The P450cam G248E mutant covalently binds its prosthetic heme group

Biochemistry

Volumn 44, Issue 10, 2005, Pages 4091-4099

  Limburg, Julian ^a,b   LeBrun, Laurie A ^a,c   Ortiz De Montellano, Paul R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; CHEMICAL BONDS; IRON; MUTAGENESIS; ORGANIC ACIDS; PEROXIDES; PROTEINS; REACTION KINETICS;

CARBOXYLIC GROUPS; COVALENT BOND; PEROXIDASES; PROSTHETIC HEME;

ENZYMES;

ASPARTIC ACID; CAMPHOR; CARBOXYLIC ACID; CYTOCHROME P450; GLUTAMIC ACID; HEME; IRON; METHYL GROUP; MUTANT PROTEIN; OXIDOREDUCTASE; PRONASE; PUTIDAREDOXIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; CAMPHOR 5 MONOOXYGENASE; CYP4A11 PROTEIN, HUMAN; GLYCINE; ISOENZYME;

ARTICLE; CATALYSIS; COVALENT BOND; KINETICS; PRIORITY JOURNAL; SPECTROSCOPY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMICAL MODEL; CHEMICAL STRUCTURE; COMPARATIVE STUDY; GENETICS; HUMAN; HYDROXYLATION; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; RAT;

DRYOBALANOPS; MAMMALIA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CAMPHOR; CAMPHOR 5-MONOOXYGENASE; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; GLUTAMIC ACID; GLYCINE; HEME; HUMANS; HYDROXYLATION; ISOENZYMES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RATS;

EID: 14844354133     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047686i     Document Type: Article

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