Immunosuppression and gingival overgrowth: Gene and protein expression profiles of collagen turnover in FK506-treated human gingival fibroblasts

Journal of Clinical Periodontology

Volumn 32, Issue 2, 2005, Pages 167-173

  Gagliano, Nicoletta ^a,b   Moscheni, Claudia ^a   Dellavia, Claudia ^a   Stabellini, Giordano ^a   Ferrario, Virgilio F ^a   Gioia, Magda ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Dept of Human Morphology LITA ^*  (Italy)

Author keywords

Collagen turnover; FK506; Gingival overgrowth

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1; GELATINASE A; IMMUNOSUPPRESSIVE AGENT; INTERSTITIAL COLLAGENASE; MESSENGER RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; TSUKUBAENOLIDE;

ARTICLE; CELL PROLIFERATION; COLLAGEN METABOLISM; COMPARATIVE STUDY; CONTROLLED STUDY; DOT HYBRIDIZATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ASSAY; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION PROFILING; GINGIVA OVERGROWTH; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; MOLECULAR BIOLOGY; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN MODIFICATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; ZYMOGRAPHY;

ADULT; ANALYSIS OF VARIANCE; CELL PROLIFERATION; COLLAGEN; FEMALE; FIBROBLASTS; GINGIVAL OVERGROWTH; HUMANS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TACROLIMUS;

EID: 14844312004     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2005.00654.x     Document Type: Article

References (29)

1. Bader, G., Lejeune, S. & Messner, M. (1998) Reduction of cyclosporine-induced gingival overgrowth following a change to tacrolimus. A case history involving a liver transplant patient. Journal of Periodontology 69, 729-732.
2. Bicknell, G. R., Williams, S. T., Shaw, J. A., Pringle, J. H., Furness, P. N. & Nicholson, M. L. (2000) Differential effects of cyclosporin and tacrolimus on the expression of fibrosis-associated genes in isolated glomeruli from renal transplants. British Journal of Surgery 87, 1569-1575.
3. Birkedal-Hansen, H. (1993) Role of matrix metalloproteinases in human periodontal diseases. Journal of Periodontology 64, 474-484.
4. Bolzani, G., Della Coletta, R., Junior, H. M., De Almeida, O. P. & Graner, E. (2000) Cyclosporin A inhibits production and activity of matrix metalloproteinases by gingival fibroblasts. Journal of Periodontal Research 35, 51-58.
5. Border, W. A. & Ruoslahti, E. (1992) Transforming growth factor-β in disease: the dark side of tissue repair. Journal of Clinical Investigation 90, 1-7.
6. Brew, K., Dinakarpandian, D. & Nagase, H. (2000) Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochimica et Biophysica Acta 1477, 267-283.
7. Busque, S., Demers, P., St-Louis, G., Boily, J. G., Tousignant, J., Lemieux, F., Smeesters, C., Corman, J. & Daloze, P. (1998) Conversion from Neoral (cyclosporine) to tacrolimus of kidney transplant recipients for gingival hyperplasia or hypertrichosis. Transplantation Proceedings 30, 1247-1248.
8. Faulds, D., Goa, K. L. & Benfeld, P. (1993) Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders. Drugs 45, 953-1040.
9. Fu, E., Nieh, S., Chang, H. L. & Wang, S. L. (1995) Dose-dependent gingival overgrowth induced by cyclosporin in rats. Journal of Periodontology 66, 594-598.
10. Gagliano, N., Arosio, B., Grizzi, F., Masson, S., Tagliabue, J., Dioguardi, N., Vergani, C. & Annoni, G. (2002) Reduced collagenolytic activity of matrix metalloproteinases and development of liver fibrosis in the aging rat. Mechanisms of Ageing and Development 123, 413-425.
11. Gagliano, N., Moscheni, C., Dellavia, C., Torri, C., Stabellini, G., Ferrario, V. F. & Gioia, M. (2004) Effect of cyclosporin A on human gingival fibroblast collagen turnover in relation to the development of gingival overgrowth: an in vitro study. Biomedicine and Pharmacotherapy 58, 231-238.
12. Ginevri, F., Gusmano, R., Altieri, P., Valenti, F., Oleggini, R., Giampuzzi, M., Caridi, G., Ravazzolo, R. & Ghiggeri, G. M. (1998) Expression of collagen by renal fibroblasts treated with FK 506 in vitro. Transplantation Proceedings 30, 957-958.
13. Hassell, T. M. & Hefti, A. F. (1991) Drug-induced gingival overgrowth: old problem, new problem. Critical Reviews in Oral Biology and Medicine 2, 103-137.
14. Hyland, P. L., Traynor, P. S., Myrillas, T. T., Marley, J. J., Linden, G. J., Winter, P., Leadbetter, N., Cawston, T. E. & Irwin, C. (2003) The effects of cyclosporin on the collagenolytic activity of gingival fibroblasts. Journal of Periodontology 74, 437-445.
15. Kataoka, M., Shimizu, Y., Kunikiyo, K., Asahara, Y., Yamashita, K., Ninomiya, M., Morisaki, I., Ohsaki, Y., Kido, J. I. & Nagata, T. (2000) Cyclosporin A decreases the degradation of type I collagen in rat gingival overgrowth. Journal of Cell Physiology 182, 351-358.
16. Kleiner, D. E. & Stetler-Stevenson, W. G. (1994) Quantitative zymography: detection of picogram quantities of gelatinases. Analytical Biochemistry 218, 325-329.
17. McKaig, S. J., Kelly, D. & Shaw, L. (2002) Investigation of the effect of FK506 (tacrolimus) and cyclosporin on gingival overgrowth following paediatric liver transplantation. International Journal of Paediatric Dentistry 12, 398-403.
18. Migita, K., Tanaka, H., Okamoto, K., Yoshikawa, N., Ichinose, Y., Urayama, S., Yamasaki, S., Ida, H., Kawabe, Y., Kawakami, A. & Eguchi, K. (2000) FK506 augments glucocorticoid-mediated cyclooxygenase-2 down-regulation in human rheumatoid synovial fibroblasts. Laboratory Investigation 80, 135-141.
19. Mohamed, M. A., Burt, A. D., Robertson, H., Kirby, J. A. & Talbot, D. (2001) TGF-beta expression in protocol transplant liver biopsies: a comparative study between cyclosporine-A (CyA) and tacrolimus (FK 506) immunosuppression. Transplantation Proceedings 33, 1378-1380.
20. Mohamed, M. A., Robertson, H., Booth, T. A., Balupuri, S., Kirby, J. A. & Talbot, D. (2000) TGF-beta expression in renal transplant biopsies: a comparative study between cyclosporin-A and tacrolimus. Transplantation 69, 1002-1005.
21. Sakai, T. & Gross, J. (1967) Some properties of the products of reaction of tadpole collagenase with collagen. Biochemistry 6, 518-528.
22. Seymour, R. A. & Jacobs, D. J. (1992) Cyclosporin A and the gingival tissues. Journal of Clinical Periodontology 19, 1-11.
23. Sporn, M. B. & Roberts, A. B. (1990) The transforming growth factor-βs: past, present and future. Annals of the New York Academy of Science 593, 1-6.
24. Stricklin, G. P., Jeffrey, J. J., Roswit, W. T. & Eisen, A. Z. (1983) Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin. Biochemistry 22, 61-68.
25. Tang, L., Ebara, S., Kawasaki, S., Wakabayashi, S., Nikaido, T. & Takaoka, K. (2002) FK506 enhanced osteoblastic differentiation in mesenchimal cells. Cell Biology International 26, 75-84.
26. Tuter, G., Serdar, M. A., Yalim, M., Gurhan, I. S. & Balos, K. (2002) Evaluation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 levels in gingival fibroblasts of cyclosporin A-treated patients. Journal of Periodontology 73, 1273-1278.
27. James, J. A., Boomer, S., Maxwell, A. P., Hull, P. S., Short, C. D., Campbell, B. A. Johnson, R.W, Irwin, C. R., Marley, J. J., Spratt, H. & Linden, G. J. (2000) Reduction in gingival overgrowth associated with conversion from cyclosporin A to tacrolimus. Journal of Clinical Periodontology 27, 144-148.
28. James, J. A., Irwin, C. R. & Linden, G. J. (1998) Gingival fibroblast response to cyclosporin A and transforming growth factor β1. Journal of Periodontal Research 33, 40-48.
29. Woessner, F. J. (1991) Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB Journal 5, 2145-2154.