Survival versus neglect: Redefining thymocyte subsets based on expression on NKG2D ligand(s) and MHC class I

European Journal of Immunology

Volumn 35, Issue 2, 2005, Pages 439-448

  Li, Jennifer ^b,c   Rabinovich, Brian A ^d   Hurren, Rose ^c   Cosman, David ^d   Miller, Richard G ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d AMGEN INC   (United States)

Author keywords

Apoptosis; NK cells; Thymus

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2D; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; BONE MARROW TRANSPLANTATION; CELL DEATH; CELL MATURATION; CELL SELECTION; CELL SUBPOPULATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; IRRADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYMOCYTE;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BIOLOGICAL MARKERS; CASPASES; DOWN-REGULATION; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS I; LIGANDS; MICE; MICE, INBRED BALB C; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TIME FACTORS;

EID: 14744301088     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425621     Document Type: Article

References (41)

1. Egerton, M., Scollay, R. and Shortman, K., Kinetics of mature T cell development in the thymus. Proc. Natl. Acad. Sci. USA 1990. 87: 2579-2582.
2. Dokun, A. O., Chu, D. T., Yang, L., Bendelac, A. S. and Yokoyama, W. M., Analysis of in situ NK cell responses during viral infection. J. Immunol. 2001. 167: 5286-5293.
3. von Boehmer, H., Aifantis, I., Gounari, F., Azogui, O., Haughn, L., Apostolou, I., Jaeckel, E., Grassi, F. and Klein, L., Thymic selection revisited: how essential is it? Immunol. Rev. 2003. 191: 62-78.
4. Singer, A., New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision. Curr. Opin. Immunol. 2002. 14: 207-215.
5. Surh, C. D. and Sprent, J., T cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 1994. 372: 100-103.
6. Lucas, B., Vasseur, F. and Penit, C., Normal sequence of phenotypic transitions in one cohort of 5-bromo-2′-deoxyuridine-pulse-labeled thymocytes. Correlation with T cell receptor expression. J. Immunol. 1993. 151: 4574-4582.
7. Diefenbach, A., Jamieson, A. M., Liu, S. D., Shastri, N. and Raulet, D. H., Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 2000. 1: 119-126.
8. Hansson, M., Kiessling, R., Andersson, B., Karre, K. and Roder, J., NK cell-sensitive T cell subpopulation in thymus: inverse correlation to host NK activity. Nature 1979. 278: 174-176.
9. Hansson, M., Karre, K., Kiessling, R., Roder, J., Andersson, B. and Hayry, P., Natural NK-cell targets in the mouse thymus: characteristics of the sensitive cell population. J. Immunol. 1979. 123: 765-771.
10. Rabinovich, B. A., Li, J., Shannon, J., Hurren, R., Chalupny, J., Cosman, D. and Miller, R. G., Activated but not resting T cells can be recognized and killed by syngeneic natural killer cells. J. Immunol. 2003. 170: 3572-3576.
11. Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L. and Spies, T., Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999. 285: 727-729.
12. Cosman, D., Mullberg, J., Sutherland, C. L., Chin, W., Armitage, R., Fanslow, W., Kubin, M. and Chalupny, N. J., ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 2001. 14: 123-133.
13. Cerwenka, A., Bakker, A. B., McClanahan, T., Wagner, J., Wu, J., Phillips, J. H. and Lanier, L. L., Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity 2000. 12: 721-727.
14. Carayannopoulos, L. N., Naidenko, O. V., Fremont, D. H. and Yokoyama, W. M., Cutting edge: Murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D. J. Immunol. 2002. 169: 4079-4083.
15. Ceredig, R. and Rolink, T., A positive look at double-negative thymocytes. Nat. Rev. Immunol. 2002. 2: 888-897.
16. Sprent, J. and Kishimoto, H., The thymus and central tolerance. Transplantation 2001. 72: S25-28.
17. Kaufmann, S. H. and Hengartner, M. O., Programmed cell death: alive and well in the new millennium. Trends Cell Biol. 2001. 11: 526-534.
18. Zimmermann, K. C., Bonzon, C. and Green, D. R., The machinery of programmed cell death. Pharmacol. Ther. 2001. 92: 57-70.
19. Stennicke, H. R. and Salvesen, G. S., Caspases - controlling intracellular signals by protease zymogen activation. Biochim. Biophys. Acta 2000. 1477: 299-306.
20. Marchetti, M. C., Di Marco, B., Cifone, G., Migliorati, G. and Riccardi, C., Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation. Blood 2003. 101: 585-593.
21. Zhang, J., Mikecz, K., Finnegan, A. and Glant, T. T., Spontaneous thymocyte apoptosis is regulated by a mitochondrion-mediated signaling pathway. J. Immunol. 2000. 165: 2970-2974.
22. Doerfler, P., Forbush, K. A. and Perlmutter, R. M., Caspase enzyme activity is not essential for apoptosis during thymocyte development. J. Immunol. 2000. 164: 4071-4079.
23. Hough, M., Takei, F., Humphries, R. and Kay, R., Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen. J. Exp. Med. 1994. 179: 177-184.
24. - thymocytes are functionally immature. J. Immunol. 1991. 147: 1779-1785.
25. Nikolic-Zugic, J. and Bevan, M. J., Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus. Int. Immunol. 1990. 2: 135-141.
26. Richie, E. R., McEntire, B., Crispe, N., Kimura, J., Lanier, L. L. and Allison, J. P., Alpha/beta T cell antigen receptor gene and protein expression occurs at early stages of thymocyte differentiation. Proc. Natl. Acad. Sci. USA 1988. 85: 1174-1178.
27. Crispe, I. N., Shimonkevitz, R. P., Husmann, L. A., Kimura, J. and Allison, J. P., Expression of T cell antigen receptor beta-chains on subsets of mouse thymocytes. Analysis by three-color flow cytometry. J. Immunol. 1987. 139: 3585-3589.
28. Born, W., McDuffie, M., Roehm, N., Kushnir, E., White, J., Thorpe, D., Stefano, J., Kappler, J. and Marrack, P., Expression and role of the T cell receptor in early thymocyte differentiation in vitro. J. Immunol. 1987. 138: 999-1008.
29. Hare, K. J., Jenkinson, E. J. and Anderson, G., CD69 expression discriminates MHC-dependent and -independent stages of thymocyte positive selection. J. Immunol. 1999. 162: 3978-3983.
30. Peterson, D. A., DiPaolo, R. J., Kanagawa, O. and Unanue, E. R., Cutting edge: Negative selection of immature thymocytes by a few peptide-MHC complexes: differential sensitivity of immature and mature T cells. J. Immunol. 1999. 162: 3117-3120.
31. Brandle, D., Muller, S., Muller, C., Hengartner, H. and Pircher, H., Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection. Eur. J. Immunol. 1994. 24: 145-151.
32. + thymocytes. Eur. J. Immunol. 1993. 23: 739-746.
33. Yamashita, I., Nagata, T., Tada, T. and Nakayama, T., CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection. Int. Immunol. 1993. 5: 1139-1150.
34. Le Campion, A., Vasseur, F. and Penit, C., Regulation and kinetics of premigrant thymocyte expansion. Eur. J. Immunol. 2000. 30: 738-746.
35. Ernst, B., Surh, C. and Sprent, J., Thymic selection and cell division. J. Exp. Med. 1995. 182: 961-971.
36. Scollay, R. and Godfrey, D. I., Thymic emigration: conveyor belts or lucky dips? Immunol. Today 1995. 16: 268-273; discussion 273-264.
37. Hess, K. L., Johnson, J. D. and Cook-Mills, J. M., Different orders for acquisition of apoptotic characteristics by leukocytes. J. Leukoc. Biol. 2001. 70: 405-412.
38. + precursors. Proc. Natl. Acad. Sci. USA 1989. 86: 7542-7546.
39. Jamieson, A. M., Diefenbach, A., McMahon, C. W., Xiong, N., Carlyle, J. R. and Raulet, D. H., The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity 2002. 17: 19-29.
40. Groh, V., Rhinehart, R., Randolph-Habecker, J., Topp, M. S., Riddell, S. R. and Spies, T., Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2001. 2: 255-260.
41. Hammond, K. J., Pelikan, S. B., Crowe, N. Y., Randle-Barrett, E., Nakayama, T., Taniguchi, M., Smyth, M. J., van Driel, I. R., Scollay, R., Baxter, A. G. and Godfrey, D. I., NKT cells are phenotypically and functionally diverse. Eur. J. Immunol. 1999. 29: 3768-3781.