Development of a technique to determine bicyclomycin-rho binding and stoichiometry by isothermal titration calorimetry and mass spectrometry

Journal of the American Chemical Society

Volumn 127, Issue 8, 2005, Pages 2741-2751

  Brogan, Andrew P ^a   Widger, William R ^b   Bensadek, Dalila ^c   Riba Garcia, Isabel ^c   Gaskell, Simon J ^c   Kohn, Harold ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b University of Houston   (United States)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; CALORIMETRY; ENZYME INHIBITION; HYDROLYSIS; PROTEINS; REACTION KINETICS; RNA; STOICHIOMETRY; TITRATION;

BICYCLOMYCIN; HEXAMERIC HELICASE; HEXAMERS; ISOTHERMAL TITRATION CALORIMETRY (ITC);

BINDING ENERGY;

5A (3 FORMYLPHENYLSULFANYL)DIHYDROBICYCLOMYCIN; ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN; BICOZAMYCIN; BICOZAMYCIN DERIVATIVE; IMINE; NATURAL PRODUCT; RHO FACTOR; RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME MECHANISM; ISOTHERMAL TITRATION CALORIMETRY; MASS SPECTROMETRY; PROTEIN HYDROLYSIS; RNA TRANSCRIPTION; STOICHIOMETRY;

ADENOSINE TRIPHOSPHATASES; ALDEHYDES; ANTI-BACTERIAL AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; CALORIMETRY; KINETICS; PROTEIN BINDING; RHO FACTOR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TITRIMETRY;

EID: 14744267536     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja046441q     Document Type: Article

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