Ondansetron: A selective 5-HT3 receptor antagonist and its applications in CNS-related disorders

CNS Drug Reviews

Volumn 7, Issue 2, 2001, Pages 199-213

  Ye, Jiang Hong ^a   Ponnudurai, Rex ^a   Schaefer, Rebecca ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

5 Hydroxytryptamine3 antagonist; Alcoholism; Antiemetics; Ondansetron; Serotonin receptors

Indexed keywords

ANESTHETIC AGENT; ANTIEMETIC AGENT; ANTIHISTAMINIC AGENT; ANTINEOPLASTIC AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CISPLATIN; DEXAMETHASONE; DOLASETRON MESILATE; DOPAMINE RECEPTOR BLOCKING AGENT; DROPERIDOL; FENTANYL; GRANISETRON; ONDANSETRON; SEROTONIN; SEROTONIN 3 ANTAGONIST; TROPISETRON;

ALCOHOLISM; ANXIETY NEUROSIS; CENTRAL NERVOUS SYSTEM; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; COCAINE DEPENDENCE; DRUG COST; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; DRUG SAFETY; DRUG SELECTIVITY; GASTROINTESTINAL DISEASE; GILLES DE LA TOURETTE SYNDROME; HEADACHE; HUMAN; META ANALYSIS; NONHUMAN; POSTOPERATIVE VOMITING; PROPHYLAXIS; PRURITUS; RADIATION INDUCED EMESIS; REVIEW; WITHDRAWAL SYNDROME;

EID: 0034957144     PISSN: 1080563X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3458.2001.tb00195.x     Document Type: Review

References (76)

1. 3-receptor antagonist, can both abolish emesis induced by cyclophosphamide or radiation in the ferret
2. The mechanism of emesis induced by anticancer therapies
3. 3-receptor antagonist BRL24924 in the inhibition of radiation-evoked emesis in the ferret
4. ASHP therapeutic guidelines on the pharmacologic management of nausea and vomiting in adult and pediatric patients receiving chemotherapy or radiation therapy or undergoing surgery
5. Ondansetron therapy for uremic pruritus in hemodialysis patients
6. A review of central 5-HT receptors and their function
7. Ligand-gated ion channels in the brain: The amino acid receptor superfamily
8. 5-HT antagonists attenuate MK801-impaired radial arm maze performance in rats
9. Dolasetron prevents postanesthetic shivering
10. Ondansetron is effective to treat spinal or epidural morphine-induced pruritus
11. Acute myocardial ischemia after administration of ondansetron hydrochloride
12. Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
13. Behavioral, physiological and neuroendocrine responses in healthy volunteers to μ-chlorophenylpiperazine (m-CPP) with and without ondansetron pretreatment
14. The role of 5-HT in postoperative nausea and vomiting
15. 3 receptors
16. Level of punishment determines anticonflict activity of ondansetron in pigeons: Comparison with buspirone and diazepam
17. Ondansetron is more effective than metoclopramide for the treatment of opioid-induced emesis in post-surgical adult patients
18. Nausea and vomiting
19. GR38032F, a novel inhibitor of cisplatin-induced emesis in the ferret
20. 3 receptor antagonists: A review of pharmacology and clinical efficacy
21. Effects of ondansetron pretreatment on acute responses to ethanol in social drinkers
22. A randomized double-blind comparison of ondansetron, droperidol and placebo for prevention of postoperative nausea and vomiting after supratentorial craniotomy
23. 3 antagonism (ondansetron)
24. 3-receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy
25. Serotonin receptor physiology: Relation to emesis
26. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
27. Medications to treat alcoholism
28. Neuropharmacological treatments for alcoholism: Scientific basis and clinical findings
29. Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trial
30. Evolving concepts of the pathogenesis and treatment of the pruritus of cholestasis
31. Risk factors for postoperative nausea and vomiting
32. 3-receptor antagonist
33. 3 receptor antagonist, and cocaine
34. A receptors
35. Prevention and treatment of postoperative nausea and vomiting
36. 3 antagonists?
37. 3 receptors and the neural actions of alcohols: An increasingly exciting topic
38. Intrathecal fentanyl is superior to intravenous ondansetron for the prevention of perioperative nausea during cesarean delivery with spinal anesthesia
39. 3 antagonist ondansetron with high dose metoclopramide in the control of cisplatin-induced emesis
40. Evaluation of the effects of diazepam and an experimental anti-anxiety drug on regional cerebral blood flow
41. Selective 5-hydroxytryptamine antagonism: A role in irritable bowel syndrome and functional dyspepsia?
42. Animal models of alcoholism: Neurobiology of high alcohol-drinking behavior in rodents
43. 3 antagonist, ondansetron, on the behavioral and physiological effects of pentagastrin in patients with panic disorder and social phobia
44. Psychosis: Impact on the patient and family
45. Treatment of pruritus in chronic liver disease with the 5-hydroxytryptamine receptor type 3 antagonist ondansetron: A randomized, placebo-controlled, double-blind cross-over trial
46. Renal itch
47. The physiology and pharmacology of postoperative nausea and vomiting
48. Serotonin (5-hydroxytryptamine)
49. 3 regimen and literature review
50. Effects of ondansetron administration on opioid withdrawal syndrome observed in rats
51. Pharmacology of neuromuscular blocking drugs
52. Results of a randomized, double-blind comparative study of ondansetron and metoclopramide in the prevention of nausea and vomiting following high-dose upper abdominal irradiation
53. Comparison of ondansetron with ondansetron and dexamethasone in prevention of PONV in diagnostic laparoscopy
54. Pharmacological evaluation of a modified open-field test sensitive to anxiolytic drugs
55. Disorders of vasodilator hormones: The carcinoid syndrome and mastocytosis
56. 3-receptor antagonists: Differences and similarities
57. 3 antagonist, in benzodiazepine discontinuation
58. 3 antagonist, in a novel animal model
59. 3 antagonists in postoperative nausea and vomiting
60. The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test
61. Use of the selective serotonin 3 receptor antagonist ondansetron in the treatment of neuroleptic-induced tardive dyskinesia
62. A comparison of the prophylactic antiemetic effect of ondansetron and droperidol on patients undergoing gynecologic laparoscopy
63. 3-receptor antagonist, GR38032F
64. Intravenous ondansetron for the control of opioid-induced nausea and vomiting
65. Ondansetron treatment in patients with Tourette's syndrome
66. A quantitative systematic review of ondansetron in treatment of established postoperative nausea and vomiting
67. Cost-effectiveness of ondansetron for postoperative nausea and vomiting
68. 3 receptor research
69. The cost-effective management of postoperative nausea and vomiting
70. Ondansetron. A review of its pharmacology and preliminary clinical findings in novel applications
71. A current of rat central nervous system neurons
72. Ondansetron exhibits the properties of a local anesthetic
73. Inhibitory effect of ondansetron on glycine response of dissociated rat hippocampal neurons
74. Prophylactic intravenous ondansetron reduces the incidence of intrathecal morphine-induced pruritus in patients undergoing cesarean delivery
75. Zofran (ondansetron hydrochloride) and clinical pharmacology
76. Zofran (ondansetron hydrochloride) and dosage adjustment in patients with hepatic dysfunction