Stimulation of isolated ventricular myocytes within an open architecture microarray

IEEE Transactions on Biomedical Engineering

Volumn 52, Issue 3, 2005, Pages 531-538

  Klauke, Norbert ^a   Smith, Godfrey L ^b   Cooper, Jonathan M ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Electric field; Electrodes; Imaging; Multiplexing; Muscle

Indexed keywords

BIOLOGICAL ORGANS; CARDIOLOGY; CELLS; ELASTOMERS; GOLD; MICROELECTRODES; PHOTOLITHOGRAPHY; PHYSIOLOGY; SILICON;

INTEGRATED MICROELECTRODES; MICROFLUIDIC CHAMBERS; PHYSIOLOGICAL RESPONSE; VENTRICULAR MYOCYTES;

BIOMEDICAL ENGINEERING;

CALCIUM ION; DIMETICONE; DYE; SILASTIC;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL ISOLATION; CONTROLLED STUDY; DRUG DETERMINATION; ELECTRIC CURRENT; ELECTRIC FIELD; ELECTROSTIMULATION; EXCITATION CONTRACTION COUPLING; HEART LEFT VENTRICLE; HEART MUSCLE CELL; IMAGING; MICROELECTRODE; MICROFLUIDICS; MICROPIPETTE; MICROSCOPE; MUSCLE FIBER CONTRACTION; NONHUMAN; RABBIT;

ACTION POTENTIALS; ANIMALS; CALCIUM; CELL CULTURE TECHNIQUES; CELLS, CULTURED; ELECTRIC STIMULATION; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FLOW CYTOMETRY; HEART VENTRICLES; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROSCOPY, FLUORESCENCE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; RABBITS;

EID: 14844286513     PISSN: 00189294     EISSN: None     Source Type: Journal    
DOI: 10.1109/TBME.2004.842971     Document Type: Article

References (28)

1. I. Cavero, M. Mestre, J. M. Guillon, and W. Crumb, "Drugs that prolong QT intervals as an unwanted effect: Assessing their likelihood of inducing hazardous cardiac dysrhythmias," Expert Opin. Pharmacotherapy, vol. 1, pp. 947-973, 2000.
2. J. F. Worley and M. J. Main, "An industrial perspective on utilizing functional ion channel assays for high throughput screening," Receptors Channels, vol. 8, pp. 269-282, 2002.
3. M. P. Maher and J. E. Gonzalez, "Ion channel functional analysis using electrical stimulation," in Soc. Neurosci., Meeting Abstr., vol. 26, 2000, p. 1906.
4. D. M. Bers, Excitation-Contraction Coupling and Cardiac Contractile Force. Dordrecht, The Netherlands: Kluwer, 2001.
5. M. T. Keating and M. C. Sanguinetti, "Molecular and cellular mechanisms of cardiac arrhythmias," Cell, vol. 104, pp. 569-580, 2001.
6. J. Tygat, "How to isolate cardiac myocytes," Cardiovasc. Res., vol. 28, pp. 280-283, 1994.
7. i transients in adult rat myocytes," Am. J. Physiol. (Heart Circ. Physiol.), vol. 283, pp. H576-H583, 2002.
8. A. Stett, V. Bucher, C. Burkhardt, U. Weber, and W. Nisch, "Patch-clamping of primary cardiac cells with micro-openings in polyimide films," Med. Biol. Eng. Comput., vol. 41, pp. 233-240, 2003.
9. H.R. Lu, E. Vlaminckx, K. Van Ammel, and F. De Clerck, "Drug-induced long QT in isolated rabbit Purkinje fibers: Importance of action potential duration, triangulation and early afterdepolarizations," Eur. J. Pharmacol., vol. 452, pp. 183-192, 2002.
10. 2+ influx," J. Neurochem., vol. 74, pp. 1443-1451, 2000.
11. M. Falconer, F. Smith, S. Surah-Narwal, G. Congrave, Z. Liu, P. Hayter, G. Ciaramella, W. Keighley, P. Haddock, G. Waldron, and A. Sewing, "2002. High-throughput screening for ion channel modulators," J. Biomolecular Screening, vol. 7, pp. 460-465, 2002.
12. L. M. Hondeghem, L. Carlsson, and G. Duker, "Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic," Cumulation, vol. 103, pp. 2004-2013, 2001.
13. P. C. H. Li, W. J. Wang, and M. Parameswaran, "An acoustic wave sensor incorporated with a microfluidic chip for analyzing muscle cell contraction," Analyst, vol. 128, pp. 225-231, 2003.
14. J. Farinas, A. W. Chow, and H. G. Waga, "A microfluidic device for measuring cellular membrane potential," Analytical Biochem., vol. 295, pp. 138-142, 2001.
15. A. J. Bard and L. R. Faulkner, Electrochemical Methods: Fundamentals and Applications. New York: Wiley, 2001.
16. N. Klauke, G. L. Smith, and J. M. Cooper, "Stimulation of single isolated adult ventricular myocytes within a low volume using a planar microelectrode array," Biophys. J., vol. 85, pp. 1766-1774, 2003.
17. D. A. Eisner, C. G. Nichols, S. C. O'Neill, G. L. Smith, and M. Valdeomillos, "The effects of metabolic inhibition on intracellular calcium an pH in isolated rat ventricular cells," J. Physiol., vol. 411, pp. 393-418, 1989.
18. J. I. Jones, R. E. Jones, and G. Balasky, "Improved cardiac cell excitation with symmetrical biphasic defibrillator waveforms," Am. J. Physiol. 253 (Heart Circ. Physiol.22), vol. 253, pp. HI418-HI424, 1987.
19. P. M. Dentinger, K. L. Krafcik, K. L. Simison, R. P. Janek, and J. Hachman, "High aspect ratio patterning with a proximity ultraviolet source," Microelectron. Eng., vol. 61, pp. 1001-1007, 2002.
20. C. G. Guymon, M. L. Hunsaker, J. N. Harb, D. Henderson, and R. L. Rowley, "Effects of solvent model flexibility on aqueous electrolyte behavior between electrodes," J. Chem. Phys., vol. 118, pp. 10 195-10 202, 2003.
21. Y. M. Song and R. Ochi, "Hyperpolarization and lysophosphatidylcholine induce inward currents and ethidium fluorescence in rabbit ventricular myocytes," J. Physiol., vol. 545, pp. 463-473, 2002.
22. I. R. Efimov, D. T. Huang, J. M. Rendt, and G. Salama, "Optical mapping of repolarization and refractoriness from intact hearts," Circulation, vol. 90, pp. 1469-1480, 1994.
23. E. Klusmann and J. W. Schulze, "pH-microscopy-theoretical and experimental investigations," Electrochimica Acta. vol. 42, pp. 3123-3134, 1997.
24. E. Carmeliet, "Cardiac ionic currents and acute ischemia: From channels to arrhythmias," Physiological Rev., vol. 79, pp. 917-1017, 1999.
25. K. W. Spitzer, P. R. Ershler, R. L. Skolmick, and R. D. Vaughan-Jones, "Generation of intracellular pH gradients in single cardiac myocytes with a microperfusion system," Am. J. Physiol. Heart Circ. Physiol., vol. 278, pp. H1371-H1382, 2000.
26. D. G. Allen and X.-H. Xiao, "Role of the cardiac Na+/H+ exchanger during ischemia and reperfusion," Cardiovasc. Res., vol. 57, pp. 934-941, 2003.
27. 2+ in left ventricular myocyte sub-types from rabbits with heart failure," Cardiovasc. Res., vol. 45, pp. 397-409, 2000.
28. V. G. Fast and R. E. Ideker, "Simultaneous optical mapping of transmembrane potential and intracellular calcium in myocyte cultures," J. Cardiovasc. Electrophysiol., vol. 11, pp. 547-556, 2000.