Hand transplantation: Pertinent data and future outlook

Journal of Hand Surgery

Volumn 24, Issue 5, 1999, Pages 906-913

  Lee, W P Andrew ^a   Mathes, David W ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Composite tissue allografts; Hand transplant; Immunosuppression; Tolerance

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; HYDROCORTISONE; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIBODY; MERCAPTOPURINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISONE; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ALLOGRAFT; BONE MARROW SUPPRESSION; CANCER RISK; DRUG EFFICACY; EXPERIMENTAL TRANSPLANTATION; FLU LIKE SYNDROME; GASTROINTESTINAL TOXICITY; GRAFT SURVIVAL; HAND INJURY; HAND SURGERY; HUMAN; HYPERTENSION; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; INFECTION RISK; LIMB REPLANTATION; LIVER TOXICITY; LUNG EDEMA; LYMPHOPROLIFERATIVE DISEASE; METABOLIC DISORDER; NEPHROTOXICITY; NEUROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVIEW; RISK BENEFIT ANALYSIS; TREATMENT OUTCOME;

EID: 0032861011     PISSN: 03635023     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhsu.1999.0906     Document Type: Article

References (47)

1. Malt R A, McKhann C F. Replantation of severed arms. JAMA. 189:1964;716-722.
2. Chen Z-W, Meyer V E, Kleinert H E, Beasley R W. Present indications and contraindications for replantation as reflected by long-term functional results. Orthop Clin North Am. 12:1981;849-870.
3. Wang S-H, Young K-F, Wei J-N. Replantation of severed limbs - clinical analysis of 91 cases. J Hand Surg. 6:1981;311-318.
4. Meyer V E. Hand amputations proximal but close to the wrist joint: prime candidates for reattachment (long-term functional results). J Hand Surg. 10A:1985;989-991.
5. Chen Z W, Yu H. Current procedures in China of replantation of severed limbs and digits. Clin Orthop. 18:1987;215-223.
6. Tamai S. Twenty years' experience of limb replantation - review of 293 upper extremity replants. J Hand Surg. 7:1982;549-556.
7. Ipsen T, Lundkvist L, Barfred T, Pless J. Principles of evaluation and results in microsurgical treatment of major limb amputations: a follow-up study of 26 consecutive cases 1978-1987. Scand J Plast Reconstr Hand Surg. 24:1990;75-80.
8. Vanstraelen P, Papini R PG, Sykes P J, Milling M AP. The functional results of hand replantation: the Chepstow experience. J Hand Surg. 18B:1993;556-564.
9. Blomgren I, Blomqvist G, Ejeskär A, Fogdestam I, Volkman R, Edshage S. Hand function after replantation or revascularization of upper extremity injuries: a follow-up study of 21 cases operated on 1979-1985 in Göteborg. Scand J Plast Reconstr Surg. 22:1988;93-101.
10. Lee W PA, Yaremchuk M J, Pan Y C. Relative antigenicity of components of a vascularized limb allograft. Plast Reconstr Surg. 87:1991;401-411.
11. Randolph M, Lee W PA. Relative antigenicity of limb allograft components and differential rejection. Hewitt C, Black K. Composite tissue transplantation. 1999;9-29 RG Landers, Austin.
12. Black K S, Hewitt C W, Fraser L A. Composite tissue (limb) allografts in rats: II. Indefinite survival using low-dose cyclosporine. Transplantation. 39:1985;365-368.
13. Hewitt C W, Black K S, Dowdy S F. Composite tissue (limb) allografts in rats: III. Development of donor-host lymphoid chimeras in long-term survivors. Transplantation. 41:1986;39-43.
14. Black K S, Hewitt C W, Hwang J S, Borger R W, Achauer B M. Dose response of cyclosporine-treated composite tissue allografts in a strong histoincompatible rat model. Transplant Proc. 20:1988;266-268.
15. Kuroki H, Ishida O, Daisaku H. Morphological and immunological analysis of rats with long-term-surviving limb allografts induced by a short course of FK 506 or cyclosporine. Transplant Proc. 23:1991;516-520.
16. Hotokebuchi T, Arai K, Takagishi K, Arita C, Sugioka Y, Kaibara N. Limb allografts in rats immunosuppressed with cyclosporine: as a whole-joint allograft. Plast Reconstr Surg. 83:1989;1027-1036.
17. Lee W PA, Pan Y-C, Kesmarky S. Experimental orthotopic transplantation of vascularized skeletal allografts: functional assessment and long-term survival. Plast Reconstr Surg. 95:1995;336-349.
18. Büttemeyer R, Jones N F, Min Z, Rao U. Rejection of the component tissues of limb allografts in rats immunosuppressed with FK-506 and cyclosporine. Plast Reconstr Surg. 97:1996;139-148.
19. Arai K, Hotokebuchi T, Miyahara H. Limb allografts in rats immunosuppressed with FK506: I. Reversal of rejection and indefinite survival. Transplantation. 48:1989;782-786.
20. Benhaim P, Anthony J P, Lin L Y-T, McCalmont T H, Mathes S J. A long-term study of allogeneic rat hindlimb transplants immunosuppressed with RS-61443. Transplantation. 56:1993;911-917.
21. Benhaim P, Anthony J P, Ferreira L, Borsanyi J-P, Mathes S J. Use of combination of low-dose cyclosporine and RS-61443 in a rat hindlimb model of composite tissue allotransplantation. Transplantation. 61:1996;527-532.
22. Pescovitz M D, Sachs D H, Lunney J K, Hsu S M. Localization of class II MHC antigens on porcine renal vascular endothelium. Transplantation. 37:1984;627-630.
23. Goldwyn R M, Beach P M, Feldman D, Wilson R E. Canine limb homotransplantation. Plast Reconstr Surg. 37:1966;184-195.
24. Lance E M, Inglis A E, Figarola F, Veith F J. Transplantation of the canine hind limb: Surgical technique and methods of immunosuppression for allotransplantation - a preliminary report. J Bone Joint Surg. 53A:1971;1137-1149.
25. Üstüner E T, Zdichavsky M, Ren X. Long-term composite tissue allograft survival in a porcine model with cyclosporine/mycophenolate mofetil therapy. Transplantation. 66:1998;1581-1587.
26. Daniel R K, Egerszegi E P, Samulack D D, Skanes S E, Dykes R W, Rennie W RJ. Tissue transplants in primates for upper extremity reconstruction: a preliminary report. J Hand Surg. 11A:1986;1-8.
27. Samulack D D, Dykes R W, Munger B L. Neurophysiologic aspects of allogeneic skin and upper extremity composite tissue transplantation in primates. Transplant Proc. 20:1988;279-290.
28. Stark G B, Swartz W M, Narayanan K, Mller A R. Hand transplantation in baboons. Transplant Proc. 19:1987;3968-3971.
29. Hovius S ER, Stevens H PJD, van Nierop P WM. Allogeneic transplantation of the radial side of the hand in the rhesus monkey: I. Technical aspects. Plast Reconstr Surg. 89:1992;700-709.
30. Lee W PA, Butler P EM. Transplant biology and applications to plastic surgery. Aston S J, Beasley R W, Thorne C HM. Grabb and Smith's Plastic Surgery. 1997;27-37 Lippincott-Raven, Philadelphia.
31. Myers B D, Ross J, Newton L, Luetscher J, Perlroth M. Cyclosporine-associated chronic nephropathy. N Engl J Med. 311:1984;699-705.
32. Starzl T E, Todo S, Demetris A J, Fung J J. Tacrolimus (FK506) and the pharmaceutical/academic/regulatory gauntlet. Am J Kidney Dis. 31:1998;S7-S14.
33. Starzl T E, Fung J, Jordan M. Kidney transplantation under FK 506. JAMA. 264:1990;63-67.
34. Shapiro R, Fung J J, Jain A B, Parks P, Todo S, Starzl T E. The side effects of FK 506 in humans. Transplant Proc. 22:1990;35-36.
35. Kahan B D, Ghobrial R. Immunosuppressive agents. Surg Clin North Am. 74:1994;1029-1054.
36. Dummer J S, Hardy A, Poorsattar A, Ho M. Early infections in kidney, heart, and liver transplant recipients on cyclosporine. Transplantation. 36:1983;259-267.
37. Fishman J A, Rubin R H. Infection in organ-transplant recipients. N Engl J Med. 338:1998;1741-1751.
38. Kontoyiannis D P, Rubin R H. Infection in the organ transplant recipient: an overview. Infect Dis Clin North Am. 9:1995;811-822.
39. Shaw L M, Kaplan B, Kaufman D. Toxic effects of immunosuppressive drugs: mechanisms and strategies for controlling them. Clin Chem. 42:1996;1316-1321.
40. Penn I. Malignancy. Surg Clin North Am. 74:1994;1247-1257.
41. Lee W PA, Rubin J P, Cober S, Ierino F, Randolph M A, Sachs D H. Use of swine model in transplantation of vascularized skeletal tissue allografts. Transplant Proc. 30:1998;2743-2745.
42. Owen R D. Immunogenetic consequences of vascular anastomoses between bovine twins. Science. 102:1945;400.
43. Billingham R E, Brent L, Medawar P B. 'Actively acquired tolerance' of foreign cells. Nature. 172:1953;603.
44. Rubin J, Cober S, Butler P, Lee W PA. Induction of transplant tolerance in large animal model without long-term immunosuppression: strategies to manipulate the immune system of the fetal and the adult recipient. Hewitt C, Black K. Composite tissue transplantation. 1999;31-40 RG Landers, Austin.
45. Russell R C, O'Brien B M, Morrison W A, Pamamull G, MacLeod A. The late functional results of upper limb revascularization and replantation. J Hand Surg. 9A:1984;623-633.
46. Tark K C, Kim Y W, Lee Y H, Lew J D. Replantation and revascularization of hands: clinical analysis and functional results of 261 cases. J Hand Surg. 14A:1989;17-27.
47. Axelrod T S, Buchler U. Severe complex injuries to the upper extremity: revascularization and replantation. J Hand Surg. 16A:1991;574-584.