Modifying the specificity and activity of the Enterobacter cloacae P99 β-lactamase by mutagenesis within an M13 phage vector

Biochemistry

Volumn 35, Issue 7, 1996, Pages 2104-2111

  Siemers, Nathan O ^a   Yelton, Dale E ^a   Bajorath, Jürgen ^a   Senter, Peter D ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CEFALORAM; CEPHALOSPORIN DERIVATIVE; DOXORUBICIN; MUTANT PROTEIN; NITROCEFIN;

ARTICLE; BACTERIAL GENE; BACTERIOPHAGE; BACTERIUM MUTANT; CANCER CHEMOTHERAPY; CYTOTOXICITY; DRUG METABOLISM; ENTEROBACTER CLOACAE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; MICHAELIS MENTEN KINETICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL;

BACTERIOPHAGE M13; BASE SEQUENCE; BETA-LACTAMASES; CATALYSIS; CELL SURVIVAL; DNA PRIMERS; ENTEROBACTER CLOACAE; GENETIC VECTORS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0030044332     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9514166     Document Type: Article

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