Reproductive and sexual behavior changes in male rats exposed perinatally to picrotoxin

Reproductive Toxicology

Volumn 19, Issue 4, 2005, Pages 541-546

  Yasuhara, F ^a   Kempinas, W G ^a   Pereira, O C M ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Corticosteroid; Fertility; GABA; Picrotoxin; Rat; Reproductive function; Sexual differentiation; Sperm production; Testosterone

Indexed keywords

ESTROGEN; PICROTOXIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIRTH WEIGHT; CASTRATION; CONTROLLED STUDY; LACTATION; MALE; MALE FERTILITY; MATING; NONHUMAN; PERINATAL PERIOD; PREGNANCY; PROGENY; RAT; RAT STRAIN; REPRODUCTION; SEX DIFFERENCE; SEXUAL BEHAVIOR; SEXUAL MATURATION; TESTOSTERONE BLOOD LEVEL;

RATTUS NORVEGICUS;

EID: 14644436420     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2004.08.006     Document Type: Article

References (30)

1. M.M. McCarthy, A.M. Davis, and J.A. Mong Excitatory neurotransmission and sexual differentiation of the brain Brain Res Bull 44 1997 487 495
2. N.J. Maclusky, and F. Naftolin Sexual differentiation of the central nervous system Science 211 1981 1294 1303
3. R.W. Rhees, B.A. Kirk, S. Sephton, and E.D. Lephart Effects of prenatal testosterone on sexual behavior, reproductive morphology and LH secretion in the female rat Dev Neurosci 19 1997 430 437
4. R.A. Gorski, R.E. Harlan, C.D. Jacobson, J.E. Shryne, and A.M. Southam Evidence for the existence of a sexually dimorphic nucleus in the preoptic area of the rat J Comp Neurol 193 1980 529 539
5. J. Swann, and J.M. Fiber Sex differences in function of a pheromonally stimulated pathway: role of steroids and the main olfactory system Brain Res Bull 44 1997 409 413
6. S. Li, and G. Pelletier Involvement of serotonin in the regulation of GnRH gene expression in the male rat brain Neuropeptides 29 1995 21 25
7. F. Bach, G. Flugge, and W. Wuttke GABAergic influence on the development of sexually dimorphic nucleus of male and female rats Brain Res 573 1992 341 344
8. A. Fernandez-Guasti, K. Larsson, and C. Beyer GABAergic control of sexual behavior Pharmacol Biochem Behav 24 1986 1065 1070
9. M.R.P. Silva, C.A. Oliveira, L.F. Felicio, A.G. Nasello, and M.M. Bernardi Perinatal treatment with picrotoxin induces sexual, behavioral, and neuroendocrine changes in male rats Pharmacol Biochem Behav 60 1998 203 208
10. S.E. File, and R.G. Lister Does the reduction in social interaction produced by picrotoxin and pentylenetetrazole indicate anxiogenic action? Neuropharmacology 23 1984 793 796
11. L. Ellis, and S. Cole-Harding The effects of prenatal stress, and of prenatal alcohol and nicotine exposure, on human sexual orientation Physiol Behav 74 2001 213 226
12. G.W. Robb, R.P. Amann, and G.J. Killian Daily sperm production and epididymal sperm reserves of pubertal and adult rats J Reprod Fertil 54 1978 103 107
13. E. Arteche, G. Strippoli, G. Loirand, P. Pacaud, L. Candenas, and J.C. Moltó An analysis of the mechanisms involved in the Okadaic Acid - induced contraction of the estrogen-primed rat uterus J Pharmacol Exp Ther 282 1997 201 207
14. S.A. Almeida, W.G. Kempinas, and T.L. Lamano-Carvalho Sexual behavior and fertility of male rats submitted to prolonged immobilization-induced stress Braz J Med Biol Res 33 2000 1105 1109
15. C. Sultan, P. Balaguer, B. Terouanne, V. Georget, F. Paris, and C. Jeandel Environmental xenoestrogens, antiandrogens and disorders of male sexual differentiation Mol Cell Endocrinol 178 2001 99 105
16. O.C.M. Pereira Endocrine disruptors and hypothalamic sexual differentiation Annu Rev Biomed Sci 5 2003 87 94
17. L.G. Dahlof, E. Hard, and K. Larsson Sexual differentiation of offspring of mothers treated with cortisone during pregnancy Physiol Behav 21 1978 673 674
18. C. Gupta, and S.J. Yaffe Prenatal exposure to phenobarbital permanently decreases testosterone and causes reproductive dysfunction Science 216 1982 640 642
19. R.H. Anderson, D.E. Fleming, R.W. Rhees, and E. Kinghorn Relationships between sexual activity, plasma testosterone, and volume of the sexually dimorphic nucleus of the preoptic area in prenatally stressed and non-stressed rats Brain Res 370 1986 1 10
20. L. Ellis, M.A. Ames, W. Peckham, and D. Burke Sexual orientation of human offspring may be altered by severe maternal stress during pregnancy J Sex Res 25 1988 152 157
21. L. Janulis, J.M. Bahr, R.A. Hess, S. Janssen, and Y. Osawa Rat testicular germ cells and epididymal sperm contain active P450 aromatase J Androl 19 1998 65 71
22. R.A. Hess Estrogen in the adult male reproductive tract: a review Reprod Biol Endocrinol 1 2003 52
23. E. Cherubini, J.L. Gaiarsa, and Y. Ben-Ari GABA: an excitatory transmitter in early postnatal life Trends Neurosci 14 1991 515 519
24. S. Segovia, A. Guillamón, M.C.R. Del Cerro, E. Ortega, C. Pérez-Laso, and M. Rodriguez-Zafra The development of brain sex differences: a multisignaling process Behav Brain Res 105 1999 69 80
25. 2+ and modulation of gonadotropin-releasing hormone action in ∝T3-1 gonadotropes J Neuroendocrinol 12 2000 159 166
26. D.B. Adams, W. Boudreau, C.W. Cowan, C. Kokonowski, K. Oberteuffer, and K. Yohay Offense produced by chemical stimulation of the anterior hypothalamus of the rat Physiol Behav 53 1993 1127 1132
27. N.J. MacLusky, D.A. Bowlby, T.J. Brown, R.E. Peterson, and R.B. Hochberg Sex and developing brain: suppression of neuronal estrogen sensitivity by developmental androgen exposure Neurochem Res 22 1997 1395 1414
28. O.C.M. Pereira, F. Yasuhara, and A.C. Arena Cholinergic responses of seminal vesicles isolated from rats exposed perinatally to hydrocortisone Pharmacol Res 48 2003 91 95
29. O.C.M. Pereira, A.C. Arena, F. Yasuhara, and W.G. Kempinas Effects of prenatal hydrocortisone acetate exposure on fertility and sexual behavior in male rats Reg Toxicol Pharmacol 38 2003 36 42
30. E. Teodorov, S.A. Salzgeber, L.F. Felicio, F.M.F. Varolli, and M.M. Bernardi Effects of perinatal picrotoxin and sexual experience on heterosexual and homosexual behavior in male rats Neurotoxicol Teratol 24 2002 235 245