg D, Cohen O, Panet A, Steiner I (1998). HSV-1 LAT's suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line. J Virol 72: 5067-5075.
24. McGeouch DJ, Dalrymple MA, Davison AJ, Dolan A, Frame MC, McNab D, Perry LJ, Scott JE, Taylor P (1988). The complete DNA sequence of the long unique region in the genome of HSV-1. J Gen Virol 69: 1531.
25. McKenzie RC, Sander DN (1994). Ultraviolet radiation: effects on the immune system. Ann RCPSC 27: 20-26.
26. Perng G, Jones C, Ciacci-Zanella J, Stone M, Henderson G, Yukht A, Slanina S, Hofman F, Ghiasi H, Nesburn A, Wechsler S (2000a). Virus-induced neuronal apoptosis blocked by HSV LAT. Science 287: 1500-1503.
27. Perng G, Slanina S, Nesburn A, Wechsler S (1996). The spontaneous reactivation function of the HSV-1 LAT gene resides completely within the first 1.5 kilobases of the 8.3 kilobase primary transcript. J Virol 70: 976-984.
28. Perng G, Slanina S, Yukht A, Ghiasi H, Nesburn A, Wechsler S (2000b). The LAT gene enhances establishment of HSV-1 latency in rabbits. J Virol 74: 1885-1891.
29. Perng GC, Dunkel EC, Geary PA, Slanina SM, Ghiasi H, Kaiwar R, Nesburn AB, Wechsler SL (1994). The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency. J Virol 68: 8045-8055.
30. Perng GC, Maguen B, Jin L, Mott KR, Osorio N, Slanina SM, Yukht A, Ghiasi H, Nesburn AB, Inman M, Henderson G, Jones C, Wechsler SL (2002). A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. J Virol 76: 1224-1235.
31. Rajan P, Gearan T, Fink J (1998). LIF and NGF regulate STAT activation in sympathetic ganglia: convergence of cytokine- and neurotrophin-signaling pathways. Brain Res 802: 198-204.
32. Sawtell NM (1998). The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia. J Virol 72: 6888-6892.
33. Sawtell NM, Poon DK, Tansky CS, Thompson RL (1998). The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation. J Virol 72: 5343-5350.
34. Schindler C, Darnell J (1995). Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64: 621-651.
35. Spruance SL (1995). Herpes simplex labialis. In: Clinical management of herpes viruses, Vol. 1. Sacks SL, Strauss SE, Whitley RJ, Griffiths PD (eds). Amsterdam: IOS Press, pp 3-42.
36. Stevens JG (1990). Transcripts associated with herpes simplex virus latency. Adv Exp Med Biol 278: 199-204.
37. Thomas S, Gough G, Latchman D, Coffin R (1999). HSV LAT encodes a protein which greatly enhances virus growth, can compensate for deficiencies in IE gene expression, and is likely to function during reactivation from viral latency. J Virol 73: 6618-6625.
38. Thomas S, Lilley C, Latchman D, Coffin R (2002). A protein encoded by the HSV-1 2 kb LAT transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted in the quiescent HSV genome. J Virol 76: 4056-4067.
39. Zwaagstra JC, Ghiasi H, Nesburn AB, Wechsler SL (1991). Identification of a major regulatory sequence in the LAT promoter of HSV-1. Virology 182: 287-297.