Effect of 2 weeks of endurance training on uncoupling protein 3 content in untrained human subjects

Acta Physiologica Scandinavica

Volumn 183, Issue 3, 2005, Pages 273-280

  Schrauwen, P ^a   Russell, A P ^b   Moonen Kornips, E ^a   Boon, N ^a   Hesselink, M K C ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b SUVA   (Switzerland)

Author keywords

Exercise; Mitochondria; Training; Uncoupling protein

Indexed keywords

CYTOCHROME C; UNCOUPLING PROTEIN 3;

ARTICLE; ATHLETE; BODY MASS; CONTROLLED STUDY; ENDURANCE; ENERGY YIELD; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MUSCLE BIOPSY; MUSCLE STRENGTH; NORMAL HUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTON TRANSPORT; THERMOGENESIS; TRAINING;

ADULT; ANTHROPOMETRY; CARRIER PROTEINS; CYTOCHROMES C; ENERGY METABOLISM; EXERCISE; HUMANS; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; PHYSICAL ENDURANCE;

EID: 15244361442     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-201X.2004.01393.x     Document Type: Article

References (31)

1. Bergstrom, J., Hermansen, L., Hultman, E. St Saltin, B. 1967. Diet, muscle glycogen and physical performance. Acta Physiol Scand 71, 140-150.
2. Boss, O., Samec, S., Paoloni-Giacobino, A. et al. 1997. Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett 408, 39-42.
3. Boss, O., Samec, S., Desplanches, D. et al. 1998. Effect of endurance training on mRNA expression of uncoupling proteins 1, 2 and 3 in the rat. FASEB J 12, 335-339.
4. Cortright, R.N., Zheng, D., Jones, J.P. et al. 1999. Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation. Am J Physiol Endocrinol Metab 276, E217-E221.
5. Fernstrom, M., Tonkonogi, M. St Sahlin, K. 2004. Effects of acute and chronic endurance exercise on mitochondrial uncoupling in human skeletal muscle. J Physiol 554, 755-763.
6. Goglia, F. St Skulachev, V.P. 2003. A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet. FASEB J 17, 1585-1591.
7. Harris, J.A. St Benedict, F.G. 1919. A Biometric Study of Basal Metabolism in Man. Carnegie Institution of Washington, Washington, DC.
8. Hesselink, M.K.C., Greenhaff, P.L., Constantin-Teodosiu, D. et al. 2003. Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo. J Clin Invest 111, 479-486.
9. Himms-Hagen, J. St Harper, M.E. 2001. Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp Biol Med (Maywood) 226, 78-84.
10. Hjeltnes, N., Fernström, M., Zierath, J.R. St Krook, A. 1999. Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects. Diabetologia 42, 826-830.
11. Jones, T.E., Baar, K., Ojuka, E., Chen, M. & Holloszy, J.O. 2003. Exercise induces an increase in muscle UCP3 as a component of the increase in mitochondrial biogenesis. Am J Physiol Endocrinol Metab 284, E96-E101.
12. Khalfallah, Y., Fages, S., Laville, M., Langin, D. & Vidal, H. 2000. Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue. Diabetes 49, 25-31.
13. Kuipers, H., Saris, W.H.M., Brouns, F., Keizer, H.A. & ten Bosch, C. 1989. Glycogen synthesis during exercise and rest with carbohydrate feeding in males and females. Int J Sports Med 10, S63-S67.
14. Nedergaard, J., Golozoubova, V., Matthias, A., Asadi, A., Jacobsson, A. St Cannon, B. 2001. UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochim Biophys Acta 1504, 82-106.
15. Noland, R.C., Hickner, R.C., Jimenez-Linan, M. et al. 2003. Acute endurance exercise increases skeletal muscle uncoupling protein-3 gene expression in untrained but not trained humans. Metabolism 52, 152-158.
16. Pilegaard, H., Ordway, G.A., Saltin, B. & Neufer, P.D. 2000. Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol Endocrinol Metab 279, E806-E814.
17. Pilegaard, H., Keller, C., Steensberg, A. et al. 2002. Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes. J Physiol 541, 261-271.
18. Russell, A., Wadley, G., Snow, R. et al. 2002. Slow component of [V]O(2) kinetics: the effect of training status, fibre type, UCP3 mRNA and citrate synthase activity. Int J Obes Relat Metab Disord 26, 157-164.
19. Russell, A.P., Somm, E., Praz, M. et al. 2003a. UCP3 protein regulation in human skeletal muscle fibre types I, IIa and IIx is dependent on exercise intensity. J Physiol 550, 855-861.
20. Russell, P., Wadley, G., Hesselink, M.K.C. et al. 2003b. UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects. Pflugers Archiv Eur J Physiol 445, 563-569.
21. Schrauwen, P. Sc Hesselink, M. 2002. UCP2 and UCP3 in muscle controlling body metabolism. J., Exp Biol 205, 2275-2285.
22. Schrauwen, P., Troost, F.J., Xia, J., Ravussin, E. & Saris, W.H. 1999. Skeletal muscle UCP2 and UCP3 expression in trained and untrained male subjects. Int J Obes Relat Metab Disord 23, 966-972.
23. Schrauwen, P., Schaart, G., Saris, W.H. et al. 2000. The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects. Diabetologia 43, 1408-1416.
24. Schrauwen, P., Saris, W.H. St Hesselink, M.K. 2001. An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of non-esterified fatty acids inside the mitochondrial matrix. FASEB J 15, 2497-2502.
25. Schrauwen, P., Hesselink, M.K., Vaartjes, I. et al. 2002. Effect of acute exercise on uncoupling protein 3 is a fat metabolism- mediated effect. Am J Physiol Endocrinol Metab 282, E11-E17.
26. Schrauwen-Hinderling, V.B., Schrauwen, P., Hesselink, M.K. et al. 2003. The increase in intramyocellular lipid content is a very early response to training. J Clin Endocrinol Metab 88, 1610-1616.
27. Siri, W.E. 1956. The gross composition of the body. Adv Biol Med Physiol 4, 239-280.
28. Tsuboyama-Kasaoka, N., Tsunoda, N., Maruyama, K. et al. 1998. Up-regulation of uncoupling protein 3 (UCP3) mRNA by exercise training and down-regulation of UCP3 by denervation in skeletal muscles. Biochem Biophys Res Commun 247, 498-503.
29. Tunstall, R.J., Mehan, K.A., Hargreaves, M., Spriet, L.L. & Cameron-Smith, D. 2002. Fasting activates the gene expression of UCP3 independent of genes necessary for lipid transport and oxidation in skeletal muscle. Biochem Biophys Res Commun 294, 301-308.
30. Weir, J.B. 1949. New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 109, 1-9.
31. Zhou, M., Lin, B.Z., Coughlin, S., Vallega, G. & Pilch, P.F. 2000. UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase. Am J Physiol Endocrinol Metab 279, E622-E629.