The role of endogenous hormones in the etiology and prevention of breast cancer: The epidemiological evidence

Annals of the New York Academy of Sciences

Volumn 1028, Issue , 2004, Pages 273-282

  Muti, Paola ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Breast cancer; Epidemiology; Glucose metabolism; Insulin like growth factor

Indexed keywords

ANDROGEN; BRCA1 PROTEIN; BRCA2 PROTEIN; ESTROGEN; SOMATOMEDIN;

BREAST CANCER; CANCER RISK; CONFERENCE PAPER; FAMILY HISTORY; GLUCOSE METABOLISM; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; IONIZING RADIATION; POSTMENOPAUSE; SOCIOECONOMICS;

EID: 14944373265     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1322.031     Document Type: Conference Paper

References (75)

1. INTERNATIONAL AGENCY FOR RESEARCH ON CANCER. 1987. Overall evaluations of carcinogenicity: an updating of IARC monograph volumes 1 to 24. IARC Monogr. Eval. Carcinog. Risks Hum. Suppl. 7: 272-310. Lyon, France.
2. LANDIS, S.H., T. MURRAY, S. BOLDEN, et al. 1999. Cancer statistics, 1999. CA Cancer J. Clin. 49:8-31.
3. METTLIN, C. 1999. Global breast cancer mortality statistics, 1999. CA Cancer J. Clin. 49: 138-144.
4. BERNSTEIN, L. & D. ROSS. 1993. Endogenous hormones and breast cancer risk. In Epidemiologic Reviews - Breast Cancer. J.L. Kelsey, Ed.: 48-65. John Hopkins University School of Hygiene and Public Health. Baltimore, MD.
5. RUSSO, J., Y.F. HU, X. YANG & I.H. RUSSO. 2000. Developmental, cellular, and molecular basis of human breast cancer. J. Natl. Cancer Inst. Monogr. 27: 17-37.
6. SECRETO, G., C. RECCHIONE, G. FARISELLI & S. DI PIETRO. 1984. High testosterone and low progesterone circulating levels in premenopausal patients with hyperplasia and cancer of the breast. Cancer Res. 44: 841-844.
7. SECRETO, G., P. TONIOLO, P. PISANI, et al. 1989. Androgens and breast cancer in premenopausal women. Cancer Res. 49: 471-476.
8. BEATSON, G.T. 1896. On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment with illustrative cases. Lancet 2: 104-207.
9. LACASSAGNE, A. 1932. Apparition de cancers de la mammelle chez la souris male, soumise à des injections de folliculine. C.R. Acad. Sci. 195: 630-632.
10. INTERNATIONAL AGENCY FOR RESEARCH ON CANCER. 1997. IARC Cancer Incidence in Five Continents, Vol. VII. D.M. Parlin, J. Whelan, L. Ferlay, et al., Eds. IARC Scientific Publications.
11. CAVALIERI, E., K. FRENKEL, J.G. LIEHR & R.D. ROGAN. 2000. Estrogens as endogenous genotoxic agents - DNA adducts and mutation. J. Natl. Cancer Inst. Monogr. 27: 75-94.
12. FLÖLOTTO, T., S. DJAHANSOUZI, M. GLÄSER, et al. 2001. Hormones and hormones antagonists: mechanism of action in carcinogenesis of endometrial and breast cancer. Horm. Metab. Res. 33: 451-457.
13. DORGAN, J.F., C. LONGCOPE, H.E. STEPHENSON, JR., et al. 1996. Relation of prediagnostic serum estrogen and androgen levels to breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 5: 533-539.
14. DORGAN, J.F., F.Z. STANCZYK, C. LONGCOPE, et al. 1997. Relationship of serum dehydroepiandrosterone (DHEA), DHEA sulfate, and 5-androstene-3β, 17β-diol to risk of breast cancer in postmenopausal women. Cancer Epidemiol. Biomarkers Prev. 6: 177-181.
15. THOMAS, H.V., T.J. KEY, D.S. ALLEN, et al. 1997. A prospective study of endogenous serum hormone concentrations and breast cancer risk in postmenopausal women on the island of Guernsey. Br. J. Cancer 76: 401-405.
16. HANKINSON, S.E., W.C. WILLETT, J.E. MANSON, et al. 1998. Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women. J. Natl. Cancer Inst. 90: 1292-1299.
17. TONIOLO, P.G., M. LEVITZ, A. ZELENIUCH-JACQUOTTE, et al. 1995. A prospective study of endogenous estrogens and breast cancer in postmenopausal women. J. Natl. Cancer Inst. 87: 190-197.
18. ZELENIUCH-JACQUOTTE, A., P.F. BRUNING, J.M.G. BONFRER, et al. 1997. Relation of serum levels of testosterone and dehydroepiandrosterone sulfate to risk of breast cancer in postmenopausal women. Am. J. Epidemiol. 145: 1030-1038.
19. BERRINO, F., P. MUTI, A. MICHELI, et al. 1996. Serum sex hormone levels after menopause and subsequent breast cancer. J. Natl. Cancer Inst. 88: 291-296.
20. BARRETT-CONNOR, E., N.J. FRIEDLANDER & K-T. KHAW. 1990. Dehydroepiandrosterone sulfate and breast cancer risk. Cancer Res. 50: 6571-6574.
21. GARLAND, C.F., N.J. FRIEDLANDER, E. BARRETT-CONNOR & K-T. KHAW. 1992. Sex hormones and postmenopausal breast cancer: a prospective study in an adult community. Am. J. Epidemiol. 135: 1220-1230.
22. KABUTO, M, S. AKIBA, R.G. STEVENS, et al. 2000. A prospective study of estradiol and breast cancer in Japanese women. Cancer Epidemiol. Biomarkers Prev. 9: 575-579.
23. CAULEY, J.A., F.L. LUCAS, L.H. KULLER, et al. (for the Study of Osteoporotic Fractures Research Group) 1999. Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer. Ann. Intern. Med. 130: 270-277.
24. GORDON, G.B., T.L. BUSH, K.J. HELZLSOUER, et al. 1990. Relationship of serum levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate to the risk of developing postmenopausal breast cancer. Cancer Res. 50: 3859-3862.
25. HELZLSOUER, K.J., A.J. ALBERG, T.L. BUSH, et al. 1994. A prospective study of endogenous hormones and breast cancer. Cancer Detect. Prev. 18: 79-85.
26. ENDOGENOUS HORMONES AND BREAST CANCER COLLABORATIVE GROUP. Breast cancer and endogenous sex hormones in postmenopausal women: a collaborative re-analysis of data on 650 cases and 1700 controls from nine prospective studies. J. Natl. Cancer Inst. Manuscript in preparation.
27. JAMES, V.H., J.M. MCNEILL, L.C., LAI, et al. 1987. Aromatase activity in normal breast and breast tumor tissues: in vivo and in vitro studies. Steroids 50: 269-279.
28. BERRINO, F. & P. MUTI. 1988. Overview of the etiological hypotheses linking endogenous steroid hormones and breast cancer. In Diet, Hormones and Cancer: Methodological issues for prospective studies. E. Riboli & R. Saracci, Eds. IARC Technical Report No. 4. IARC Scientific Publications.
29. WYSOWSKI, D.K., G.W. COMSTOCK, K.J. HELSING & H.L. LAU. 1987. Sex hormone levels in serum in relation to the development of breast cancer. Am. J. Epidemiol. 125: 791-799.
30. ROSEMBERG, C.R., B.S. PASTERNAK, R.E. SHORE, et al. 1994. Premenopausal estradiol levels and the risks of breast cancer: a new method of controlling for day of the menstrual cycle. Am. J. Epidemiol. 140: 518-525.
31. KEY, T.J.A., D.Y. WANG, J.B. BROWN, et al. 1996. A prospective study of urinary oestrogen excretion and breast cancer risk. Br. J. Cancer 73: 1615-1619.
32. THOMAS, H.V., T.J. KEY, J.W. MOORE, et al. 1997. A prospective study of endogenous serum hormone concentrations and breast cancer risk in premenopausal women on the island of Guernsey. Br. J. Cancer 75: 1075-1079.
33. KELSEY, J.L., M.D. GAMMON & E.M JOHN. 1993. Reproductive factors and breast cancer. Epidemiol. Rev. 15: 36-47.
34. CATT, K.J. & M.L. DUFAU. 1991. Gonadotropic hormones: biosynthesis secretion, receptors, and action. In Reproductive Endocrinology. S.S. Yes & R.B. Jaffe, Eds.: 105-155. Saunders. Philadelphia.
35. MILAZZO, G., F. GIORGINO, F. DAMANTE, et al. 1992. Insulin receptor expression and function in human breast cancer cell lines. Cancer Res. 52: 3924-3930.
36. CULLEN, K.J., D. YEE, W.S. SLY, et al. 1990. Insulin like growth factor receptor expression and function in human breast cancer. Cancer Res. 50: 48-53.
37. OSBORNE, C.K., D.R. CLEMMONS & C.I. ARTEAGA. 1990. Regulation of breast cancer growth by insulin-like growth factors. J. Steroid Biochem. Mol. Biol. 37: 805-809.
38. CARA, J.F. 1994. Insulin-like growth factors, insulin-like growth factor binding proteins and ovarian androgen production. Horm. Res. 42: 49-54.
39. BARBIERI, R.L., A. MAKRIS & K.J. RYAN. 1984. Insulin stimulates androgen accumulation in incubations of human ovarian stroma and theca. Obstet. Gynecol. 64: 73S-80S.
40. NESTLER, J.E. & D.J. JAKUBOWICZ. 1996. Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome [see comments]. N. Engl. J. Med. 335: 617-623.
41. LEWITT, M.S. 1994. Role of the insulin-like growth factors in the endocrine control of glucose homeostasis. Diabetes Res. Clin. Pract. 23: 3-15.
42. JONES, J.I. & D.R. CLEMMONS. 1995. Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 16: 3-34.
43. RINDERKNECHT, E. & R.E. HUMBEL. 1978. Primary structure of human insulin-like growth factor II. FEBS Lett. 89: 283-286.
44. SALTER, J. & C.H. BEST. 1953. Insulin as a growth hormone. Br. Med. J. (Aug. 15): 353-358.
45. ZAPF, J. 1997. The IGF-insulin relationship. J. Pediatr. Endocrinol. Metabol. 10: 87-95.
46. CLEMMONS, D.R. & L.E. UNDERWOOD. 1991. Nutritional regulation of IGF-I and IGF binding proteins. Ann. Rev. Nutr. 11: 393-412.
47. WERNER, H. & D. LEROITH. 1996. The role of the insulin-like growth factor system in human cancer. Adv. Cancer Res. 68: 183-223.
48. STEWART, C.E. & P. ROTWEIN. 1996. Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol. Rev. 76: 1005-1026.
49. DICKSON, R.B. & M.E. LIPPMAN. 1995. Growth factors in breast cancer. Endocr. Rev. 16: 559-589.
50. BASERGA, R. 1995. The insulin-like growth factor I receptor: a key to tumor growth? Cancer Res. 55: 249-252.
51. BERNS, E.M., J.G. KLIJN, S.I. VAN, et al. 1992. Sporadic amplification of the insulin-like growth factor 1 receptor gene in human breast tumors. Cancer Res. 52: 1036-1039.
52. THISSEN, J.P., J.M. KETELSLEGERS & L.E. UNDERWOOD. 1994. Nutritional regulation of the insulin-like growth factors. Endocr. Rev. 15: 80-101.
53. BAXTER, R.C. & J.R. TURTLE. 1978. Regulation of hepatic growth hormone receptors by insulin. Biochem. Biophys. Res. Commun. 84: 350-357.
54. PLYMATE, S.R., R.E. JONES, L.A. MATEJ & K.E. FRIEDL. 1988. Regulation of sex hormone binding globulin (SHBG) production in Hep G2 cells by insulin. Steroids 52: 339-340.
55. CRAVE, J.C., H. LEJEUNE, C. BREBANT, et al. 1995. Differential effects of insulin and insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma-derived (Hep G2) cells. J. Clin. Endocrinol. Metab. 80: 1283-1289.
56. STEIN, P., L.E. BUSSMANN & M. TESONE. 1995. In vivo regulation of the steroidogenic activity of rat luteal cells by insulin. J. Steroid Biochem. Mol. Biol. 52: 329-335.
57. HANKINSON, S.E., W.C. WILLETT, G.A. COLDITZ, et al. 1998. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351: 1393-1396.
58. TONIOLO, P., P.F. BRUNING, A. AKHMEDKHANOV, et al. 2000. Serum insulin-like growth factor-I and breast cancer. Int. J. Cancer 88: 828-832.
59. MUTI, P., T. QUATTRIN, B. GRANT, et al. 2002. Fasting glucose, insulin and insulin-like growth factor (IGF)-I pattern in relation to breast cancer risk: a prospective study. Cancer Epidemiol. Biomarkers Prev. 11: 1361-1366.
60. KRAJCIK, R.A., N.D. BOROFSKY, S. MASSARDO & N. ORENTREICH. 2002. Insulin-like growth factor I (IGF), IGF-binding proteins, and breast cancer. Cancer Epidemiol. Biomarkers Prev. 11: 1566-1573.
61. JERNSTRÖM, H., C. DEAL, F. WILKIN, et al. 2001. Genetic and nongenetic factors associated with variation of plasma levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in healthy premenopausal women. Cancer Epidemiol. Biomarkers Prev. 10: 377-384.
62. WARBURG, O. 1956. On the origin of cancer cells. Science 123: 309-314.
63. BERRINO, F., C. BELLATI, G. SECRETO, et al. 2001. Reducing bioavailable sex hormones through a comprehensive change in diet: the Diet and Androgens (DIANA) Randomized Trial Cancer. Epidemiol. Biomarkers Prev. 10: 25-33.
64. ROSE, D.P., J.M. CONNOLLY, R.T. CHLEBOWSKI, et al. 1993. The effects of a low-fat dietary intervention and tamoxifen adjuvant therapy on the serum estrogen and sex hormone-binding globulin concentrations of postmenopausal breast cancer patients. Breast Cancer Res. Treat. 27: 253-262.
65. SCHAEFER, E.J., A.H. LICHTENSTEIN, S. LAMON-FAVA, et al. 1995. Body weight and low-density lipoprotein cholesterol changes after consumption of a low-fat ad libitum diet. J. Am. Med. Assoc. 274: 1450-1455.
66. SHAH, M., P. MCGOVERN, S. FRENCH & J. BAXTER. 1994. Comparison of a low-fat, ad libitum complex-carbohydrate diet with a low-energy diet in moderately obese women. Am. J. Clin. Nutr. 59: 980-984.
67. GRENMAN, S., T. RONNEMAA, K. IRJALA, et al. 1986. Sex steroid, gonadotropin, cortisol, and prolactin levels in healthy, massively obese women: correlation with abdominal fat cell size and effect of weight reduction. J. Clin. Endocrinol. Metab. 63: 1257-1261.
68. SVENDSEN, O.L., C. HASSAGER & C. CHRISTIANSEN. 1995. The response to treatment of overweight in postmenopausal women is not related to fat distribution. Int. J. Obes. Relat. Metab. Disord. 19: 496-502.
69. KIDDY, D.S., D. HAMILTON-FAIRLEY, M. SEPPALA, et al. 1989. Diet-induced changes in sex hormone binding globulin and free testosterone in women with normal or polycystic ovaries: correlation with serum insulin and insulin-like growth factor-I. Clin. Endocrinol. 31: 757-763.
70. GUZICK, D.S., R. WING, D. SMITH, et al. 1994. Endocrine consequences of weight loss in obese, hyperandrogenic, anovulatory women. Fertil. Steril. 61: 598-604.
71. CRAVE, J.C., S. FIMBEL, H. LEJEUNE, et al. 1995. Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women. J. Clin. Endocrinol. Metab. 80: 2057-2062.
72. O'DEA, J.P., R.G. WIELAND, M.C. HALLBERG, et al. 1979. Effect of dietary weight loss on sex steroid binding sex steroids, and gonadotropins in obese postmenopausal women. J. Lab. Clin. Med. 93: 1004-1008.
73. BATES, G.W. & N.S. WHITWORTH. 1982. Effect of body weight reduction on plasma androgens in obese, infertile women. Fertil. Steril. 38: 406-409.
74. INGRAM, D.M., F.C. BENNETT, D. WILLCOX & N. DE KLERK. 1987. Effect of low-fat diet on female sex hormone levels. J. Natl. Cancer Inst. 79: 1225-1229.
75. PRENTICE, R., D. THOMPSON, C. CLIFFORD, et al. 1990. Dietary fat reduction and plasma estradiol concentration in healthy postmenopausal women. The Women's Health Trial Study Group. J. Natl. Cancer Inst. 82: 129-134.