Role of the C(5)-C(5a) exomethylene group in bicyclomycin: Synthesis, structure, and biochemical and biological properties

Journal of Organic Chemistry

Volumn 61, Issue 22, 1996, Pages 7764-7776

  Park, Hyeung Geun ^a   Zhang, Zhuming ^a   Zhang, Xiangdong ^a   Widger, William R ^b   Kohn, Harold ^a  

^a University of Houston   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTIBIOTIC AGENT; BICOZAMYCIN; BICOZAMYCIN DERIVATIVE; TRANSCRIPTION FACTOR;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION TERMINATION;

EID: 0029848072     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo961004i     Document Type: Article

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29. Our findings do not permit us to differentiate this effect from stabilizing interactions that may be derived from the π-electrons localized at C(5) within the bicyclomycin derivative and the receptor.
30. For a discussion of enzyme irreversible inactivators, see: (a) Silverman, R. B. The Organic Chemistry of Drug Design and Drug Action; Academic Press: San Diego, 1992; pp 178-219. (b) Bayley, H.; Staros, J. V. Photoaffinity Labeling and Related Techniques. In Azides and Nitrenes: Reactivity and Utility; Scriven, E. F. V., Ed.; Academic Press: Orlando, 1984; pp 433-490. (c) Fleming, S. A. Tetrahedron 1995, 51, 12479-12520.
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32. For a discussion of enzyme irreversible inactivators, see: (a) Silverman, R. B. The Organic Chemistry of Drug Design and Drug Action; Academic Press: San Diego, 1992; pp 178-219. (b) Bayley, H.; Staros, J. V. Photoaffinity Labeling and Related Techniques. In Azides and Nitrenes: Reactivity and Utility; Scriven, E. F. V., Ed.; Academic Press: Orlando, 1984; pp 433-490. (c) Fleming, S. A. Tetrahedron 1995, 51, 12479-12520.