An IκB-β COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress

Journal of Cellular Physiology

Volumn 203, Issue 1, 2005, Pages 186-192

  Lao, Qizong ^a   Kuge, Osamu ^b   Fukamachi, Toshihiko ^a   Kakegawa, Tomohito ^a   Saito, Hiromi ^a   Nishijima, Masahiro ^c   Kobayashi, Hiroshi ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; ADENOSINE TRIPHOSPHATASE; COMPLEMENTARY DNA; COTRANSPORTER; I KAPPA B BETA; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 (N ETHYL N ISOPROPYL)AMILORIDE; AMILORIDE; ANTIARRHYTHMIC AGENT; DRUG DERIVATIVE; I KAPPA B; MACROLIDE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHINESE HAMSTER; CHO CELL; DNA SEQUENCE; GENETIC TRANSFECTION; HOMEOSTASIS; MOLECULAR CLONING; NONHUMAN; OVARY CELL; PHOTON; PRIORITY JOURNAL; PROTEIN EXPRESSION; ADAPTATION; ANIMAL; CELL CLONE; CELL DIVISION; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; CRICETULUS; CYTOLOGY; CYTOSOL; DRUG EFFECT; FEMALE; GENETICS; HAMSTER; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; NUCLEOTIDE SEQUENCE; OVARY; PH; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ACIDS; ADAPTATION, PHYSIOLOGICAL; AMILORIDE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BASE SEQUENCE; CELL DIVISION; CERCOPITHECUS AETHIOPS; CHO CELLS; CLONE CELLS; COS CELLS; CRICETINAE; CRICETULUS; CYTOSOL; DNA, COMPLEMENTARY; FEMALE; HOMEOSTASIS; HYDROGEN-ION CONCENTRATION; I-KAPPA B PROTEINS; MACROLIDES; MOLECULAR SEQUENCE DATA; MUTAGENESIS; OVARY; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION;

EID: 14744278599     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20221     Document Type: Article

References (35)

1. Aharonovitz O, Zaun HC, Balla T, York JD, Orlowski J, Grinstein S. 2000. Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate. J Cell Biol 150(1):213-224.
2. +-ATPase by lethal acid stress in cultured inner medullary collecting duct cells. Am J Physiol 273(4 Pt 1):C1194-C1205.
3. Beg AA, Baldwin AS, Jr. 1993. The I kappa B proteins: Multifunctional regulators of Rel/NF-kappa B transcription factors. Genes Dev 7(11):2064-2070.
4. Bernard D, Gosselin K, Monte D, Vercamer C, Bouali F, Pourtier A, Vandenbunder B, Abbadie C. 2004. Involvement of Rel/nuclear factor-kappaB transcription factors in keratinocyte senescence. Cancer Res 64(2):472-481.
5. - exchange systems in Chinese hamster lung fibroblasts. J Biol Chem 263(13):6122-6127.
6. Chaplin DJ, Olive PL, Durand RE. 1987. Intermittent blood flow in a murine tumor: Radiobiological effects. Cancer Res 47(2):597-601.
7. Chiu HM, Lin HH, Tang MJ. 1998. Ethyl isopropylamiloride downregulates Na,K-ATPase gene expression which confers cytotoxicity in primary proximal tubule cell cultures. Chin J Physiol 41(4):195-202.
8. Chu ZL, McKinsey TA, Liu L, Qi X, Ballard DW. 1996. Basal phosphorylation of the PEST domain in the I(kappa)B(beta) regulates its functional interaction with the c-rel proto-oncogene product. Mol Cell Biol 16(11):5974-5984.
9. +-coupled bicarbonate transport in cultured rat hepatocytes. Am J Physiol 256(3 Pt 1):G491-G500.
10. Fukamachi T, Saito H, Kakegawa T, Kobayashi H. 2002. Different proteins are phosphorylated under acidic environments in Jurkat cells. Immunol Lett 82(1-2):155-158.
11. Ghosh S, Karin M. 2002. Missing pieces in the NF-kappaB puzzle. Cell 109(Suppl):S81-S96.
12. Grilli M, Chiu JJ, Lenardo MJ. 1993. NF-kappa B and Rel: Participants in a multiform transcriptional regulatory system. Int Rev Cytol 143:1-62.
13. + exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys Acta 988(1):73-97.
14. Johnson C, Van Antwerp D, Hope TJ. 1999. An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha. EMBO J 18(23):6682-6693.
15. Kuge O, Nishijima M, Akamatsu Y. 1986. Phosphatidylserine biosynthesis in cultured Chinese hamster ovary cells. II. Isolation and characterization of phosphatidylserine auxotrophs. J Biol Chem 261(13):5790-5794.
16. Lee AH, Tannock IF. 1998. Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells. Cancer Res 58(9):1901-1908.
17. Martin GR, Jain RK. 1994. Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy. Cancer Res 54(21):5670-5674.
18. McKinsey TA, Chu ZL, Ballard DW. 1997. Phosphorylation of the PEST domain of IkappaBbeta regulates the function of NF-kappaB/IkappaBbeta complexes. J Biol Chem 272(36):22377-22380.
19. Naglich JG, Metherall JE, Russell DW, Eidels L. 1992. Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor. Cell 69(6):1051-1061.
20. Nemeth-Cahalan KL, Hall JE. 2000. pH and calcium regulate the water permeability of aquaporin 0. J Biol Chem 275(10):6777-6782.
21. + exchangers of mammalian cells. J Biol Chem 272(36):22373-22376.
22. Pahl HL. 1999. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18(49):6853-6866.
23. + antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH. Proc Natl Acad Sci USA 81(15):4833-4837.
24. Schwartz JH, Masino SA, Nichols RD, Alexander EA. 1994. Intracellular modulation of acid secretion in rat inner medullary collecting duct cells. Am J Physiol 266(1 Pt 2):F94-F101.
25. Shih C, Shilo BZ, Goldfarb MP, Dannenberg A, Weinberg RA. 1979. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc Natl Acad Sci USA 76(11):5714-5718.
26. Shubik P. 1982. Vascularization of tumors. J Cancer Res Clin Oncol 103(3):211-226.
27. Takeshita K, Suzuki Y, Nishio K, Takeuchi O, Toda K, Kudo H, Miyao N, Ishii M, Sato N, Naoki K, Aoki T, Suzuki K, Hiraoka R, Yamaguchi K. 2003. Hypercapnic acidosis attenuates endotoxin-induced nuclear factor-[kappa]B activation. Am J Respir Cell Mol Biol 29(1):124-132.
28. Tannock IF, Rotin D. 1989. Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res 49(16):4373-4384.
29. Thangaraju M, Sharma K, Liu D, Shen SH, Srikant CB. 1999. Interdependent regulation of intracellular acidification and SHP-1 in apoptosis. Cancer Res 59(7):1649-1654.
30. Tran K, Merika M, Thanos D. 1997. Distinct functional properties of IkappaB alpha and IkappaB beta. Mol Cell Biol 17(9):5386-5399.
31. Vaupel P, Kallinowski F, Okunieff P. 1989. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors. Cancer Res 49(23):6449-6465.
32. --dependent alkalinizing mechanism. Biochem Biophys Res Commun 253(2):320-324.
33. Wike-Hooley JL, Haveman J, Reinhold HS. 1984. The relevance of tumour pH to the treatment of malignant disease. Radiother Oncol 2(4):343-366.
34. Xu L, Fidler IJ. 2000. Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells. Cancer Res 60(16):4610-4616.
35. Yamagata M, Hasuda K, Stamato T, Tannock IF. 1998. The contribution of lactic acid to acidification of tumours: Studies of variant cells lacking lactate dehydrogenase. Br J Cancer 77(11):1726-1731.