3-(3-Alkylthio-1,2,5-thiadiazol-4-yl)-1-azabicycles. Structure-activity relationships for antinociception mediated by central muscarinic receptors

European Journal of Medicinal Chemistry

Volumn 31, Issue 3, 1996, Pages 221-230

  Olesen, P H ^a   Sauerberg, P ^a   Treppendahl, S ^a   Larsson, O ^a   Sheardown, M J ^a   Suzdak, P D ^a   Mitch, C H ^b   Ward, J S ^b   Bymaster, F P ^b   Shannon, H E ^b   Swedberg, M D B ^a  

^a NOVO NORDISK A S   (Denmark)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Antinociception; Muscarinic receptor; Structure activity relationship; Thiadiazol 1 azabicycle

Indexed keywords

1,2,5 THIADIAZOLE DERIVATIVE; 3 (3 BUTYLTHIO 1,2,5 THIADIAZOL 4 YL 1 AZABICYLO[2.2.2]OCTANE]; ANTINOCICEPTIVE AGENT; MORPHINE; MUSCARINIC RECEPTOR; NORBORNANE DERIVATIVE; OXOTREMORINE; QUINUCLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; MOUSE; NONHUMAN; REACTION ANALYSIS; RECEPTOR AFFINITY; SALIVATION; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION; TREMOR;

EID: 0029670102     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/0223-5234(96)89138-0     Document Type: Article

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