Nasal absorption and pharmacokinetic disposition of salmon calcitonin modified with low molecular weight polyethylene glycol

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 8, 2004, Pages 957-960

  Shin, Beom Soo ^a   Jung, Ji Hoon ^a   Lee, Kang Choon ^a   Yoo, Sun Dong ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

Nasal absorption; PEGylation; Pharmacokinetics; Salmon calcitonin (sCT)

Indexed keywords

IODINE; IODINE 125; MACROGOL 2000; SALCATONIN; SUCCINIMIDYL PROPIONATED MONOMETHOXYPOLY(ETHYLENE GLYCOL); UNCLASSIFIED DRUG; CALCITONIN; MACROGOL DERIVATIVE; PEPTIDE HYDROLASE; RADIOACTIVE IODINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG STABILITY; DRUG TRANSPORT; GEL PERMEATION CHROMATOGRAPHY; HYPOTHESIS; ISOMER; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEMBRANE TRANSPORT; MOLECULAR WEIGHT; NONHUMAN; NOSE MUCOSA; PROTEIN DEGRADATION; RADIOACTIVITY; RADIOIODINATION; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TISSUE; URINALYSIS; ABSORPTION; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; GEL CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERISM; MASS SPECTROMETRY; METABOLISM; NOSE;

ABSORPTION; ANIMALS; CALCITONIN; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; IODINE RADIOISOTOPES; ISOMERISM; MOLECULAR WEIGHT; NOSE; PEPTIDE HYDROLASES; POLYETHYLENE GLYCOLS; RATS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 15244353166     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.957     Document Type: Article

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