Analysis of normal and mutant iduronate-2-sulphatase conformation

Biochemical Journal

Volumn 386, Issue 2, 2005, Pages 395-400

  Parkinson Lawrence, Emma ^a   Turner, Christopher ^a   Hopwood, John ^a,b   Brooks, Doug ^a,b  

^a WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Heat denaturation; Iduronate 2 sulphatase (IDS); Mucopolysaccharidosis type II (MPS II); Mutant protein; Protein conformation

Indexed keywords

AMINO ACIDS; ANTIBODIES; CATALYSIS; CONFORMATIONS; POLYSACCHARIDES;

EPITOPES; GLYCOSYLATION; HEPARAN SULFATE; THERMAL ENERGY;

ENZYMES;

DERMATAN SULFATE; EPITOPE; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; IDURONATE 2 SULFATASE; LYSOSOME ENZYME; MONOCLONAL ANTIBODY; MUTANT PROTEIN; POLYCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ANTIGENICITY; ARTICLE; ENERGY; ENZYME CONFORMATION; ENZYME DENATURATION; ENZYME MECHANISM; EPITOPE MAPPING; GLYCOSYLATION; HUMAN; HUMAN CELL; HUNTER SYNDROME; IMMUNOREACTIVITY; MAMMAL; MOLECULAR PROBE; PRIORITY JOURNAL; PROTEIN FAMILY; SEQUENCE HOMOLOGY; THERMAL ENERGY;

AGE OF ONSET; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CENTRAL NERVOUS SYSTEM; CHILD, PRESCHOOL; CHO CELLS; CRICETINAE; CRICETULUS; ENDOTHELIAL CELLS; EPITOPE MAPPING; EPITOPES; HEAT; HUMANS; IDURONATE SULFATASE; LEUKOCYTES; LIVER; MANNOSYL-GLYCOPROTEIN ENDO-BETA-N-ACETYLGLUCOSAMINIDASE; MICE; MODELS, MOLECULAR; MUCOPOLYSACCHARIDOSIS II; MUTATION; PHENOTYPE; PROTEIN CONFORMATION; PROTEIN DENATURATION; SHEEP;

MAMMALIA;

EID: 14844325339     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040739     Document Type: Article

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