Different inhibitory effects in the early and late phase of treatment with KAT-681, a liver-selective thyromimetic, on rat hepatocarcinogenesis induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation

Toxicological Sciences

Volumn 84, Issue 1, 2005, Pages 22-28

  Hayashi, Morimichi ^a,b   Tamura, Toru ^a   Kuroda, Junji ^a   Ohnota, Hideki ^a   Shibata, Nobuo ^a   Akahane, Masuo ^a   Kashida, Yoko ^c   Mitsumori, Kunitoshi ^c  

^a KISSEI PHARMACEUTICAL CO LTD   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Cell proliferation; Chemoprevention; Hepatocarcinogenesis; Rat; Thyroid hormone; Thyromimetic

Indexed keywords

CYCLINE; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; KAT 681; N (2 FLUORENYL)ACETAMIDE; N [4 [3 [(4 FLUOROPHENYL)HYDROXYMETHYL] 4 HYDROXYPHENOXY] 3,5 DIMETHYLPHENYL]MALONAMIC ACID; THYROMIMETIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CARCINOMA; LIVER CELL; LIVER WEIGHT; LONG TERM CARE; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; SHORT COURSE THERAPY;

2-ACETYLAMINOFLUORENE; ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BODY WEIGHT; CARCINOGENS; CELL PROLIFERATION; DIETHYLNITROSAMINE; EATING; GLUTATHIONE TRANSFERASE; HEPATECTOMY; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS; MALE; MALONATES; ORGAN SIZE; PHENYL ETHERS; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, INBRED F344; THYROID HORMONES;

EID: 14844328065     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi044     Document Type: Article

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