Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 288, Issue 4 51-4, 2005, Pages

  Sellers, Zachary M ^a   Childs, Debbie ^a   Chow, Jimmy Y C ^a   Smith, Anders J ^a   Hogan, Daniel L ^a,b   Isenberg, Jon I ^a   Dong, Hui ^a   Barrett, Kim E ^a   Pratha, Vijaya S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Univ of CA S Diego Medical Center ^*  (United States)

Author keywords

Chloride bicarbonate exchange; Cystic fibrosis; Tyrosine kinase

Indexed keywords

8 BROMO CYCLIC GMP; BICARBONATE; CHLORIDE; ESCHERICHIA COLI ENTEROTOXIN; FORSKOLIN; GENISTEIN; HERBIMYCIN A; PROTEIN TYROSINE KINASE; UROGUANYLIN;

ANALYSIS OF VARIANCE; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DUODENUM MUCOSA; DUODENUM SECRETION; ENZYME ACTIVITY; GENOTYPE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PERFUSION; PH; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; THERMOSTABILITY; VOLTAGE CLAMP;

ANIMALS; BACTERIAL TOXINS; BENZOQUINONES; BICARBONATES; CELL MEMBRANE; CHLORIDE-BICARBONATE ANTIPORTERS; CYCLIC GMP; CYSTIC FIBROSIS; DUODENUM; ENTEROTOXINS; ENZYME INHIBITORS; FORSKOLIN; GENISTEIN; LACTAMS, MACROCYCLIC; MICE; NATRIURETIC PEPTIDES; PEPTIDES; PROTEIN-TYROSINE KINASES; QUINONES;

EID: 15244346301     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00386.2004     Document Type: Article

References (46)

1. Allen A, Flemstrom G, Garner A, and Kivilaakso E. Gastroduodenal mucosal protection. Physiol Rev 73: 823-857, 1993.
2. Ameen N, Alexis J, and Salas P. Cellular localization of the cystic fibrosis transmembrane conductance regulator in mouse intestinal tract. Histochem Cell Biol 114: 69-75, 2000.
3. Anderson MP, Berger HA, Rich DP, Gregory RJ, Smith AE, and Welsh MJ. Nucleoside triphosphates are required to open the CFTR chloride channel. Cell 67: 775-784, 1991.
4. Anderson MP, Sheppard DN, Berger HA, and Welsh MJ. Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia. Am J Physiol Lung Cell Mol Physiol 263: L1-L14, 1992.
5. Bear C, Li C, Kartner N, Bridges R, Jensen T, Ramjeesingh M, and Riordan J. Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR). Cell 21: 809-818, 1992.
6. Boat T, Welsh MJ, and Beaudet A. Cystic fibrosis. In: The Metabolic Basis of Inherited Disease, edited by Scriver C, Beaudet A and Sly W. New York: McGraw-Hill, 1989, p. 2649-2680.
7. Carrithers S, Ott C, Hill M, Johnson B, Cai W, Chang J, Shah R, Sun C, Mann E, Fonteles M, Forte LR, Jackson B, Giannella R, and Greenberg R. Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor. Kidney Int 65: 40-53, 2004.
8. Charney A, Egnor R, Alexander-Chacko J, Zaharia V, Mann E, and Giannella R. Effect of E. coli heat-stable enterotoxin on colonic transport in guanylyl cyclasee C receptor-deficient mice. Am J Physiol Gastrointest Liver Physiol 280: G216-G221, 2001.
9. Clarke L, Gawenis L, Franklin C, and Harline M. Increased survival of CFTR knockout mice with an oral osmotic laxative. Lab Anim Sci 46: 612-618, 1996.
10. - secretion across murine duodenum. Am J Physiol Gastrointest Liver Physiol 274: G718-G726, 1998.
11. Crane M, Hugues M, O'Hanley P, and Waldman S. Identification of two affinity states of low affinity receptors for Escherichia coli heat-stable enterotoxin: correlation of occupation of lower affinity state with guanylate cyclase activation. Mol Pharmacol 41: 1073-1080, 1992.
12. Deshmane SP, Carrithers SL, Parkinson SJ, Crupper SS, Robertson DC, and Waldman SA. Rat guanylyl cyclase C expressed in COS-7 cells exhibits multiple affinities for Escherichia coli heat-stable enterotoxin. Biochemistry 34: 9095-9102, 1995.
13. Deshmane SP, Parkinson SJ, Crupper SS, Robertson DC, Schulz S, and Waldman SA. Cytoplasmic domains mediate the ligand-induced affinity shift of guanylyl cyclase C. Biochemistry 36: 12921-12929, 1997.
14. Eggermont E and De Boeck K. Small-intestinal abnormalities in cystic fibrosis patients. Eur J Pediatr 150: 824-828, 1991.
15. - transport: characteristics and proposed role in acidity regulation and mucosal protection. Am J Physiol Gastrointest Liver Physiol 242: G183-G193, 1982.
16. Flemstrom G and Isenberg JI. Gastroduodenal mucosal alkaline secretion and mucosal protection. News Physiol Sci 16: 23-28, 2001.
17. Furukawa O, Hirokawa M, Guth P, Engel E, and Kaunitz J. Role of protein kinases on acid-induced duodenal bicarbonate secretion in rats. Pharmacology 67: 99-105, 2003.
18. Gadsby D and Nairn A. Regulation of CFTR channel gating. Trends Biochem Sci 19: 513-518, 1994.
19. Gilljam M, Chaparro C, Tullis E, Chan C, Keshavjee S, and Hutcheon M. GI complications after lung transplantation in patients with cystic fibrosis. Chest 123: 37-41, 2003.
20. - secretion is absent in cystic fibrosis. Gastroenterology 107: 950-956, 1994.
21. Gross R. Escherichia coli diarrhea. J Infect 7: 177-192, 1983.
22. - secretion: proposed mechanism and comparison with other secretagogues. Gastroenterology 111: 1558-1568, 1996.
23. Hakki S, Robertson D, and Waldman S. A 56 kDa binding protein for Escherichia coli heat-stable enterotoxin isolated from the cytoskeleton of rat intestinal membranes does not possess guanylate cyclase activity. Biochim Biophys Acta 1152: 1-8, 1993.
24. - secretion. Am J Physiol Gastrointest Liver Physiol 272: G872-G878, 1997.
25. Hogan DL, Crombie DL, Isenberg JI, Svendsen P, Schaffalitzky de Muckadell OB, and Ainsworth MA. Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice. Gastroenterology 113: 533-541, 1997.
26. Hugues M, Crane M, Hakki S, O'Hanley P, and Waldman S. Identification and characterization of a new family of high-affinity receptors for Escherichia coli heat-stable enterotoxin in rat intestinal membranes. Biochemistry 30: 10738-10745, 1991.
27. Isenberg JI, Selling J, Hogan DL, and Koss MA. Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med 12: 374-379, 1987.
28. Ivens K, Gazzano H, O'Hanley P, and Waldman S. Heterogeneity of intestinal receptors for Escherichia coli heat-stable enterotoxin. Infect Immun 58: 1817-1820, 1990.
29. Jaleel M, Shenoy AR, and Visweswariah SS. Tyrphostins are inhibitors of guanylyl and adenylyl cyclases. Biochemistry 43: 8247-8255, 2004.
30. - secretion by uroguanylin. Am J Physiol Gastrointest Liver Physiol 274: G633-G644, 1998.
31. Kartner N, Hanrahan J, Jensen T, Naismith A, Sun S, Ackerley C, Reyes E, Tsui L, Rommens J, and Bear C. Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance. Cell 22: 681-691, 1991.
32. - transport in cystic fibrosis. EMBO J 21: 5662-5672, 2002.
33. Mann E, Cohen M, and Giannella R. Comparison of receptors for Escherichia coli heat stable enterotoxin: novel receptor present in IEC-6 cells. Am J Physiol Gastrointest Liver Physiol 264: G172-G178, 1993.
34. Mann E, Jump M, Wu J, Yee E, and Giannella R. Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion. Biochem Biophys Res Commun 239: 463-466, 1997.
35. Poulsen JH, Fischer H, Illek B, and Machen TE. Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci USA 91: 5340-5344, 1994.
36. Pratha V, Hogan DL, Martensson B, Bernard J, Zhou R, and Isenberg JI. Identification of transport abnormalities in duodenal mucosa and duodenal enterocytes from patients with cystic fibrosis. Gastroenterology 118: 1051-1060, 2000.
37. Puceat M, Roche S, and Vassort G. Src family tyrosine kinase regulates intracellular pH in cardiomyocytes. J Cell Biol 141: 1637-1646, 1998.
38. Rao S, Sellers Z, Crombie DL, Hogan DL, Mann E, Childs D, Keely S, Sheil-Puopolo M, Giannella R, Barrett K, Isenberg JI, and Pratha V. A role for guanylate cyclase C in acid-stimulated duodenal mucosal bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 286: G95-G101, 2004.
39. Reddy M and Quinton PM. Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells. Nature 423: 756-760, 2003.
40. - cotransport activity in renal epithelial cells. Am J Physiol Renal Physiol 280: F844-F850, 2001.
41. Robinson PJ, Smith AL, and Sly PD. Duodenal pH in cystic fibrosis and its relationship to fat malabsorption. Dig Dis Sci 35: 1299-1304, 1990.
42. - secretion. J Physiol 505: 411-423, 1997.
43. Snouwaert J, Brigman K, Latour A, Malouf N, Boucher R, Smithies O, and Koller B. An animal model for cystic fibrosis made by gene targeting. Science 257: 1083-1088, 1992.
44. Tuo B and Isenberg JI. Effect of 5-hydroxytryptamine on duodenal mucosal bicarbonate secretion in mice. Gastroenterology 125: 805-814, 2003.
45. Vaandrager A. Structure and function of the heat-stable enterotoxin receptor/guanylyl cyclase C. Mol Cell Biochem 230: 73-83, 2002.
46. Youngberg CA, Berardi RR, Howatt WF, Hyneck ML, Amidon GL, Meyer JH, and Dressman JB. Comparison of gastrointestinal pH in cystic fibrosis and healthy subjects. Dig Dis Sci 32: 472-480, 1987.