Genetic modifiers of the Kvβ2-null phenotype in mice

Genes, Brain and Behavior

Volumn 4, Issue 2, 2005, Pages 77-88

  Connor, J X ^a,b   McCormack, K ^c   Pletsch, A ^b   Gaeta, S ^a   Ganetzky, B ^b   Chiu, S Y ^b   Messing, A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c Icagen Inc   (United States)

Author keywords

Auxiliary subunits; Basket cells; Inbred mouse strains; Myoclonus; Voltage gated potassium channels

Indexed keywords

POTASSIUM CHANNEL;

ALPHA CHAIN; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DNA MODIFICATION; GENE EXPRESSION; GENE LOCATION; IMMUNOFLUORESCENCE; KNOCKOUT MOUSE; LIFESPAN; MALE; MOUSE; MYOCLONUS SEIZURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEIZURE SUSCEPTIBILITY; STRAIN DIFFERENCE; SURVIVAL RATE; SWIMMING; THERMOREGULATION;

ANIMALS; BODY TEMPERATURE REGULATION; CEREBELLUM; COLD; EPILEPSY; EXONS; KV1.1 POTASSIUM CHANNEL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCLONUS; PHENOTYPE; POTASSIUM CHANNELS, VOLTAGE-GATED; SEVERITY OF ILLNESS INDEX; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; SPECIES SPECIFICITY; SURVIVAL RATE; SWIMMING;

MAMMALIA;

EID: 14744293297     PISSN: 16011848     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2004.00094.x     Document Type: Article

References (38)

1. Accili, E.A., Kiehn, J., Wible, B.A. & Brown, A.M. (1997) Interactions among inactivating and noninactivating Kvβ subunits, and Kvα1.2, produce potassium currents with intermediate inactivation. J Biol Chem 212, 28232-28236.
2. Akhtar, S., McIntosh, P., Bryan-Sisneros, A., Barratt, L., Robertson, B. & Dolly, J.O. (1999) A functional spliced-variant of β2 subunit of Kv1 channels in C6 glioma cells and reactive astrocytes from rat lesioned cerebellum. Biochemistry 38, 16984-16992.
3. Campomanes, C.R., Carroll, K.I., Manganas, L.N., Hershberger, M.E., Gong, B., Antonucci, D.E., Rhodes, K.J. & Trimmer, J.S. (2002) Kvβ subunit oxidoreductase activity and Kv1 potassium channel trafficking. J Biol Chem 277, 8298-8305.
4. Coleman, S.K., Newcombe, J., Pryke, J. & Dolly, J.O. (1999) Subunit composition of Kv1 channels in human CNS. J Neurochem 73, 849-858.
5. Davis, W.M. & King, W.T. (1967) Pharmacogenetic factor in the convulsive responses of mice to flurothyl. Experientia 23, 214-215.
6. + channel β-subunit (hKvβ1.3) is produced via alternative mRNA splicing. J Biol Chem 270, 28531-28534.
7. + channel β subunit expressed in human heart. Proc Natl Acad Sci USA 92, 6309-6313.
8. Ferraro, T.N., Golden, G.T., Smith, G.G., St Jean, P., Schork, N.J., Mulholland, N., Ballas, C., Schul, J., Buono, R.J. & Berrettini, W.H. (1999) Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice. J Neurosci 19, 6733-6739.
9. + channel β subunit to specifically enhance Kv2.2 (CDRK) expression. J Biol Chem 271, 26341-26348.
10. + channel inactivation, spike broadening, and after-hyperpolarization in Kvβ 1.1-deficient mice with impaired learning. Learn Mem 5, 257-273.
11. Gu, C., Jan, Y.N. & Jan, L.Y. (2003) A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. Science 301, 646-649.
12. Heinemann, S.H., Rettig, J., Wunder, F. & Pongs, O. (1995) Molecular and functional characterization of a rat brain Kvβ3 potassium channel subunit. FEBS Lett 377, 383-389.
13. Heinemann, S.H., Rettig, J., Graack, H.R. & Pongs, O. (1996) Functional characterization of Kv channel β-subunits from rat brain. J Physiol 493, 625-633.
14. Kosobud, A.E., Cross, S.J. & Crabbe, J.C. (1992) Neural sensitivity to pentylenetetrazol convulsions in inbred and selectively bred mice. Brain Res 592, 122-128.
15. Kuryshev, Y.A., Wible, B.A., Gudz, T.I., Ramirez, A.N. & Brown, A.M. (2001) KChAP/Kvβ1.2 interactions and their effects on cardiac Kv channel expression. Am J Physiol Cell Physiol 281, C290-C299.
16. Leicher, T., Roeper, J., Weber K., Wang, X. & Pongs, O. (1996) Structural and functional characterization of human potassium channel subunit β1 (KCNA1B). Neuropharmacology 35, 787-795.
17. Leicher, T., Bähring, R., Isbrandt, D. & Pongs, O. (1998) Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. J Biol Chem 273, 35095-35101.
18. Li H.S. (1992) Genetic influences on susceptibility of the auditory system to aging and environmental factors. Scandinavian Audiology Supplementum. 36, 1-39.
19. Lu X., Skamene E. & Richardson P.M. (1994) Studies of axonal regeneration in C57BL/6J and A/J mice. Brain Res 652, 174-176.
20. + channel β1 gene and functional expression of the β2 gene product. FEBS Lett 370, 32-36.
21. + channel β-subunit Kvβ2 (Kcnab2). J Biol Chem 277, 13219-13228.
22. Need, A.C., Irvine, E.E. & Giese, K.P. (2003) Learning and memory impairments in Kvβ1.1-null mutants are rescued by environmental enrichment or ageing. Eur J Neurosci 18, 1640-1644.
23. Pavlidis, P. & Noble, W.S. (2001) Analysis of strain and regional variation in gene expression in mouse brain. Genome Biol 2, Research 0042
24. Ramírez-Solis, R., Davis, A.C. & Bradley, A. (1993) Gene targeting in embryonic stem cells. Methods Enzymol 225, 855-878.
25. + channels altered by presence of β-subunit. Nature 369, 289-294.
26. + channel β subunits: expression and distribution of Kvβ1 and Kvβ2 in adult rat brain. J Neurosci 16, 4846-4860.
27. Robinson S.F., Marks, M.J. & Collins A.C. (1996) Inbred mouse strains vary in oral self-selection of nicotine. Psycopharmacology 124, 332-339.
28. Sandberg, R., Yasuda, R., Pankratz, D.G., Carter, T.A., Del Rio, J.A., Wodicka, L., Mayford, M., Lockhart, D.J. & Barlow, C. (2000) Regional and strain-specific gene expression mapping in the adult mouse brain. Proc Natl Acad Sci USA 97,11038-11043.
29. Schultz, D., Litt, M., Smith, L., Thayer, M. & McCormack, K. (1996) Localization of two potassium channel β subunit genes, KCNA1B and KCNA2B. Genomics 31, 389-391.
30. + channel surface expression through effects early in biosynthesis. Neuron 16, 843-852.
31. Smart, S.L., Lopantsev, V., Zhang, C.L., Robbins, C.A., Wang, H., Chiu, S.Y., Schwartzkroin, P.A., Messing, A. & Tempel, B.L. (1998) Deletion of the Kv1.1 potassium channel causes epilepsy in mice. Neuron 20, 809-819.
32. Soriano, P., Montgomery, C., Geske, R. & Bradley, A. (1991) Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64, 693-702.
33. + channel by the β subunit, Kvβ1 and lack of effect of a Kvβ1 N-terminal peptide. FEBS Lett 378, 250-252.
34. Storer J.B. (1966) Longevity and gross pathology at death in 22 inbred mouse strains. J Geront 21, 404-409.
35. Tunnicliff G., Wimer C.C. & Wimer R.E. (1973) Relationships between neurotransmitter metabolism and behaviour in seven inbred strains of mice. Brain Res 61, 428-434.
36. Wang, Z., Kiehn, J., Yang, Q., Brown, A.M. & Wible, B.A. (1996) Comparison of binding and block produced by alternatively spliced Kvβ1 subunits. J Biol Chem 271, 28311-28317.
37. + channels in transfected mammalian cells. J Biol Chem 272, 11728-11735.
38. Zhou, L., Zhang, C.L., Messing, A. & Chiu, S.Y. (1998) Temperature-sensitive neuromuscular transmission in Kv1.1 null mice: role of potassium channels under the myelin sheath in young nerves. J Neurosci 18, 7200-7215.