-
1
-
-
0028306517
-
Synthesis, oral bioavailability determination, in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonylmethoxy) ethyl] adenine (PMEA)
-
Starrett JE Jr, Tortolani DR, Russell J, et al. Synthesis, oral bioavailability determination, in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonylmethoxy) ethyl] adenine (PMEA) [J]. J Med Chem, 1994, 37(12):1857.
-
(1994)
J Med Chem
, vol.37
, Issue.12
, pp. 1857
-
-
Starrett Jr., J.E.1
Tortolani, D.R.2
Russell, J.3
-
2
-
-
0025924186
-
Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis
-
Yokota T, Mochizuki S, Konno K, et al. Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis[J]. Antimicrob Agents Chemother, 1991, 35(2):394.
-
(1991)
Antimicrob Agents Chemother
, vol.35
, Issue.2
, pp. 394
-
-
Yokota, T.1
Mochizuki, S.2
Konno, K.3
-
3
-
-
0027253824
-
Inhibitory effect of 9-(2-phosphonyl methoxyethyl) adenine (PMEA) on human and duck hepatitis B virus infection
-
Heijtink RA, Wilde GAD, Kruining J, et al. Inhibitory effect of 9-(2-phosphonyl methoxyethyl) adenine (PMEA) on human and duck hepatitis B virus infection[J]. Antiviral Res, 1993, 21:141.
-
(1993)
Antiviral Res
, vol.21
, pp. 141
-
-
Heijtink, R.A.1
Wilde, G.A.D.2
Kruining, J.3
-
4
-
-
0025647251
-
Therapeutic potential of phosphonyhnethoxyalkylpurines and pyrimidines as antiviral agents
-
de Clercq E. Therapeutic potential of phosphonyhnethoxyalkylpurines and pyrimidines as antiviral agents[J]. Drugs Exp Clin Res, 1990, 16 (7):319.
-
(1990)
Drugs Exp Clin Res
, vol.16
, Issue.7
, pp. 319
-
-
De Clercq, E.1
-
5
-
-
0036148731
-
Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro
-
Delmas J, Schorr O, Jamard C, et al. Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro [J]. Antimicrob Agents Chemother, 2002, 46(2):425.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, Issue.2
, pp. 425
-
-
Delmas, J.1
Schorr, O.2
Jamard, C.3
-
6
-
-
0025767013
-
Celluer uptake of phosphonylmethoxyalkyl purine derivatives
-
Palu G, Stefanelli S, Rassu M, et al. Celluer uptake of phosphonylmethoxyalkyl purine derivatives[J]. Antiviral Res, 1991, 16(1):115.
-
(1991)
Antiviral Res
, vol.16
, Issue.1
, pp. 115
-
-
Palu, G.1
Stefanelli, S.2
Rassu, M.3
-
7
-
-
0028792567
-
Clinical pharmacokinetics of adefovir in human immunodeficiency virus type-1 infected patients
-
Cundy KC, Barditch-Crovo P, Walker R, et al. Clinical pharmacokinetics of adefovir in human immunodeficiency virus type-1 infected patients[J]. Antimicrob Agents Chemother, 1995, 39(11):2401.
-
(1995)
Antimicrob Agents Chemother
, vol.39
, Issue.11
, pp. 2401
-
-
Cundy, K.C.1
Barditch-Crovo, P.2
Walker, R.3
-
8
-
-
0032887069
-
Adefovir dipivoxil
-
Stuart N, Karen LG. Adefovir dipivoxil[J]. Drugs, 1999, 58(3): 479.
-
(1999)
Drugs
, vol.58
, Issue.3
, pp. 479
-
-
Stuart, N.1
Karen, L.G.2
-
9
-
-
0026020310
-
Intracelluar metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonyhnethoxyethyl) adenine, a potent anti-HIV compound
-
Balzarini J, Hao Z, Herdewijn P, et al. Intracelluar metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonyhnethoxyethyl) adenine, a potent anti-HIV compound[J]. Proc Natl Acad Sci, 1991, 88(4):1499.
-
(1991)
Proc Natl Acad Sci
, vol.88
, Issue.4
, pp. 1499
-
-
Balzarini, J.1
Hao, Z.2
Herdewijn, P.3
-
10
-
-
0028286804
-
Oral bioavailability of the antiretroviral agent 9-(2- phosphonylmethoxyethyl) adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys
-
Cundy KC, Fishback JA , Shaw PC, et al. Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys [J]. Pharm Res, 1994, 11(6): 839.
-
(1994)
Pharm Res
, vol.11
, Issue.6
, pp. 839
-
-
Cundy, K.C.1
Fishback, J.A.2
Shaw, P.C.3
-
11
-
-
0030997246
-
Pharmacokinetics and metabolism of selected prodrug of PMEA in rats
-
Shaw JP, Louie MS, Krishnamurthy VV, et al. Pharmacokinetics and metabolism of selected prodrug of PMEA in rats[J]. Drug Metab Dapos, 1997, 25(3):362.
-
(1997)
Drug Metab Dapos
, vol.25
, Issue.3
, pp. 362
-
-
Shaw, J.P.1
Louie, M.S.2
Krishnamurthy, V.V.3
-
12
-
-
0030045493
-
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxy-ethyl) adenine, the bis (pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxy-ethyl) adenine
-
Naesens L, Balzarini J, Bischofberger N, et al. Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2- phosphonylmethoxy-ethyl) adenine, the bis (pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxy-ethyl) adenine[J]. Antimicrob Agents Chemother, 1996, 40(1):22.
-
(1996)
Antimicrob Agents Chemother
, vol.40
, Issue.1
, pp. 22
-
-
Naesens, L.1
Balzarini, J.2
Bischofberger, N.3
-
13
-
-
0034806770
-
Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-inficted woodchucks
-
Cullen JM, Daniel HL, Brown C, et al. Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-inficted woodchucks[J]. Am Soc Microbiol ,2001, 45(10): 2740.
-
(2001)
Am Soc Microbiol
, vol.45
, Issue.10
, pp. 2740
-
-
Cullen, J.M.1
Daniel, H.L.2
Brown, C.3
-
14
-
-
0031445754
-
Oral formulations of adefovir dipivoxil: In vitro dislution and in vivo bioaviailability in dogs
-
Cundy KC, Sue IL, Visor GC, et al. Oral formulations of adefovir dipivoxil: in vitro dislution and in vivo bioaviailability in dogs[J]. J Pharm Sci, 1997, 86(12):1334.
-
(1997)
J Pharm Sci
, vol.86
, Issue.12
, pp. 1334
-
-
Cundy, K.C.1
Sue, I.L.2
Visor, G.C.3
-
16
-
-
0026779379
-
Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine
-
Naesens L, Balzarini J, Clercq ED. Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine[J]. Drug Metab Dispos, 1992, 20(5):747.
-
(1992)
Drug Metab Dispos
, vol.20
, Issue.5
, pp. 747
-
-
Naesens, L.1
Balzarini, J.2
Clercq, E.D.3
-
17
-
-
0033823056
-
Novel hepatotiophic prodrugs of the antiviral nuleoside 9-(2-phosphonyl-methoxyethyl) adenine with improved pharmacokinetics and antiviral activity
-
Biessen EAL, Valentijn ARPM, Vrueh RLADE, et al. Novel hepatotiophic prodrugs of the antiviral nuleoside 9-(2-phosphonyl-methoxyethyl) adenine with improved pharmacokinetics and antiviral activity[J]. FASEB J, 2000, 14(12):1784.
-
(2000)
FASEB J
, vol.14
, Issue.12
, pp. 1784
-
-
Biessen, E.A.L.1
Valentijn, A.R.P.M.2
Vrueh, R.L.A.D.E.3
-
18
-
-
0030842430
-
Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil 9-(2-(bispivaloyl-oxymethyl) phosphonomethoxy) ethyl adenine in HIV-infected patients
-
Baiditch CP, Toole J, Hendrix CW, et al. Anti-Human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil 9-(2-(bispivaloyl-oxymethyl) phosphonomethoxy) ethyl] adenine in HIV-infected patients [J]. J Infec Dis, 1997, 176(2):406.
-
(1997)
J Infec Dis
, vol.176
, Issue.2
, pp. 406
-
-
Baiditch, C.P.1
Toole, J.2
Hendrix, C.W.3
-
19
-
-
0034075753
-
Single-dose pharmacokinetics and safety of the oral antivrial compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1
-
Hughes WT, Shenep JL, Rodman JH, et al. Single-dose pharmacokinetics and safety of the oral antivrial compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1[J]. Antimicrob Agents Chemother, 2000, 44(4):1041.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, Issue.4
, pp. 1041
-
-
Hughes, W.T.1
Shenep, J.L.2
Rodman, J.H.3
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