Enhancing DNA vaccine potency against hantavirus by co-administration of interleukin-12 expression vector as a genetic adjuvant

Chinese Medical Journal

Volumn 118, Issue 4, 2005, Pages 313-319

  Zheng, Lan Yan ^a   Mou, Ling ^b   Lin, Song ^b   Lu, Run Ming ^b   Luo, En Jie ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b Department of Laboratory Medicine   (China)

Author keywords

DNA vaccines; Gene adjuvant; Hantavirus; Interleukin 12; Nucleocapsid proteins

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 12; INTERLEUKIN 4; NUCLEOCAPSID PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; GENE CONSTRUCT; GENETIC CODE; HANTAVIRUS; HUMORAL IMMUNITY; LYMPHOCYTE PROLIFERATION; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; OPEN READING FRAME; PHENOTYPE; SPLEEN CELL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VIRUS INFECTION;

ANIMALS; CYTOKINES; GENE THERAPY; HANTAVIRUS; IMMUNOGLOBULIN G; IMMUNOPHENOTYPING; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; NUCLEOCAPSID; VACCINES, DNA; VIRAL VACCINES;

EID: 14644427841     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Schmaljohn C, Hjelle B. Hantaviruses: a global disease problem. Emerg Infect Dis 1997;3:95-104.
2. Hooper JW, Li D. Vaccines against hantaviruses. Curr Top Microbiol Immunol 2001;256:171-191.
3. Lu Q, Zhu Z, Weng J, et al. Immune responses to inactivated vaccine in people naturally infected with hantaviruses. J Med Virol 1996;49:333-335.
4. Lundkvist A, Kallio-Kokko H, Sjolander KB, et al. Characterization of Puumala virus nucleocapsid protein: identification of B-cell epitopes and domains involved in protective immunity. Virology 1996;216:397-406.
5. Kamrud KI, Hooper JW, Elgh F, et al. Comparison of the protective efficacy of naked DNA, DNA-based Sindbis replicon, and packaged Sindbis replicon vectors expressing Hantavirus structural genes in hamsters. Virology 1999;263:209-219.
6. Yoshimatsu K, Yoo YC, Yoshida R, et al. Protective immunity of Hantaan virus nucleocapsid and envelope protein studied using baculovirus-expressed proteins. Arch Virol 1993;130:365-376.
7. Park JM, Cho SY, Hwang YK, et al. Identification of H-2K ( b )-restricted T-cell epitopes within the nucleocapsid protein of Hantan virus and establishment of cytotoxic T-cell clones. J Med Virol 2000; 60: 189-199.
8. Leitner WW, Restifo NP. DNA vaccines and apoptosis: to kill or not to kill? J Clin Invest 2003;112:22-24.
9. Kim JJ, Ayyavoo V, Bagarazzi ML, et al. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J Immunol 1997;158:816-826.
10. Kim JJ, Bagarazzi ML, Trivedi N, et al. Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes. Nat Biotechnol 1997;15:641-646.
11. Chen G, Chen H, Guo H, et al. Protective effect of DNA-mediated immunization with a combination of SAG1 and IL-2 gene adjuvant against infection of Toxoplasma gondii in mice. Chin Med J 2002; 115: 1448-1452.
12. Kim JJ, Simbiri KA, Sin JI, et al. Cytokine molecular adjuvants modulate immune responses induced by DNA vaccine constructs for HIV-1 and SIV. J Interferon Cytokine Res 1999;19:77-84.
13. Sin JI, Kim JJ, Arnold RL, et al. IL-12 gene as a DNA vaccine adjuvant in a herpes mouse model: IL-12 enhances Th1-type CD4 + T cell-mediated protective immunity against herpes simplex virus-2 challenge. J Immunol 1999;162:2912-2921.
14. Chen YL, Wang SN, Yang WJ, et al. Expression and immunogenicity of Mycoplasma hyopneumoniae heat shock protein antigen P42 by DNA vaccination. Infect Immun 2003;71:1155-1160.
15. Cohen AD, Boyer JD, Weiner DB, et al. Modulating the immune response to genetic immunization. FASEB J 1998;12:1611-1626.
16. Bukowski RM. Cytokine combinations: therapeutic use in patients with advanced renal cell carcinoma. Semin Oncol 2000;27:204-212.
17. Hara I, Nagai H, Miyake H, et al. Effectiveness of cancer vaccine therapy using cells transduced with the interleukin-12 gene combined with systemic interleukin-18 administration. Cancer Gene Ther 2000;7:83-90.
18. Zhu M, Xu X, Liu H, et al. Enhancement of DNA vaccine potency against herpes simplex virus 1 by co-administration of an interleukin-18 expression plasmid as a genetic adjuvant. J Med Microbiol 2003;52(Pt3): 223-228.
19. Martin E, Kamath AT, Briscoe H, et al. The combination of plasmid interleukin-12 with a single DNA vaccine is more effective than Mycobacterium bovis (bacille Calmette-Guerin) in protecting against systemic Mycobacterim avium infection. Immunology 2003; 109: 308-314.
20. Oran AE, Robinson HL. DNA vaccines, combining form of antigen and method of delivery to raise a spectrum of IFN-gamma and IL-4-producing CD4 + and CD8 + T cells. J Immunol 2003;171:1999-2005.