Effect of the growth promoter avilamycin on emergence and persistence of antimicrobial resistance in enteric bacteria in the pig

Journal of Applied Microbiology

Volumn 98, Issue 3, 2005, Pages 564-571

  Delsol, Anne A ^a   Randall, L ^b   Cooles, S ^b   Woodward, M J ^b   Sunderland, J ^c   Roe, J M ^a  

^a Division of Farm Animal Science   (United Kingdom)

^b VETERINARY LABORATORIES AGENCY   (United Kingdom)

^c Bristol Ctr Antimicrobial Res E   (United Kingdom)

Author keywords

Antimicrobial resistance; Growth promoters; Zoonotics

Indexed keywords

GENES; MAMMALS; SALMONELLA;

ANTIMICROBIAL RESISTANCES; CAMPYLOBACTERS; E. COLI; ENTERIC BACTERIA; GROWTH PROMOTERS; POST TREATMENT; RESISTANCE GENES; S. TYPHIMURIUM; SALMONELLA TYPHIMURIUM; ZOONOTIC;

ESCHERICHIA COLI;

AMPICILLIN; ANTIBIOTIC AGENT; AVILAMYCIN; CHLORAMPHENICOL; FURAZOLIDONE; GROWTH PROMOTOR; STREPTOMYCIN; SULFONAMIDE; TETRACYCLINE;

ANTIBIOTICS; BACTERIUM; DRUG RESISTANCE;

ANIMAL EXPERIMENT; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL COUNT; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIUM CONTAMINATION; BACTERIUM DETECTION; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; BACTERIUM ISOLATION; CAMPYLOBACTER; CONTROLLED STUDY; DRUG EFFECT; DRUG FECES LEVEL; DRUG UTILIZATION; DRUG WITHDRAWAL; EMTA GENE; ENTEROBACTERIACEAE; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; INOCULATION; INTESTINE FLORA; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; POLYMERASE CHAIN REACTION; SALMONELLA TYPHIMURIUM; SWINE; TETB GENE;

CAMPYLOBACTER; ENTERIC BACTERIA; ESCHERICHIA COLI; SALMONELLA TYPHIMURIUM; SUS SCROFA; TYPHIMURIUM;

EID: 14844298755     PISSN: 13645072     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2672.2004.02461.x     Document Type: Article

References (34)

1. Aarestrup, F.M. (1998) Association between decreased susceptibility to a new antibiotic for treatment of human diseases, everninomycin, and resistance to an antibiotic used for growth promotion in animals, avilamycin. Microbial Drug Resistance-Mechanisms Epidemiology and Disease 4, 137-141.
2. Aarestrup, P.M. and Jensen, L.B. (2000) Presence of variations in ribosomal protein L16 corresponding to susceptibility of enterococci to oligosaccharides (avilamycin and evernimicin). Antimicrobial Agents and Chemotherapy 44, 3425-3427.
3. Aarestrup, P.M. and McNicholas, P.M. (2002) Incidence of high level evernimicin resistance in Enterococcus faecium among food animals and humans. Antimicrobial Agents and Chemotherapy 46, 3088-3090.
4. Aarestrup, P.M., Agerso, Y., Gerner-Smidt, P., Madsen, M. and Jensen, L.B. (2000a) Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecalis and Enterococcus faecium from humans in the community, broilers and pigs in Denmark. Diagnostic Microbiology and Infectious Disease 37, 127-137.
5. Aarestrup, P.M., Kruse, H., Tast, E., Hammerum, A.M. and Jensen, L.B. (2000b) Associations between the use of antimicrobial agents for growth promotion and the occurrence of resistance among Enterococcus faecium from broilers and pigs in Denmark, Finland and Norway. Microbial Drug Resistance 6, 63-70.
6. Bager, F., Madsen, M., Christensen, J. and Aarestrup, P.M. (1997) Avoparcin used as a growth promoter is associated with the occurrence of vancomycin-resistant Enterococcus faecium on Danish poultry and in pig farms. Preventative Veterinary Medicine 31, 95-112.
7. Blake, D.P., Humphry, R.W., Scott, K.P., Hillman, K., Fenlon, D.R. and Low, J.C. (2003) Influence of tetracycline exposure on tetracycline resistance and the carriage of tetracycline resistance genes within commensal Escherichia coli populations. Journal of Applied Microbiology 94, 1087-1097.
8. van den Bogaard, A.E., Bruinsma, N. and Stobberingh, E.E. (2000) The effect of banning avoparcin on VRE carriage in the Netherlands. Journal of Antimicrobial Chemotherapy 46, 146-147.
9. Casewell, M., Friis, C, Marco, E., McMullin, P. and Phillips, I. (2003) The European ban on growth-promoting antibiotics and emerging consequences for human and animal health. Journal of Antimicrobial Chemotherapy 52, 159-161.
10. Corpet, D.E. (2000) Mechanism of antimicrobial growth promoters used in animal feed. Revue de Medecine Veterinaire 151, 99-104.
11. Danish Integrated Antimicrobial Resistance Monitoring and Research Programme (2002) DANMAP 2001 - Use of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Bacteria from Food Animals, Food and Humans in Denmark. Copenhagen, Denmark: Danish Veterinary Laboratory.
12. Davies, R. and Roberts, T.A. (1999) Antimicrobial susceptibility of enterococci recovered from commercial swine carcasses: effect of feed additives. Letters in Applied Microbiology 29, 327-333.
13. Delsol, A.A., Anjum, M., Woodward, M.J., Sunderland, J. and Roe, J.M. (2003) The effect of chlortetracycline treatment and its subsequent withdrawal on multi-resistant Salmonella enterica serovar Typhimurium DT104 and commensal E. coli in the pig. Journal of Applied Microbiology 95, 1226-1234.
14. Delsol, A., Pumbwe, L., Piddock, L., Woodward, M., Sunderland, J. and Roe, J. (2004a) Emergence of fluoroquinolone resistance in the native Campylobacter population of pigs exposed to enrofloxacin. Journal of Antimicrobial Chemotherapy 53, 872-874.
15. Delsol, A., Woodward, M.J. and Roe, J.M. (2004b) Effect of a 5-day enrofloxacin treatment on Salmonella enterica serotype Typhimurium DT104 in the pig. Journal of Antimicrobial Chemotherapy 53, 396-398.
16. Dutka-Malen, S., Evers, S. and Courvalin, P. (1995) Detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant Enterococci by PCR. Journal of Clinical Microbiology 33, 24-27.
17. Evans, M.C. and Weneger, H.C. (2003) Antimicrobial growth promoters and Salmonella spp., Campylobacter spp. in poultry and Swine, Denmark. Emerging Infectious Diseases 9, 489-491.
18. Gambarotto, K., Ploy, M.C., Dupron, F., Giangiobbe, M. and Denis, F. (2001) Occurrence of vancomycin-resistant enterococci in pork and poultry products from a cattle-rearing area of France. Journal of Clinical Microbiology 39, 2354-2355.
19. Goosens, H. (1998) Spread of vancomycin-resistant enterococci: differences between the United States and Europe. Infection Control and Hospital Epidemiology 19, 546-551.
20. Jensen, B.B. (1998) The impact of feed additives on the microbial ecology of young pigs. Journal of Animal and Feed Science 7, 45-64.
21. Kropec, A., Frank, U., Jonas, D., Thriene, W., Schmidt-Eisenlohr, E. and Daschner, F.D. (2001) In vitro susceptibility to everninomycin of gram-positive nosocomial pathogens isolated from intensive care units in Germany. Chemotherapy 47, 15-18.
22. Liebana, E., Gibbs, M., Clouting, C., Barker, L., Clifton-Hadley, F.A., Pleydell, E., Abdalhamid, B., Hanson, N.D. et al. (2004) Characterisation of beta-lactamases responsible for resistance to extended-spectrum cephalosporins in Escherichia coli and Salmonella enterica strains from food producing animals in the United Kingdom. Microbial Drug Resistance 10, 1-9.
23. MAFF (1998) A Review of Antimicrobial Resistance in the Food Chain: a Technical Report for MAFF, London, UK: MAFF.
24. Magnussen, J.D., Dalidowicz, J.E., Thomson, T.D. and Donoho, A.L. (1991) Tissue residues and metabolism of avilamycin in swine and rats. Journal of Agricultural Food Chemistry 39, 306-310.
25. Mann, P., Xiong, L., Mankin, A., Chau, A., Mendrick, C., Najarian, D., Cramer, C., Loebenberg, D. et al. (2001) EmtA, a rRNA methyltranferase conferring high-level evernimicin resistance. Molecular Microbiology 41, 1349-1356.
26. Ministry of Food (2001) Annual Report on Zoonoses in Denmark 2000. Copenhagen, Denmark: Danish Veterinary Laboratory.
27. Randall, L.P., Cooles, S.W., Saver, A.R. and Woodward, M.J. (2001) Cyclohexane resistance in Salmonella of different serovars is associated with increased resistance to multiple antibiotics, disinfectants and dyes. Journal of Medical Microbiology 50, 1-6.
28. Randall, L.P., Cooles, S.W., Osborn, M.K., Piddock, L.J.V. and Woodward, M.J. (2004) Antibiotic resistance genes, integrons and multiple antibiotic resistance in 35 serotypes of Salmonella enterica isolated from humans and animals in the UK. Journal of Antimicrobial Chemotherapy 53, 208-216.
29. Robredo, B., Singh, K.V., Baquero, F., Murray, B.E. and Torres, C. (2000) Vancomycin-resistant enterococci isolated from animals and food. International Journal of Food Microbiology 54, 197-204.
30. Skirrow, M.B. (1990) Foodborne illness. Campylobacter. Lancet 336, 921-923.
31. Sunderland, J., Lovering, A.M., Tobin, C.M., MacGowan, A.P., Roe, J.M. and Delsol, A.A. (2004) Determination of avilamycin in pig faeces by high performance liquid chromatography. International Journal of Antimicrobial Agents, 24, 511-514.
32. Ungemach, F.R. (2000) Figures on quantities of antibacterials used for different purposes in the EU-countries and interpretation. Acta Veterinaria Scandinavica 93, 89-98.
33. Wegener, U.C., Madsen, M., Nielsen, P. and Aarestrup, F.M. (1997) Isolation of vancomycin-resistant Enterococcus faecium from food. International Journal of Food Microbiology 35, 57-66.
34. White, D.G., Goldman, J.D., Demple, B. and Levy, S.B. (1997) Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli. Journal of Bacteriology 179, 6122-6129.