Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia

Atherosclerosis

Volumn 179, Issue 2, 2005, Pages 333-338

  Pisciotta, Livia ^a   Cortese, Claudio ^b   Gnasso, Agostino ^c   Liberatoscioli, Laura ^b   Pastore, Anna ^d   Mannucci, Liliana ^b   Irace, Concetta ^c   Federici, Giorgio ^b,d   Bertolini, Stefano ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

Coronary artery disease; Familial hypercholesterolemia; Homocysteine; Methylenetetrahydrofolate reductase; Myocardial infarction

Indexed keywords

HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADULT; ANGIOGRAPHY; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HEART INFARCTION; HETEROZYGOSITY; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; SEX RATIO;

EID: 14944385144     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2004.10.016     Document Type: Article

References (26)

1. R. Clarke, L. Daly, and K. Robinson Hyperhomocysteinemia: an independent risk factor for vascular disease N Engl J Med 324 1991 1149 1155
2. C.J. Boushey, Beresford SAA, G.S. Omenn, and A.G. Motulsky A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes JAMA 274 1995 1049 1057
3. A.G. Motulsky Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid Am J Hum Genet 58 1996 17 20
4. S.H. Mudd, H.L. Levy, and F. Skovby Disorders of transsulfuration C.R. Scriver A.L. Beaudet W.S. Sly D. Valle The metabolic basis of inherited disease 7th ed. 1995 McGraw-Hill New York, NY 1279 1326
5. P. Frosst, H.J. Blom, and R. Milos A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nat Genet 10 1995 111 113
6. L. Brattström, D.E.L. Wilcken, J. Öhrvik, and L. Brudin Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease. The results of a meta-analysis Circulation 98 1998 2520 2526
7. M. Kawashiri, K. Kajinami, and A. Nohara Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia Am J Cardiol 86 8 2000 840 845
8. M. Klerk, P. Verhoef, R. Clarke, H.J. Blom, F.J. Kok, and E.G. Schouten MTHFR studies collaboration group. MTHFR 677C → T polymorphism and risk of coronary heart disease: a meta-analysis JAMA 288 2002 2023 2031
9. J.L. Goldstein, H.H. Hobbs, and M.S. Brown Familial hypercholesterolemia C.R. Scriver A.L. Beaudet W.S. Sly D. Valle The metabolic and molecular bases of inherited disease 7th ed. 1995 McGraw-Hill New York, NY 1981 2030
10. J.S. Hill, M.R. Hayden, J. Frohlich, and P.H. Pritchard Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia Arterioscler Thromb 11 1991 290 297
11. D.W. Cockcroft, and M.H. Gault Prediction of creatinine clearance from serum creatinine Nephron 16 1976 31 41
12. A. Pastore, R. Massoud, and C. Motti Fully automated assay for total homocysteine, cysteine, cysteinylglycine, glutathione, cysteamine, and 2-mercaptopropionylglycine in plasma and urine Clin Chem 44 1998 825 832
13. C. Motti, A. Gnasso, and S. Bernardini Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine and other risk factors for vascular disease Atherosclerosis 139 1998 377 383
14. D. Girelli, S. Friso, and E. Trabetti Methylenetetrahydrofolate reductase C677T mutation plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental interaction Blood 91 1998 4158 4163
15. D.W. Jacobsen Homocysteine and vitamins in cardiovascular disease Clin Chem 44 1998 1833 1843
16. C.J. Glueck, P. Shaw, and J.E. Lang Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients Am J Cardiol 75 1995 132 136
17. P. Nicholls, I.S. Young, and C.A. Graham Genotype/phenotype correlations in familial hypercholesterolemia Curr Opin Lipidol 9 1998 313 317
18. K.S. McCully Homocysteine and vascular disease Nat Med 2 1996 386 389
19. A.J. Olszewski, and K.S. McCully Homocysteine content of lipoproteins in hypercholesterolemia Atherosclerosis 88 1991 61 68
20. S. Tonstad, H. Refsum, and P.M. Ueland Association between plasma total homocysteine and parental history of cardiovascular disease in children with familial hypercholesterolemia Circulation 96 1997 1803 1808
21. O. Nygård, S.E. Vollset, and H. Refsum Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study JAMA 274 1995 1526 1533
22. S. Tonstad, O. Joakimsen, and E. Stensland-Bugge Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects Arterioscler Thromb Vasc Biol 16 1996 984 991
23. B.J. Verhoeff, M.D. Trip, M.H. Prins, J.J.P. Kastelein, and P.H. Reitsma The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis Atherosclerosis 141 1998 161 166
24. M.C. Verhaar, R.M. Wever, and J.J. Kastelein 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia Circulation 97 1998 237 241
25. J.P. O'Malley, C.L. Maslen, and D.R. Illingworth Angiotensin-converting enzyme DD genotype and cardiovascular disease in heterozygous familial hypercholesterolemia Circulation 97 1998 1780 1783
26. M. Seed, F. Hoppichler, D. Reaveley, S. McCarthy, and G.R. Thompson Relation of serum lipoprotein(a) concentration and apolipoprotein(a) phenotype to coronary heart disease in familial hypercholesterolemia N Engl J Med 322 1990 1494 1499