Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse

Experimental and Molecular Medicine

Volumn 37, Issue 1, 2005, Pages 65-69

  Jahng, Jeong Won ^a   Choi, Si Ho ^a   Cha, Mi Joo ^a   Kim, Nam Youl ^a   Hwang, Soon Jeong ^b   Lee, Jong Ho ^b  

^a Yonsei University College of Medicine   (South Korea)

^b School of Dentistry   (South Korea)

Author keywords

Depression; Gene expression; In situ hybridization; Leptin; Serotonin; Tumor

Indexed keywords

LEPTIN; MESSENGER RNA; SEROTONIN TRANSPORTER;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; GENE EXPRESSION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; MALE; MOUSE; MOUTH CARCINOMA; NONHUMAN; RADIOIMMUNOASSAY; SQUAMOUS CELL CARCINOMA;

EID: 15344350156     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2005.9     Document Type: Article

References (24)

1. Brown RR, Lee MC, Kohler PC, Hank JA, Storer BE, Sondel PM. Altered tryptophan and neopterin metabolism in cancer patients treated with recombinant interleukin-2. Cancer Res 1989;49:4941-4
2. Brown RR, Ozaki Y, Datta SP, Borden EC, Sondel PM, Malone DG. Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS. Adv Exp Med Biol 1991;294:425-35
3. Calapai G, Corica F, Corsonello A, Sautebin L, Di Rosa M, Campo GM, Buemi M, Mauro VN, Caputi AP. Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis. J Clin Invest 1999;104:975-82
4. Capuron L, Ravaud A, Neveu PJ, Miller AH, Maes M, Dantzer R. Association between decreased serum tryptophan concentraions and depressive synptoms in cancer patients undergoing cytokine therapy. Mol Psychiatry 2002;7:468-73
5. Choi SH, Kwon BS, Lee S, Houpt TA, Lee HT, Kim DG, Jahng JW. Systemic 5-hydroxy-L-tryptophan down-regulates the arcuate CART mRNA level in rats. Regul Pept 2003;115: 73-80
6. Collin M, Hakansson-Ovesjo M-L, Misane I, Ogren SO, Meister B. Decreased 5-HT transporter mRNA in neurons of the dorsal raphe nucleus and behavioral depression in the obese leptin-deficient ob/ob mouse. Mol Brain Res 2000;81: 51-61
7. Fernandez-Galaz MC, Diano S, Horvath TL, Garcia-Segura LM. Leptin uptake by serotonergic neurons of the dorsal raphe. J. Neuroendocrinol. 2002;14:429-34
8. Finn PD, Cunningham MJ, Richard DG, Clifton DK, Steiner RA. Serotonergic neurons are targets for leptin in the monkey. J Clin Endocrinol Metab 2001;86:422-6
9. Fruhbeck G, Jebb SA, Prentice AM. Leptin: physiology and pathophysiology. Clin Physiol 1998;18:399-419
10. Goodwin JS, Zhang DD, Ostir GV. Effect of depression on diagnosis, treatment, and survival of older women with breast cancer. J Am Geriatr Sol 2004;52:106-11
11. Gorman JM, Kent JM, SSRIs and SMRIs: Broad spectrum of efficacy beyond major depression. J Clin Psychiatry 1999; 60:33-8
12. Harris RB, Zhou J, Redmann SM Jr, Smagin GN, Smith SR, Rodgers E, Zachwieja JJ. A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology 1998;139: 8-19
13. Hay-Schmidt A, Helboe L, Larsen PJ. Leptin receptor immunoreactivity is present in ascending serotonergic and catecholaminergic neurons of the rat. Neuroendocrinology 2001;73:215-26
14. Jahng JW, Houpt TA, Joh TH, Son JH. Differential expression of monoamine oxidase A, serotonin transporter, tyrosine hydroxylase and norepinephrine transporter mRNA by anorexia mutation and food deprivation. Dev Brain Res 1998; 107:241-6
15. Johansen JE, Broberger C, Lavebratt C, Johansson C, Kuhar MJ, Hokfelt T, Schalling M. Hypothalamic CART and serum leptin levels are reduced in the anorectic (anx/anx) mouse. Mol Brain Res 2000;84:97-105
16. Klinkenberg M, Willems DL, Wal G, Deeg DJ. Symptom burden in the last week of life. J Pain Symptom Manage 2004;27:5-13
17. Linnet K, Koed K, Wiborg O, Gregersen N. Serotonin depletion decreases serotonin transporter mRNA levels in rat brain. Brain Res 1995;697;251-3
18. Lira A, Zhou M, Castanon N, Ansorge MS, Gordon JA, Francis JH, Bradley-Moore M, Lira J, Underwood MD, Arango V, Kung HF, Hofer MA, Hen R, Gingrich JA. Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biol Psychiatry 2003;54:960-71
19. Maes M, Meltzer HYM. The serotonin hypothesis of major depression. In Psychopharmacology: The Fourth Generation of Progress. (Bloom F, Kupher D, eds), 1995, 933-944, Raven Press, New York, NY
20. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1:1155-61
21. Mann JJ. Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology 1999;21:S99-S105
22. McCarthy DO, Daun JM. The effects of cyclooxygenase inhibits on tumor-induced anorexia in rats. Cancer 1993;71: 486-92
23. Paxinos G, Watson C. The rat brain in stereotaxic coordinate. 1986, Academic Press
24. Yamada J, Sugimoto Y, Hirose H, Kajiwara Y. Role of serotonergic mechanisms in leptin-induced suppression of milk intake in mice. Neurosci Lett 2003;348:195-7