In vivo evaluation of tablets and capsules containing spray-dried o/w-emulsions for oral delivery of poorly soluble drugs

International Journal of Pharmaceutics

Volumn 293, Issue 1-2, 2005, Pages 203-211

  Hansen, Tue ^a,b   Holm, Per ^c   Rohde, Morten ^a   Schultz, Kirsten ^a  

^a H LUNDBECK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c LifeCycle Pharma   (Denmark)

Author keywords

Beagle dogs; Dry emulsion; Lipid solution; Medium chain triglycerides; Oral absorption; Poorly soluble drug

Indexed keywords

1' [4 [1 (4 FLUOROPHENYL) 1H INDOL 3 YL] 1 BUTYL]SPIRO(ISOBENZOFURAN 1(3H),4' PIPERIDINE); 2 HYDROXYPROPYL BETA CYCLODEXTRIN; ATTAPULGITE; FAT DROPLET; GELATIN; HYDROXYPROPYLMETHYLCELLULOSE; LU 28 179; MEDIUM CHAIN TRIACYLGLYCEROL; METHYLCELLULOSE; NEUSILIN; PIPERIDINE DERIVATIVE; TREHALOSE; UNCLASSIFIED DRUG; WATER OIL CREAM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG SOLUBILITY; DRY POWDER; ENCAPSULATION; FEMALE; NONHUMAN; PRIORITY JOURNAL; SPRAY DRYING; STATISTICAL SIGNIFICANCE; TABLET COMPRESSION; TABLET FORMULATION;

EID: 15244348769     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.01.003     Document Type: Article

References (17)

1. P.J. Carrigan, and T.R. Bates Biopharmaceutics of drugs administered in lipid-containing dosage forms. I. GI absorption of griseofulvin from an oil-in-water emulsion in the rat J. Pharm. Sci. 62 1973 1476 1479
2. S. Chakrabarti, and F.M. Belpaire Bioavailability of phenytoin in lipid containing dosage forms in rats J. Pharm. Pharmacol. 30 1978 330 331
3. W.N. Charman Lipids, lipophilic drugs, and oral drug delivery - some emerging concepts J. Pharm. Sci. 89 2000 967 978
4. W.N. Charman, C.J.H. Porter, S. Mithani, and J.B. Dressman Physicochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH J. Pharm. Sci. 86 1997 269 282
5. Christensen, J.Ø., 2004. Evaluation of an in vitro lipid digestion model - testing poorly soluble drug substances and lipid-based formulations. Ph.D. Thesis, The Danish University of Pharmaceutical Sciences, Denmark.
6. K.L. Christensen, G.P. Pedersen, and H.G. Kristensen Preparation of redispersible dry emulsions by spray drying Int. J. Pharm. 212 2001 187 194
7. K.L. Christensen, G.P. Pedersen, and H.G. Kristensen Technical optimisation of redispersible dry emulsions Int. J. Pharm. 212 2001 195 202
8. P.C. De Smidt, M.A. Campanero, and I.F. Trocóniz Intestinal absorption of penclomedine from lipid vehicles in the conscious rat: contribution of emulsification versus digestibility Int. J. Pharm. 270 2004 109 118
9. G. Dollo, P. Le Corre, A. Guérin, F. Chevanne, J.L. Burgot, and R. Leverge Spray-dried redispersible oil-in-water emulsion to improve oral bioavailability of poorly soluble drugs Eur. J. Pharm. Sci. 19 2003 273 280
10. T. Hansen, P. Holm, and K. Schultz Process characteristics and compaction of spray-dried emulsions containing a drug dissolved in lipid Int. J. Pharm. 287 2004 55 66
11. A.J. Humberstone, and W.N. Charman Lipid-based vehicles for the oral delivery of poorly water soluble drugs Adv. Drug Deliv. Rev. 25 1997 103 128
12. G.P. Pedersen, P. Faldt, B. Bergenstahl, and H.G. Kristensen Solid state characterisation of a dry emulsion: a potential drug delivery system Int. J. Pharm. 171 1998 257 270
13. C.J.H. Porter, S.A. Charman, R.D. Williams, M.V. Bakalova, and W.N. Charman Evaluation of emulsifiable glasses for the oral administration of cyclosporin in beagle dogs Int. J. Pharm. 141 1996 227 237
14. C.W. Pouton Lipid formulations for oral administration of drugs: non-emulsifying, self emulsifying and self microemulsifying drug delivery systems Eur. J. Pharm. Sci. 11 2000 S93 S98
15. H. Takeuchi, H. Sasaki, T. Niwa, T. Hino, Y. Kawashima, K. Uesugi, and H. Ozawa Redispersible dry emulsion system as novel oral dosage form of oily drugs: in vivo studies in beagle dogs Chem. Pharm. Bull. 39 1991 3362 3364
16. H. Takeuchi, H. Sasaki, T. Niwa, T. Hino, Y. Kawashima, K. Uesugi, and H. Ozawa Design of redispersible dry emulsion as an advanced dosage form of oily drug (Vitamin E nicotinate) by spray-drying technique Drug Dev. Ind. Pharm. 18 1992 919 937
17. B.D. Tarr, and S.H. Yalkowsky Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size Pharm. Res. 6 1989 40 43