Hand transplantation: A future clinical option?

Acta Orthopaedica Scandinavica

Volumn 76, Issue 1, 2005, Pages 14-27

  Kvernmo, Hebe D ^a   Gorantla, Vijay S ^b   Gonzalez, Ruben N ^b   Breidenbach III, Warren C ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b CHRISTINE M KLEINERT INSTITUTE FOR HAND AND MICROSURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CALCINEURIN INHIBITOR; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIBODY; MERCAPTOPURINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS; CYCLOSPORIN A;

ALLOTRANSPLANTATION; CLINICAL ARTICLE; ETHICS; FUNCTIONAL ASSESSMENT; HAND SURGERY; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; LIMB BLOOD FLOW; REVIEW; TRANSPLANTATION; VASCULARIZATION; ARM; ARTICLE; CLINICAL PROTOCOL; COMPOSITE GRAFT; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HISTOPATHOLOGY;

ETHICS, MEDICAL; HAND; HUMANS; IMMUNOSUPPRESSIVE AGENTS; REPLANTATION; TRANSPLANTATION IMMUNOLOGY; TREATMENT OUTCOME;

EID: 14744300095     PISSN: 00016470     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016470510030283     Document Type: Review

References (117)

1. Allison A C, Eugui E M. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol Rev 1993; 136: 5-28.
2. Altman L K. A short, speckled history of a transplanted hand. NY Times (Print) 2001; Febr 27: F1,F2.
3. Armitage J M, Kormos R L, Griffith B P, Hardesty R L, Fricker F J, Stuart R S, Marrone G C, Todo S, Fung J, Starzl T E. A clinical trial of FK 506 as primary and rescue immunosuppression in cardiac transplantation. Transpl Proc 1991; 23 (1): 1149-52.
4. Bachman D, Burloux G. The psychiatrist and the hand transplant. In: Composite Tissue Allografts (ed. Dubernard J-M). Paris: John Libbey Eurotext, 2001: 85-91.
5. Barker J H, Jones Jr J W, Breidenbach III W C. Closing remarks. Proceedings of the International Symposium on Composite Tissue Allotransplantation, Louisville, Kentucky. Transplant Proc (Special Issue) 1998; 30: 2787.
6. Barker J H, Breidenbach III W C, Hewitt C W. Second International Symposium on Composite Tissue Allotransplantation. Introduction. Microsurgery (Special Issue) 2000; 20 (8): 359.
7. Barnard C N. A human cardiac transplant: An interim report of a successful operation performed at Groote Schuur Hospital, Cape Town. S A Med J 1967; (37): 1271-4.
8. BBC News. Tongue transplant patient doing well. July 22, 2003: http://news.bbc.co.uk/1/hi/health/3086509.stm
9. Benhaim P, Anthony J P, Ferreira L, Borsanyi J-P, Mathes S J. Use of combination of low-dose cyclosporine and RS-61443 in a rat hindlimb model of composite tissue allotransplantation. Transplantation 1996; 61 (4): 527-32.
10. Birchall M. Tongue transplantation. Lancet 2004; 363 (9422): 1663.
11. Black K S, Hewitt C W. Report: Composite tissue transplantation workshop. Washington, D.C.: Department of Veterans Affairs, Rehabilitation Research and Development Service; 1991.
12. Borel J F, Kis Z L. The discovery and development of cyclosporine (Sandimmune). Transplant Proc 1991; 23 (2): 1867-74.
13. Breidenbach III W C, Tobin II G R, Gorantla V S, Gonzales R N, Granger D K. A position statement in support of hand transplantation. J Hand Surg (Am) 2002; 27 (5): 760-70.
14. Brenner M J, Tung T H, Jensen J N, Mackinnon S E. The spectrum of complications of immunosuppression: is the time right for hand transplantation? J Bone Joint Surg (Am) 2002; 84 (10): 1861-70.
15. Carpenter J P, Tomaszewski J E. Immunosuppression for human saphenous vein allograft bypass surgery: A prospective randomized trial. J Vasc Surg 1997; 26 (1): 32-42.
16. Carrel A. Results of the transplantation of blood vessels, organs and limbs. JAMA 1908; 51: 1662-7.
17. Carroll D. A quantitative test of upper extremity function. J Chronic Dis 1965; 18: 479-91.
18. Cooney W, Hentz V R. Position statement: Council of the American Society for Surgery of the Hand. Hand transplantation-primum non nocere. J Hand Surg (Am) 2002; 27(1): 165-8.
19. Danilevicius Z. SS Cosmas and Damian. The patron saints of medicine in art. JAMA 1967; 201 (13): 1021-5.
20. Da Varagine J. Leggenda Aurea. Florence, Italy: Libreria Editrice Fiorentina 1952: 648-52.
21. Derom F, Barbier F, Ringoir S, Versieck J, Roily G, Berzsenyi G, Vermeire P, Vrints L. Ten-month survival after lung homotransplantation in man. Thoracic Cardiovasc Surg 1971; 61 (6): 835-46.
22. Doolabh V B, Mackinnon S E. FK506 accelerates functional recovery following nerve grafting in a rat model. Plast Reconstr Surg 1999; 103 (7): 1928-36.
23. Dubernard J-M, Owen E, Herzberg G, Lanzettà M, Martin X, Kapila H, Dawahra M, Hakim N S. Human hand allograft: report on first 6 months. Lancet 1999, 353 (9161): 1315-20.
24. Duquesnoy R J. Is histocompatibility testing needed for composite tissue transplantation? Transpl Proc 1998; 30: 2724-8.
25. Edgell S E, McCabe S J, Breidenbach III W C, Neace W P, LaJoie A S, Abell T D. Different reference frames can lead to different hand transplantation decisions by patients and physicians. J Hand Surg (Am) 2001; 26 (2): 196-200.
26. Ferrara J L M, Deeg H J. Graft-versus-host disease. N Engl J Med 1991; 324 (10): 667-74.
27. First M R, Peddi V R. Malignancies complicating organ transplantation. Transpl Proc 1998; 30: 2768-70.
28. Fishman J A, Rubin R H. Infection in organ-transplant recipients. N Engl J Med 1998; 338 (24): 1741-51.
29. Foucher G. Prospects for hand transplantation. Lancet 1999; 353: 1286-7.
30. Francois C G, Breidenbach III W C, Maldonado C, Kakoulidis T P, Hodges A, Dubernard J-M, Owen E, Pei G, Ren X, Barker J H. Hand transplantation: comparisons and observations of the first four clinical cases. Microsurgery 2000; 20: 360-71.
31. Friend P J, Waldmann H, Hale G, Cobbold S, Rebello P, Thiru S, Jamieson N V, Johnston P S, Calne R Y. Reversal of allograft rejection using the monoclonal antibody, Campath-1G. Transplant Proc 1991; 23 (4): 2253-4.
32. Fung J J, Todo S, Jain A, McCauley J, Alessiani M, Scotti C, Starzl T E. Conversion from cyclosporine to FK 506 in liver allograft recipients with cyclosporine-related complications. Transpl Proc (Suppl 1) 1990; 22 (1): 6-12.
33. Giraux P, Sirigu A, Schneider F, Dubernard J M. Cortical reorganization in motor cortex after graft of both hands. Nat Neurosci 2001, 4 (7): 691-2.
34. Gorantla V S, Barker J H, Jones Jr J W, Prabhune K, Maldonado C, Granger D K. Immunosuppressive agents in transplantation: mechanisms of action and current anti-rejection strategies. Microsurgery 2000; 20 (8): 420-9.
35. Goto T, Kino T, Hatanaka H, Nishiyama M, Okuhara M, Kohsaka M, Aoki H, Imanaka H. Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces Tsukubaensis. Transplant Proc (Suppl 6) 1987; 19 (5): 4-8.
36. Goulet O, Revillon Y, Brousse N, Jan D, Canion D, Rambaud C, Cerf-Bensussan N, Buisson C, Hubert P, de Potter S, Mougenot J-F, Fischer A, Ricour C. Successful small bowel transplantation in an infant. Transplantation 1992; 53 (4): 940-3.
37. Graham B, Adkins P, Tsai T-M, Firrell J, Breidenbach III W C. Major replantation versus revision amputation and prosthetic fitting in the upper extremity: a late functional outcomes study. J Hand Surg (Am) 1998; 23 (5): 783-91.
38. Granger D K, Breidenbach III W C, Pidwell D J, Jones J W, Baxter-Lowe L A, Kaufmann C L. Lack of donor hyporesponsiveness and donor chimerism after clinical transplantation of the hand. Transplantation 2002; 74 (11): 1624-30.
39. Guimberteau J-C. Ten years follow-up of two cases of vascularized digital flexor system allotransplants. In: Composite tissue allografts (ed. Dubernard J-M). Paris: John Libbey Eurotext, 2001: 41-2.
40. Guimberteau J-C, Baudet J, Panconi B, Boileau R, Potaux L. Human allotransplant of a digital flexion system vascularized on the ulnar pedicle: a preliminary report and 1-year follow-up of two cases. Plast Reconstr Surg 1992; 89: 1135-47.
41. Guoxian P, Liqiang G, Lixin Y. Long-term follow-up ol hand allografts. Abstract. J Reconstr Microsurg 2004 20 (1): 111.
42. Herndon J H. Composite-tissue transplantation - A new frontier. N Engl J Med 2000; 343 (7): 503-5.
43. Hettiaratchy S, Butler P E, Lee WPA. Lessons from hand transplantations. Lancet 2001; 357 (9255): 494-5.
44. Hettiaratchy S, Randolph M A, Lee WPA. Long-term consideration of hand transplantation. Transplantation 2003; 75 (9): 1605.
45. Hofmann G O, Kirschner M H. Allogeneic vascularized bone and joint transplantation. First five years experience. In: Composite tissue allografts (ed. Dubernard J-M). Paris: John Libbey Eurotext, 2001: 43-7.
46. Hofmann O G, Kirschner M H, Bühren V, Land W. Allogenic vascularized transplantation of a human femoral diaphysis under cyclosporin A immunosuppression. Transpl Int 1995; 8 (5): 418-9.
47. Hofmann G O, Kirschner M H, Wagner F D, Brauns L, Gonschorek O, Bühren V. Allogeneic vascularized grafting of human knee joints under postoperative immunosuppression of the recipient. World J Surg 1998; 22: 818-23.
48. Jones Jr J W, Üstüner E T, Zdichavsky M., Edelstein J, Ren X, Maldonado C, Ray M, Jevans A W, Breidenbach III W C, Gruber S A, Barker J H, for The Louisville Hand Transplant Team. Long-term survival of an extremity composite tissue allograft with FK506-mycophenolate mofetil therapy. Surgery 1999; 126 (2): 384-8.
49. Jones Jr J W, Gruber S A, Barker J H, Breidenbach III W C. Successful hand transplantation. One-year follow-up. N Engl J Med 2000; 343 (7): 468-73.
50. Jones N F. Concerns about human hand transplantation in the 21st century. Debate. J Hand Surg (Am) 2002; 27 (5): 771-87.
51. Jones T R, Humphrey P A, Brennan D C. Transplantation of vascularized allogeneic skeletal muscle for scalp reconstruction in renal transplant patient. Transplant Proc 1998; 30 (6): 2746-53.
52. Judet H. Essai sur la greffe des tissus articulaires. C R Acad Sci 1908; 146: 193-6.
53. Kahan B D. Cosmas and Damian revisited. Transplant Proc (Suppl 1) 1983; 15 (4): 2211-6.
54. Kahan B D, Podbielski J, Napoli K L, Katz S M, Meier-Kriesche H-U, Van Buren C T. Immunosuppressive effects and safety of a sirolimus/cyclosporine combination regimen for renal transplantation (Clinical Transplantation). Transplantation 1998; 66 (8): 1040-6.
55. Kirk A D, Hale D A, Mannon R B, Kleiner D E, Hoffmann S C, Kampen R L, Cendales L K, Tadaki D K, Harlan D M, Swanson S J. Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (Campath-1H) (Clinical Transplantation). Transplantation 2003; 76 (1): 120-9.
56. Lanzettà M. Indications for hand allografts. In: Composite tissue allografts (ed. Dubernard J-M). Paris: John Libbey Eurotext, 2001: 83.
57. Lanzettà M. Functional results of the italian hand transplantation program. J Hand Surg (Br) (Suppl 1) 2003; 28: 74.
58. Lee S J, Vogelsang G, Flowers M E D. Chronic graft-versus-host disease. BB&MT 2003; 9: 215-33.
59. Lee W P A. The debate over hand transplantation. J Hand Surg (Am) 2002; 27 (5): 757-9.
60. Lee W P A, Mathes D W. Hand transplantation: pertinent data and future outlook. J Hand Surg (Am) 1999; 24 (5): 906-13.
61. Lee W P A, Yaremchuk M J, Pan Y-C, Randolph M A, Tan C M, Weiland A J. Relative antigenicity of components of a vascularized limb allograft. Plast Reconstr Surg 1991; 87 (3): 401-11.
62. Leendert C P, de Fijter J W, Sijpkens Y W J. Chronic renal transplant rejection. In: Kidney Transplantation. Principles and practice (ed. Morris PJ). Philadelphia: W.B. Saunders Company, 2001: 408-18.
63. Levi D M, Tzakis A G, Kato T, Madariaga J, Mittal N K, Nery J, Nishida S, Ruiz P. Transplantation of the abdominal wall. Lancet 2003; 361 (9376): 2173-6.
64. Lexer E. Substitution of whole or half joints from freshly amputated extremities by free plastic operation. Surg Gyn Obst 1908; 6: 601-7.
65. Lillehei R C, Ruix J O, Aquino C, Goetz F. Transplantation of the pancreas. Acta Endocrinol Suppl (Copenh) 1976; 205: 303-20.
66. Llull R. An open proposal for clinical composite tissue allotransplantation. Transpl Proc 1998; 30 (6): 2692-6.
67. Lubbe A S. Successful hand transplantation or too early to tell? Transplantation 2003; 75 (11): 1916-7.
68. Lundborg G. Hand transplantation. Editorial. Scand J Plast Reconstr Hand Surg 1999; 33: 369-71.
69. Mackinnon S E, Hudson A R. Clinical application of peripheral nerve transplantation. Plast Reconstr Surg 1992; 90 (4): 695-9.
70. Mackinnon S E, Doolabh V B, Novak C B, Trulock E P. Clinical outcome following nerve allograft transplantation. Plast Reconstr Surg 2001; 107 (6): 1419-29.
71. Manske P R. Hand transplantation. Editorial. J Hand Surg (Am) 2001; 26 (2): 193-5.
72. Margreiter R, Brandacher G, Ninkovic M, Steurer W, Kreczy A, Schneeberger S. A double-hand transplant can be worth the effort! Transplantation 2002; 74 (1): 85-90.
73. Mathew T H, for the Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group. A blinded, long-term, randomized multicenter study of mycophenolate mofetil in cadaveric renal transplantation: results at three years (Clinical Transplantation). Transplantation 1998; 65 (11): 1450-4.
74. McAlister V C, Gao Z, Peltekian K, Domingues J, Mahalati K, MacDonald A S. Sirolimus-tacrolimus combination immunosuppression. Lancet 2000; 355 (9201): 376-7.
75. McCabe S J, Rodocker G, Julliard K, Breidenbach III W C, Marcel C, Shirbacheh M V, Barker J. Using decision analysis to aid in the introduction of upper extremity transplantation. Transpl Proc 1998; 30: 2783-6.
76. Medawar P B. The behaviour and fate of skin autografts and skin homografts in rabbits. J Anat 1944; 78: 176-203.
77. Medical Tribune-World Wide report. Transplant is successful with a cadaver forearm. Med Trib Med News 1964; 5 (20): 1,38.
78. Merrill J P, Murray J E, Harrison J H, Guild W R. Successful homotransplantation of the human kidney between identical twins. JAMA 1956; 160 (4): 277-82.
79. Min Z, Jones N F. Limb transplantation in rats: immunosuppression with FK-506. J Hand Surg (Am) 1995; 20 (1): 77-87.
80. Moss A, Najarian J S, Sutherland D E R, Payne W D, Gruessner R W G, Humar A, Kandaswamy R, Gillingham K J, Dunn D L, Matas A J. 5,000 kidney transplants - A single-center experience. In: Clinical Transplants (eds. Cecka JM and Terasaki PI). LA, California: UCLA Immunogenetics Center, 2000: 159-71.
81. Murray J E, Merrill J P, Dammin G J, Dealy J B, Alexandre G W, Harrison J H. Kidney transplantation in modified recipients. Ann Surg 1962; 156: 337-55.
82. Murray J E, Merrill J P, Harrison J H, Wilson R E, Dammin G J. Prolonged survival of human-kidney homografts by immunosuppressive drug therapy. N Engl J Med 1963; 268 (24): 1315-23.
83. Neuberger J. Incidence, timing, and risk factors for acute and chronic rejection. Liver Transpl Surg (Suppl 1) 1999; 5 (4): 30-6.
84. Opelz G, Henderson R, for the Collaborative Transplant Study. Incidence of non-Hodgkin lymphoma in kidney and heart transplant recipients. Lancet 1993; 342 (8886-7): 1514-6.
85. Owen E, Dubernard J-M, Lanzettà M, Hakim N, Kapila H, Martin X, Noli R. What we have learnt from human hand allograft transplantation. In: Composite tissue allografts (ed. Dubernard J-M). Paris: John Libbey Eurotext, 2001: 5-6.
86. Pathmanathan V. Hand transplantation between homozygous twins. Personal communication with Breidenbach III W C June 2000.
87. Pei G, Zhu L, Gu L. The experience of three cases of human hand allografts in China. In: Composite Tissue Allografts (ed. Dubernard J-M). Paris: John Libbey Eurotext, 2001: 69-70.
88. Penn I. Posttransplant malignancies. Transpl Proc 1999; 31: 1260-2.
89. Perez-Abadia G, Laurentin-Perez L, Gorantla V S, Francois C G, Vossen M, Brouha P C R, Orhun H I, Anderson G L, Maldonado C, Pidwell D J, Breidenbach III W C, Barker J H. Low-dose immunosuppression in a rat hindlimb transplantation model. Transp Int 2003; 16 (12): 835-42.
90. Petit F, Minns A B, Dubernard J-M, Hettiaratchy S, Lee W P A. Composite tissue allotransplantation and reconstructive surgery. First clinical applications. Ann Surg 2003; 237 (1): 19-25.
91. Petruzzo P, Dubernard J-M. Hand transplantation: Lyon experience. In: Composite tissue allografts (ed. Dubernard J-M). Paris: John Libbey Eurotext, 2001: 63-7.
92. Prabhune K A, Gorantla V S, Maldonado C, Perez-Abadia G, Barker J H, Ildstad S T. Mixed allogeneic chimerism and tolerance to composite tissue allografts. Microsurgery 2000; 20 (8): 441-7.
93. Prabhune K A, Gorantla V S, Perez-Abadia G, Francois C G, Vossen M, Laurentin-Perez L A, Breidenbach III W C, Wang G G, Anderson G L, Pidwell D J, Barker J H, Maldonado C. Composite tissue allotransplantation in chimeric hosts part II. A clinically relevant protocol to induce tolerance in a rat model [Experimental transplantation]. Transplantation 2003; 76 (11): 1548-55.
94. Pubmed reference. Recipient of first tongue transplant recovering. CDS Rev 2003; 96 (7): 44.
95. Qayumi A K, Nikbakht-Sangari M N, Godin D V, English J C, Horley K J, Keown P A, Lim S P, Ansley D M, Koehle M S. The relationship of ischemia-reperfusion injury of transplanted lung and the up-regulation of major histocompatibility complex II on host peripheral lymphocytes. J Thorac Cardiovasc Surg 1998; 115 (5): 978-89.
96. Reigstad A, Hetland K R. Allotransplantasjon av hånd. Tidsskr Nor Lægeforen 2003; 7: 946.
97. Shapiro A M J, Lakey J R T, Ryan E A, Korbutt G S, Toth E, Warnock G L, Kneteman N M, Rajotte R V. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343 (4): 230-8.
98. Siegler M. Ethical issues in innovative surgery: should we attempt a cadaveric hand transplantation in a human subject? Transplant Proc 1998; 30: 2779-82.
99. Starzl T E. Anti-rejection therapy. In: Experience in renal transplantation (ed. Starzl TE). Philadelphia: W.B. Saunders Company, 1964: 130-41.
100. Starzl T E, Marchioro T L, Waddell W R. The reversal of rejection in human renal homografts with subsequent development of homograft tolerance. Surg Gyn Obst 1963; 117 (4): 385-95.
101. Starzl T E, Groth C G, Brettschneider L, Penn I, Fulginiti V A, Moon J B, Blanchard H, Martin A J, Porter K A. Orthotopic homotransplantation of the human liver. Ann Surg 1968; 168 (3): 392-413.
102. Starzl T E, Todo S, Tzakis A, Podesta L, Mieles L, Demetris A, Teperman L, Selby R, Stevenson W, Stieber A, Gordon R, Iwatsuki S. Abdominal organ cluster transplantation for the treatment of upper abdominal malignancies. Ann Surg 1989; 210 (3): 374-86.
103. Strauch B. Foreword. Proceedings of the Second International Symposium on Composite Tissue Allotransplantation, Louisville, Kentucky. Microsurgery (Special Issue) 2000; 20: 357.
104. Strickland J W. Hand transplant: technology over good sense. The Indiana Hand Center Newsletter 1999; 3: 2-4.
105. Strome M, Stein J, Esclamado R, Hicks D, Lorenz R R, Braun W, Yetman R, Eliachar I, Mayes J. Laryngeal transplantation and 40-month follow-up. N Engl J Med 2001; 344 (22): 1676-9.
106. Tagliacozzi G. De cutorum chirurgia per insitonem. Venice, Italy: University of Milan Library, 1597.
107. Thomas E D, Lochte H L, Lu W C, Ferrebee J W. Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med 1957; 257 (11): 491-6.
108. Thomas F, Ray P, Thomas J M. Immunological tolerance as an adjunct to allogeneic tissue grafting. Microsurgery 2000; 20 (8): 435-40.
109. Todo S, Fung J J, Demetris A J, Jain A, Venkataramanan R, Starzl T E. Early trials with FK 506 as primary treatment in liver transplantation. Transpl Proc (Suppl 1) 1990; 22 (1): 13-6.
110. Todo S, Tzakis A G, Abu-Elmagd K, Reyes J, Nakamura K, Casavilla A, Selby R, Nour B M, Wright H, Fung J J, Demetris A J, Van Thiel D H, Starzl T E. Intestinal transplantation in composite visceral grafts or alone. Ann Surg 1992; 216 (3): 223-34.
111. Üstüner E T, Zdichavsky M, Ren X, Edelstein J, Maldonado C, Ray M, Jevans A W, Breidenbach III W C, Gruber S A, Barker J H, Jones J W. Long-term composite tissue allograft survival in a porcine model with cyclosporine/ mycophenolate mofetil therapy. Transplantation 1998; 66 (12): 1581-7.
112. Üstüner E T, Majzoub R K, Ren X, Edelstein J, Maldonado C, Perez-Abadia G, Breidenbach III W C, Barker J H. Swine composite tissue allotransplant model for preclinical hand transplant studies. Microsurgery 2000; 20: 400-6.
113. Vallet B, Parmentier H, Lagouy V, Dziesmiazkiewiez N. Bilateral hand transplant: functional results after 18 months. In: Composite tissue allografts (ed. Dubernard J-M). Paris: John Libbey Eurotext, 2001: 75-6.
114. VanBuskirk A M, Pidwell D J, Adams P W, Orosz C G. Transplantation immunology. JAMA 1997; 278 (22): 1993-9.
115. Vézina C, Kudelski A, Sehgal S N. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 1975; 28 (10): 721-6.
116. Vincenti F. New monoclonal antibodies in renal transplantation. Minerva Urol Nefrol 2003; 55 (1): 57-66.
117. Wendt J R, Ulich T R, Ruzics E P, Hosteller J R. Indefinite survival of human skin allografts in patients with long-term immunosuppression. Ann Plast Surg 1994; 32: 411-7.