Conformationally constrained analogues of the muscarinic agonist 3-(4- (methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine. Synthesis, receptor affinity, and antinociceptive activity

Journal of Medicinal Chemistry

Volumn 41, Issue 1, 1998, Pages 109-116

  Sauerberg, Per ^a   Olesen, Preben H ^a   Sheardown, Malcolm J ^a   Rimvall, Karin ^a   Thøgersen, Henning ^a   Shannon, Harlan E ^b   Sawyer, Barry D ^b   Ward, John S ^b   Bymaster, Frank P ^b   DeLapp, Neil W ^b   Calligaro, David O ^b   Swedberg, Michael D B ^a  

^a NOVO NORDISK A S   (Denmark)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [4 (METHYLTHIO) 1,2,5 THIADIAZOL 3 YL] 1,2,5,6 TETRAHYDRO 1 METHYLPYRIDINE; 3 [4 (METHYLTHIO) 1,2,5 THIADIAZOL 3 YL] 1,2,5,6 TETRAHYDRO 1 METHYLPYRIDINE DERIVATIVE; 3 [4 (METHYLTHIO) 1,2,5 THIADIAZOL 3 YL] 1,2,5,6 TETRAHYDROPYRIDINE; 5,6,7,8 TETRAHYDRO[1,2,5]THIADIAZOLO[3',4':4,5]THIENO[3,2 C]PYRIDINE OXALATE; 8 METHYL 6,7,8,9 TETRAHYDRO[1,2,5]THIADIAZOLO[3',4':2,3]THIOPYRANO[4,5 C]PYRIDINE OXALATE; MUSCARINIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CHO CELL; CHOLINERGIC ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYPERSALIVATION; MALE; MOUSE; NONHUMAN; RECEPTOR AFFINITY; TREMOR;

EID: 15144339106     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9705216     Document Type: Article

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