메뉴 건너뛰기




Volumn 74, Issue 20, 2004, Pages 2527-2539

Glucuronidation of haloperidol by rat liver microsomes: Involvement of family 2 UDP-glucuronosyltransferases

Author keywords

Glucuronidation; Haloperidol; HPLC; Rat liver microsomes; UGT isoforms

Indexed keywords

BETA GLUCURONIDASE; GLUCURONOSYLTRANSFERASE; HALOPERIDOL; ISOENZYME; URIDINE DIPHOSPHATE GLUCURONIC ACID;

EID: 1542268887     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.10.009     Document Type: Article
Times cited : (8)

References (21)
  • 2
    • 0023069599 scopus 로고
    • Heterogeneity of hepatic microsomal UDP-glucuronosyltransferases activities: Use and comparison of differential inductions in some mammalian species
    • Boutin J.A., Antoine B., Fournel-Gigleux S., Siest G. Heterogeneity of hepatic microsomal UDP-glucuronosyltransferases activities: use and comparison of differential inductions in some mammalian species. Comparative Biochemistry and Physiology. 87B(3):1987;513-522.
    • (1987) Comparative Biochemistry and Physiology , vol.87 , Issue.3 , pp. 513-522
    • Boutin, J.A.1    Antoine, B.2    Fournel-Gigleux, S.3    Siest, G.4
  • 3
    • 0029126205 scopus 로고
    • Expression and distribution of cholesterol 7 alpha-hydroxylase in rat liver
    • Brassil P.J., Edwards R.J., Davies D.S. Expression and distribution of cholesterol 7 alpha-hydroxylase in rat liver. Biochemical Pharmacology. 50(3):1995;311-316.
    • (1995) Biochemical Pharmacology , vol.50 , Issue.3 , pp. 311-316
    • Brassil, P.J.1    Edwards, R.J.2    Davies, D.S.3
  • 4
    • 0002665284 scopus 로고    scopus 로고
    • Transformation Reactions: Glucuronidation
    • T.F. Woolf. New York: Marcel Dekker
    • Burchell B. Transformation Reactions: Glucuronidation. Woolf T.F. Handbook of Drug Metabolism. 1997;Marcel Dekker, New York.
    • (1997) Handbook of Drug Metabolism
    • Burchell, B.1
  • 5
    • 0037223551 scopus 로고    scopus 로고
    • Genetic variation of human UDP-glucuronosyltransferase: Implications in disease and drug glucuronidation
    • Burchell B. Genetic variation of human UDP-glucuronosyltransferase: implications in disease and drug glucuronidation. American Journal of Pharmacogenomics. 3(1):2003;37-52.
    • (2003) American Journal of Pharmacogenomics , vol.3 , Issue.1 , pp. 37-52
    • Burchell, B.1
  • 8
    • 0024833864 scopus 로고
    • The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation
    • Iyanagi T., Watanabe T., Uchiyama Y. The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation. Journal of Biological Chemistry. 264(35):1989;21304-21307.
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.35 , pp. 21304-21307
    • Iyanagi, T.1    Watanabe, T.2    Uchiyama, Y.3
  • 9
    • 0026335219 scopus 로고
    • Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat)
    • Iyanagi T. Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat). Journal of Biological Chemistry. 266(35):1991;24048-24052.
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.35 , pp. 24048-24052
    • Iyanagi, T.1
  • 10
    • 0036178106 scopus 로고    scopus 로고
    • Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases
    • Kessler F.K., Kessler M.R., Auyeung D.J., Ritter J.K. Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Drug Metab. Dispos. 30(3):2002;324-330.
    • (2002) Drug Metab. Dispos. , vol.30 , Issue.3 , pp. 324-330
    • Kessler, F.K.1    Kessler, M.R.2    Auyeung, D.J.3    Ritter, J.K.4
  • 11
    • 0037324354 scopus 로고    scopus 로고
    • Serotonin (5-hydroxytryptamine) glucuronidation in vitro: Assay development, human liver microsome activities and species differences
    • Krishnaswamy S., Duan S.X., Von Moltke L.L., Greenblatt D., Court M.H. Serotonin (5-hydroxytryptamine) glucuronidation in vitro: assay development, human liver microsome activities and species differences. Xenobiotica. 33(2):2003;169-180.
    • (2003) Xenobiotica , vol.33 , Issue.2 , pp. 169-180
    • Krishnaswamy, S.1    Duan, S.X.2    Von Moltke, L.L.3    Greenblatt, D.4    Court, M.H.5
  • 12
    • 0038685671 scopus 로고    scopus 로고
    • Validation of Serotonin (5-Hydroxtryptamine) as an in Vitro Substrate Probe for Human UDP-Glucuronosyltransferase (UGT) 1A6
    • Krishnaswamy S., Duan S.X., Von Moltke L.L., Greenblatt D., Court M.H. Validation of Serotonin (5-Hydroxtryptamine) as an in Vitro Substrate Probe for Human UDP-Glucuronosyltransferase (UGT) 1A6. Drug Metab and Disposition. 31(1):2003;133-139.
    • (2003) Drug Metab and Disposition , vol.31 , Issue.1 , pp. 133-139
    • Krishnaswamy, S.1    Duan, S.X.2    Von Moltke, L.L.3    Greenblatt, D.4    Court, M.H.5
  • 13
    • 0033392246 scopus 로고    scopus 로고
    • Pharmacokinetics of haloperidol: An update
    • Kudo S., Ishizaki T. Pharmacokinetics of haloperidol: an update. Clinical Pharmacokinetics. 37(6):1999;435-456.
    • (1999) Clinical Pharmacokinetics , vol.37 , Issue.6 , pp. 435-456
    • Kudo, S.1    Ishizaki, T.2
  • 14
    • 0020482769 scopus 로고
    • Functional heterogeneity of UDP-glucuronosyltransferase activities in C57BL/6 and DBA/2 mice
    • Lilienblum W., Walli A.K., Bock K.W. Functional heterogeneity of UDP-glucuronosyltransferase activities in C57BL/6 and DBA/2 mice. Biochemical Pharmacology. 31(6):1982;907-913.
    • (1982) Biochemical Pharmacology , vol.31 , Issue.6 , pp. 907-913
    • Lilienblum, W.1    Walli, A.K.2    Bock, K.W.3
  • 15
    • 0023655381 scopus 로고
    • Rat liver UDP-glucuronosyltransferase: Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and beta-estradiol
    • Mackenzie P.I. Rat liver UDP-glucuronosyltransferase: Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and beta-estradiol. Journal of Biological Chemistry. 262(24):1987;9744-9749.
    • (1987) Journal of Biological Chemistry , vol.262 , Issue.24 , pp. 9744-9749
    • MacKenzie, P.I.1
  • 17
    • 0028044817 scopus 로고
    • A recombinant phenobarbital- inducible rat liver UDP- glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids
    • Pritchard M., Fournel-Gigleux S., Siest G., Mackenzie P., Magdalou J. A recombinant phenobarbital- inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids. Molecular Pharmacology. 45(1):1994;42-50.
    • (1994) Molecular Pharmacology , vol.45 , Issue.1 , pp. 42-50
    • Pritchard, M.1    Fournel-Gigleux, S.2    Siest, G.3    MacKenzie, P.4    Magdalou, J.5
  • 20
    • 0026638785 scopus 로고
    • Haloperidol metabolism in psychiatric patients: Importance of glucuronidation and carbonyl reduction
    • Someya T., Shibasaki M., Noguchi T., Takahashi S., Inaba T. Haloperidol metabolism in psychiatric patients: importance of glucuronidation and carbonyl reduction. Journal of Clinical Psychopharmacology. 12(3):1992;169-174.
    • (1992) Journal of Clinical Psychopharmacology , vol.12 , Issue.3 , pp. 169-174
    • Someya, T.1    Shibasaki, M.2    Noguchi, T.3    Takahashi, S.4    Inaba, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.