ω-Conotoxins block neurotransmission in the rat vas deferens by binding to different presynaptic sites on the N-type Ca2+ channel

European Journal of Pharmacology

Volumn 321, Issue 2, 1997, Pages 217-223

  Hirata, Hanako ^a   Albillos, Almudena ^b   Fernández, Francisco ^b   Medrano, José ^b   Jurkiewicz, Aron ^a   García, Antonio G ^b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Agatoxin IVA; Conotoxin MVIIA; Conotoxin MVIIC; Ca2+ channel; Purinergic neurotransmission; Vas deferens

Indexed keywords

CALCIUM; CALCIUM CHANNEL; OMEGA CONOTOXIN; OMEGA CONOTOXIN GVIA; OMEGA CONOTOXIN MVIIA; OMEGA CONOTOXIN MVIIC;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; MALE; MUSCLE TWITCH; NEUROTRANSMISSION; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RAT; VAS DEFERENS;

ANIMALS; BINDING SITES; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; ELECTRIC STIMULATION; MALE; MUSCLE CONTRACTION; NEUROTOXINS; OMEGA-AGATOXIN IVA; OMEGA-CONOTOXIN GVIA; OMEGA-CONOTOXINS; PEPTIDES; RATS; RATS, WISTAR; SPIDER VENOMS; SYNAPTIC TRANSMISSION; VAS DEFERENS;

EID: 0031046079     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00951-X     Document Type: Article

References (22)

1. Adams, M.E., R.A. Myers, J.S. Imperial and B.M. Olivera, 1993, Toxityping rat brain calcium channels with ω-toxins from spider and cone snail venoms, Biochemistry 32, 12566.
2. Albillos, A., L. Gandia, P. Michelena, J.A. Gilabert, M. Del Valle, E. Carbone and A.G. Garcia, 1996, The mechanism of calcium channel facilitation in bovine chromaffin cells, J. Physiol. 494, 687.
3. Ballesta, J.J., M. Palmero, M.J. Hidalgo, L.M. Gutiérrez, J.A. Reig, S. Viniegra and A.G. García, 1989, Separate binding and functional sites for ω-conotoxin and nitrendipine suggest two types of calcium channels in bovine chromaffin cells, J. Neurochem. 53, 1050.
4. Boot, J.R., 1994, Differential effects of ω-conotoxin GVIA and MVIIC on nerve stimulation induced contractions of guinea-pig ileum and rat vas deferens, Eur. J. Pharmacol. 258, 155.
5. De Lucca, A., C.G. Li, M.J. Reid, P. Thaina and H.K. Wong-Dusting, 1990, Effects of omega-conotoxin GVIA on autonomic neuroeffector transmission in various tissues, Br. J. Pharmacol. 101, 437.
6. Fenwick, E.M., A. Marty and E. Neher, 1982, Sodium and calcium channels in bovine chromafin cells, J. Physiol. 331, 599.
7. Fox, J.A., 1995, Irreversible and reversible blockade of LMR32 calcium channel currents by synthetic MVIIA and iodinated MVIIC omega-conopeptides, Pflügers Arch. 429, 873.
8. 2+ channels, Neuron 9, 69.
9. 2+ channels dominate the control of secretion in bovine chromaffin cells, FEBS Lett. 349, 331.
10. Lundy, P.M. and R. Frew, 1994, Effect of ω-agatoxin-IVA on autonomic neurotransmission, Eur. J. Pharmacol. 262, 79.
11. Maggi, C.A., R. Patacchini, P. Santicioli, I. Th. Lippe, S. Guliani, P. Geppetti, E. Del Bianco, S. Selleri and A. Meli, 1988, The effect of omega conotoxin GVIA, a peptide modulator of the N-type voltage sensitive calcium channels, on motor responses produced by activation of efferent and sensory nerves in mammalian smooth muscle, Naunyn-Schmiedeberg's Arch. Pharmacol. 338, 107.
12. 2+ channels in rat insulinoma RINm5F cells by ω-agatoxin IVA and ω-conotoxin MVIIC, Pflügers Arch. 429, 762.
13. McCleskey, E.W., A.P. Fox, D.H. Feldman, L.J. Cruz, B.M. Olivera, R.W. Tsien and D. Hoshikami, 1987, ω-Conotoxin: direct and persistent blockade of specific of calcium channels in neurons but not in muscle, Proc. Natl. Acad. Sci. USA 84, 4327.
14. Mintz, I.M., V.I. Venema, K.M. Swiderek, T.D. Lee, B.P. Bean and M.E. Adams, 1992, P-type calcium channels blocked by the spider toxin ω-Aga-IVA, Nature 335, 827.
15. Olivera, B.M., G. Miljanich, J. Ramachandran and M.E. Adams, 1994, Calcium channel diversity and neurotransmitter release: the ω-conotoxins and ω-agatoxins, Annu. Rev. Biochem. 63, 823.
16. 2+ channel currents in rat cerebellar granule neurons, J. Neurosci. 15, 2995.
17. 125I]omega-conotoxin MVIIA binding to rat neocortical membranes, Neurosci. Lett. 161, 113.
18. Swartz, K.J., I.M. Mintz, L.M. Boland and B.P. Bean, 1993, Block of calcium channels in central and peripheral rat neurons by ω-conotoxin-MVIIC, Soc. Neurosci. Abstr. 19, 1478.
19. Vega, T., R. De Pascual, O. Bulbena, A.G. García, 1995, Effects of ω-toxins on noradrenergic neurotransmission in beating guinea-pig atria, Eur. J. Pharmacol. 276, 231.
20. Wagner, J.A., A.M. Snowman, A. Bismas, B.M. Olivera and S.H. Snyder, 1988, ω-conotoxin GVIA binding to a high-affinity receptor in brain: characterization, calcium sensitivity and solubilization, J. Neurosci. 8, 3354.
21. 2+ channel and the cation sensitivity of omega-conotoxin GVIA binding, Neuropharmacology 32, 1127.
22. 2+ channels in supporting hippocampal synaptic transmission, Science 264, 107.