Amphiregulin acts as an autocrine survival factor for adult sensory neurons

NeuroReport

Volumn 16, Issue 3, 2005, Pages 213-218

  Nilsson, Anna ^a   Kanje, Martin ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Amphiregulin; Apoptosis; Axons; Axotomy; EGF; EGF receptor; Nerve growth factors; Nerve regeneration; Sensory neurons; Spinal ganglia

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; AMPHIREGULIN; BIOLOGICAL FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; SURVIVAL FACTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL COUNT; CELL SIZE; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; GROWTH INHIBITION; MOUSE; NERVE CELL NECROSIS; NERVE FIBER GROWTH; NERVE FIBER TRANSECTION; NERVE REGENERATION; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; SENSORY NERVE CELL; SPINAL GANGLION; STAINING;

ANIMALS; AXONS; CELL SURVIVAL; CELLS, CULTURED; CULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; FEMALE; GANGLIA, SPINAL; GLYCOPROTEINS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NEURONS, AFFERENT; RECEPTOR, EPIDERMAL GROWTH FACTOR; TYRPHOSTINS;

EID: 14944350077     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200502280-00002     Document Type: Article

References (18)

1. Nilsson A and Kanje M. Early changes in gene expression in the dorsal root ganglia after transection of the sciatic nerve; effects of amphiregulin and PAI-1 on regeneration. Mol Brain Res, In press.
2. Brown CL, Meise KS, Plowman GD, Coffey RJ and Dempsey PJ. Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form. J Biol Chem 1998; 273:17258-17268.
3. Dong J, Opresko LK, Dempsey PJ, Lauffenburger DA, Coffey RJ and Wiley HS. Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. Proc Natl Acad Sci USA 1999; 96:6235-6240.
4. Gee JM and Knowlden JM. ADAM metalloproteases and EGFR signalling. Breast Cancer Res 2003; 5:223-224.
5. Maher PA and Schubert D. Schwannoma-derived growth factor interacts with the epidermal growth factor receptor. J Neurochem 1995; 65: 1895-1898.
6. Xian CJ and Zhou XF. Neuronal-glial differential expression of TGF-alpha and its receptor in the dorsal root ganglia in response to sciatic nerve lesion. Exp Neurol 1999; 157:317-326.
7. Huerta JJ, Diaz-Trelles R, Naves FJ, Llamosas MM, Del Valle ME and Vega JA. Epidermal growth factor receptor in adult human dorsal root ganglia. Anat Embryol (Berl) 1996; 194:253-257.
8. Kimura H, Fischer WH and Schubert D. Structure, expression and function of a schwannoma-derived growth factor. Nature 1990; 348: 257-260.
9. Falk A and Frisen J. Amphiregulin is a mitogen for adult neural stem cells. J Neurosci Res 2002; 69:757-762.
10. Kimura H and Schubert D. Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells. J Cell Biol 1992; 116:777-783.
11. Takenouchi T, Kadosaka M, Shin SY and Munekata E. Biological actions of the epidermal growth factors-like domain peptides of mouse schwannoma-derived growth factor and human amphiregulin. J Pept Res 1999; 53:120-125.
12. Tonge D, Edstrom A and Ekstrom P. Use of explant cultures of peripheral nerves of adult vertebrates to study axonal regeneration in vitro. Prog Neurobiol 1998; 54:459-480.
13. Schmued LC and Hopkins KJ, Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 2000; 874:123-130.
14. Shoyab M, McDonald VL, Bradley JG and Todaro GJ. Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. Proc Natl Acad Sci USA 1988; 85: 6528-6532.
15. Wagner M, Weber CK, Bressau F, Greten FR, Stagge V, Ebert M et al. Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells. Gastroenterology 2002; 122: 1898-1912.
16. Gschwind A, Hart S, Fischer OM and Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J 2003; 22:2411-2421.
17. Saito T, Okada S, Ohshima K, Yamada E, Sato M, Uehara Y, Shimizu H, Pessin JE and Mori M. Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF. Endocrinology 2004; 145:4232-4243.
18. Xian CJ, Li L, Deng YS, Zhao SP and Zhou XF. Lack of effects of transforming growth factor-alpha gene knockout on peripheral nerve regeneration may result from compensatory mechanisms. Exp Neurol 2001; 172:182-188.