Selective release of ATP from sympathetic nerves of rat vas deferens by the toxin TsTX-I from Brazilian scorpion Tityus serrulatus

British Journal of Pharmacology

Volumn 144, Issue 4, 2005, Pages 519-527

  Conceição, Isaltino M ^a,b   Jurkiewicz, Aron ^b   Fonseca, Daniela R ^a   Opperman, Andrea R ^a   Freitas, Thalma A ^a,c   Lebrun, Ivo ^a   Garcez Do Carmo, Lúcia ^b  

^a INSTITUTO BUTANTAN   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSIDADE METODISTA DE SÃO PAULO   (Brazil)

Author keywords

Adrenoceptors; ATP; Cotransmission; Toxin TsTX I; VAS deferens

Indexed keywords

ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; BARIUM CHLORIDE; NORADRENALIN; OMEGA CONOTOXIN GVIA; OMEGA CONOTOXIN MVIIC; PRAZOSIN; PURINE P2X RECEPTOR; RESERPINE; SCORPION VENOM; SURAMIN; TETRODOTOXIN; TITYUS TOXIN; TITYUS TOXIN TSTX I; UNCLASSIFIED DRUG; VERATRIDINE;

ANIMAL TISSUE; ARTICLE; MUSCLE CONTRACTILITY; NERVE ENDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SCORPION; SYMPATHETIC NERVE; TOXIN ANALYSIS; VAS DEFERENS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM CHANNEL BLOCKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEUROTRANSMITTER AGENTS; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC; RECEPTORS, PURINERGIC; SCORPION VENOMS; SCORPIONS; SYMPATHECTOMY; SYMPATHETIC NERVOUS SYSTEM; TIME FACTORS; VAS DEFERENS; VERATRIDINE;

EID: 14844322859     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706062     Document Type: Article

References (53)

1. ARISPE, N., JAIMOVICH, E., LIBERONA, J.L. & ROJAS, E. (1988). Use of selective toxins to separate surface and tubular sodium currents in frog skeletal muscle fibers. Pflugers Arch., 411, 1-7.
2. + channel. J. Biol. Chem., 257, 12553-12558.
3. - channel in muscle, with a selectivity for channels in the surface membrane. Pflugers Arch., 400, 22-27.
4. + channel from rat brain. EMBO J., 2, 915-920.
5. 2- channel blockers on noradrenaline release and purinergic neuroeffector transmission in rat tail artery. Br. J. Pharmacol., 126, 11-18.
6. BROCK, J.A., DUNN, W.R., BOYD, N.S. & WONG, D.K. (2000). Spontaneous release of large packets of noradrenaline from sympathetic nerve terminals in rat mesenteric arteries in vitro. Br. J. Pharmacol., 131, 1507-1511.
7. BROCK, J.A., MCLACHLAN, E.M., JOBLING, P. & LEWIS, R.J. (1995). Electrical activity in rat tail artery during asynchronous activation of postganglionic nerve terminals by ciguatoxin-1. Br. J. Pharmacol., 116, 2213-2220.
8. BROCK, J.A., MCLACHLAN, E.M. & RAYNER, S.E. (1997). Contribution of alpha-adrenoceptors to depolarization and contraction evoked by continuous asynchronous sympathetic nerve activity in rat tail artery. Br J Pharmacol., 120, 1513-1521.
9. BURNSTOCK, G. (2004). Cotransmission. Curr. Opin. Pharmacol., 4, 47-52.
10. CARVALHO, F.F., NENCIONI, A.L., LEBRUN, I., SANDOVAL, M.R. & DORCE, V.A. (1998). Behavioral, electroencephalographic, and histopathologic effects of a neuropeptide isolated from Tityus serrulatus scorpion venom in rats. Pharmacol. Biochem. Behav., 60, 7-14.
11. CATTERALL, W.A. & COPPERSMITH, J. (1981). Pharmacological properties of sodium channels in cultured rat heart cells. Mol. Pharmacol., 20, 533-542.
12. CATTERALL, W.A., STRIESSNIG, J., SNUTCH, T.P. & PEREZ-REYES, E. (2003). International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels. Pharmacol. Rev., 55, 579-581.
13. CONCEIÇÂO, I.M., LEBRUN, I., CANO-ABAD, M., GANDIA, L., HERNANDEZ-GUIJO, J.M., LOPEZ, M.G., VILLARROYA, M., JURKIEWICZ, A. & GARCIA, A.G. (1998). Synergism between toxin-gamma from Brazilian scorpion Tityus serrulatus and veratridine in chromaffin cells. Am. J. Physiol., 274, C1745-C1754.
14. COURAUD, F. & JOVER, E. (1984). Mechanism of action of scorpion toxins. In: Handbook of Natural Toxins, ed. Tu, A.T. pp. 659-678. New York: Marcel Dekker.
15. COUTO, A.S., MORAES-SANTOS, T., AZEVEDO, A.D., ALMEIDA, A.P. & FREIRE-MAIA, L. (1992). Effects of toxin Ts-gamma, purified from Tityus serrulatus scorpion venom, on the isolated rat atria. Toxicon, 30, 339-343.
16. DEBIN, J.A., MAGGIO, J.E. & STRICHARTZ, G.R. (1993). Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. Am. J. Physiol, 264, C361-C369.
17. DORCE, V.A. & SANDOVAL, M.R. (1994). Effects of Tityus serrulatus crude venom on the GABAergic and dopaminergic systems of the rat brain. Toxicon, 32, 1641-1647.
18. DRUMOND, Y.A., COUTO, A.S., MORAES-SANTOS, T., ALMEIDA, A.P. & FREIRE-MAIA, L. (1995). Effects of toxin Ts-gamma and tityustoxin purified from Tityus serrulatus scorpion venom on isolated rat atria. Comp. Biochem. Physiol. C., 111, 183-190.
19. ELLIS, J.L. & BURNSTOCK., G. (1989). Angiotensin neuromodulation of adrenergic and purinergic co-transmission in the guinea-pig vas deferens. Br. J. Pharmacol., 97, 1157-1164.
20. FEDAN, J.S. & BESSE, J.C. (1980). Distensibility and responsiveness of the rat seminal vesicle: effects of denervation and pretreatment of animals with 6-hydroxydopamine and reserpine. J. Pharmacol. Exp. Ther., 214, 472-477.
21. FERNANDES DE OLIVEIRA, J., TEIXEIRA, C.E., ARANTES, E.C., DE NUCCI, G. & ANTUNES, E. (2003). Relaxation of rabbit corpus cavernosum by selective activators of voltage-gated sodium channels: role of nitric oxide-cyclic guanosine monophosphate pathway. Urology, 62, 581-588.
22. GARCIA, M.L., HANNER, M., KNAUS, H.G., SLAUGHTER, R. & KACZOROWSKI, G.J. (1999). Scorpion toxins as tools for studying potassium channels. Methods Enzymol., 294, 624-639.
23. 2+ channel. Eur. J. Pharmacol., 321, 217-223.
24. HOYLE, C.H.V. & BURNSTOCK, G. (1985). Atropine-resistant excitatory junction potentials in rabbit bladder are blocked by α,β-methylene ATP. Eur. J. Pharmacol., 114, 239-240.
25. JONAS, P., VOGEL, W., ARANTES, E.C. & GIGLIO, J.R. (1986). Toxin gamma of the scorpion Tityus serrulatus modifies both activation and inactivation of sodium permeability of nerve membrane. Pflugers Arch., 407, 92-99.
26. JURKIEWTCZ, A., ABDO, A.O., JURKIEWICZ, N.H., GUEDES, A.O. & SOUCCAR, C. (1976). Relative responsiveness (rho): a critical analysis of a new method in receptor differentiation. Gen. Pharmacol., 7, 93-101.
27. JURKIEWICZ, A. & JURKIEWICZ, N.H. (1976). Dual effect of alpha-adrenoceptor antagonists in rat isolated vas deferens. Br. J. Pharmacol., 56, 169-178.
28. JURKIEWICZ, A., JURKIEWICZ, N.H., BARROS, G.G. & VALLE, J.R. (1969). Relative responsiveness (rho) of pharmacological receptor systems in the rat vas deferens. Pharmacology, 2, 89-99.
29. KASUYA, Y., GOTO, K., HASHIMOTO, H., WATANABE, H., MUNAKATA, H. & WATANABE, M. (1969). Nonspecific denervation supersensitivity in the rat vas deferens 'in vitro'. Eur. J. Pharmacol., 8, 177-184.
30. KIRKPATRICK, K. & BURNSTOCK, G. (1987). Sympathetic nerve-mediated release of ATP from the guinea-pig vas deferens is unaffected by reserpine. Eur. J. Pharmacol., 138, 207-214.
31. 3H-noradrenaline and enhancement of transmitter overflow elicited by nerve stimulation. Naunyn Schmiedebergs Arch. Pharmacol., 287, 243-259.
32. LEVITT, B., HEAD, R.J. & WESTFALL, D.P. (1984). High-pressure liquid chromatographic-fluorometric detection of adenosine and adenine nucleotides: application to endogenous content and electrically induced release of adenyl purines in guinea pig vas deferens. Anal. Biochem., 137, 93-100.
33. + channels. Circ. Res., 80, 363-369.
34. MATOS, I.M., TEIXEIRA, M.M., LEITE, R. & FREIRE-MAIA, L. (1999). Pharmacological evidence that neuropeptides mediate part of the actions of scorpion venom on the guinea pig ileum. Eur. J. Pharmacol., 368, 231-236.
35. OHIZUMI, Y. (1997). Application of physiologically active substances isolated from natural resources to pharmacological studies. Jpn. J. Pharmacol., 73, 263-289.
36. POSSANI, L.D., ALAGON, A.C., FLETCHER JR, P.L. & ERICKSON, B.W. (1977). Purification and properties of mammalian toxins from the venom of Brazilian Scorpion Tityus serrulatus Lutz and Mello. Arch. Biochem. Biophys., 180, 394-403.
37. 1-adrenoceptor and neuronal uptake blockade. Br. J. Pharmacol., 127, 1832-1836.
38. PUPO, A.S., JURKIEWICZ, N.H. & JURKIEWICZ, A. (1997). Functional change of the balance between alpha 1A and alpha 1B adrenoceptor populations after transplantation of the vas deferens to the intestine. Ann. NY Acad. Sci., 812, 193-195.
39. 2+ channel currents in rat cerebellar granule neurons. J. Neurosci., 15, 2995-3012.
40. SILVEIRA, N.P., MORAES-SANTOS, T., AZEVEDO, A.D. & FREIREMAIA, L. (1991). Effects of Tityus serrulatus scorpion venom and one of its purified toxins (toxin gamma) on the isolated guinea-pig heart. Comp. Biochem. Physiol. C, 98, 329-336.
41. SNEDDON, P. & WESTFALL, D.P. (1984). Pharmacological evidence that adenosine triphosphate and noradrenaline are co-transmitters in the guinea-pig vas deferens. J. Physiol., 347, 561-580.
42. SNEDDON, P., WESTFALL, D.P., COLBY, J. & FEDAN, J.S. (1984). A pharmacological investigation of the biphasic nature of the contractile response of rabbit and rat vas deferens to field stimulation. Life Sci., 35, 1903-1912.
43. STJÄRNE, L. (2001). Novel dual 'small' vesicle model of ATP- and noradrenaline-mediated sympathetic neuromuscular transmission. Auton. Neurosci., 87, 16-36.
44. TODOROV, L.D., BJUR, R.A. & WESTFALL, D.P. (1994). Temporal dissociation of the release of the sympathetic co-transmitters ATP and noradrenaline. Clin. Exp. Pharmacol. Physiol., 21, 931-932.
45. TODOROV, L.D., MIHAYLOVA-TODOROVA, S.T., BJUR, R.A. & WESTFALL, D.P. (1999). Differential cotransmission in sympathetic nerves: role of frequency of stimulation and prejunctional auto-receptors. J. Pharmacol. Exp. Ther., 290, 241-246.
46. TODOROV, L.D., MIHAYLOVA-TODOROVA, S., CRAVISO, G.L., BJUR, R.A. & WESTFALL, D.P. (1996). Evidence for the differential release of the cotransmitters ATP and noradrenaline from sympathetic nerves of the guinea-pig vas deferens. J. Physiol., 496 (Part 3), 731-748.
47. TODOROV, L.D., MIHAYLOVA-TODOROVA, S., WESTFALL, T.D., SNEDDON, P., KENNEDY, C., BJUR, R.A. & WESTFALL, D.P. (1997). Neuronal release of soluble nucleotidases and their role in neurotransmitter inactivation. Nature, 387, 76-79.
48. TRACHTE, G.J., BINDER, S.B. & PEACH, M.J. (1989). Indirect evidence for separate vesicular neuronal origins of norepinephrine and ATP in the rabbit vas deferens. Eur. J. Pharmacol., 164, 425-433.
49. 2+ release channels (ryanodine receptors) of cardiac and skeletal muscle. J. Gen. Physiol., 111, 679-690.
50. a+ channels in neuroblastoma cells. Pflugers Arch., 401, 297-303.
51. YANG, X. & CHIBA, S. (2000). Differential effects of omega-conotoxin GVIA, tetrodotoxin and prolonged cold storage on purinergic and adrenergic transmission in isolated canine splenic artery. J. Cardiovasc. Pharmacol., 36, S5-S8.
52. YATANI, A., KIRSCH, G.E., POSSANI, L.D. & BROWN, A.M. (1988). Effects of New World scorpion toxins on single-channel and whole cell cardiac sodium currents. Am. J. Physiol., 254, H443-H451.
53. ZUCKER, R.S. (1996). Exocytosis: a molecular and physiological perspective. Neuron. 17, 1049-1055.