A revival of old players

EMBO Reports

Volumn 6, Issue 2, 2005, Pages 126-127

  Nakano, Hiroyasu ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; c Jun amino terminal kinase; JNK; Necrosis; NF B; Reactive oxygen species (ROS)

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIOXIDANT; APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE; FERRITIN; FLICE INHIBITORY PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; X LINKED INHIBITOR OF APOPTOSIS;

ANTIOXIDANT ACTIVITY; APOPTOSIS; CELL DEATH; CELL SURVIVAL; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; REACTIVE OXYGEN SPECIES;

EID: 14644421648     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.7400335     Document Type: Review

References (10)

1. Chen YR, Wang X, Templeton D, Davis RJ, Tan TH (1996) The role of c-Jun N-terminal kinase(JNK) in apoptosis induced by ultraviolet X and γ radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem 271: 31929-31936
2. De Smaele E, Zazzeroni F, Papa S, Nguyen DU, Jin R, Jones J, Cong R, Franzoso G (2001) Induction of gadd45b by NF-κB downregulates proapoptotic JNK signalling. Nature 414: 308-313
3. Karin M, Lin A (2002) NF-κB at the crossroads of life and death. Nat Immunol 3: 221-227
4. Lamb JA, Ventura JJ, Hess P, Flavell RA, Davis RJ (2003) JunD mediates survival signaling by the JNK signal transduction pathway. Mol Cell 11: 1479-1489
5. Nakano H (2004) Signaling crosstalk between NF-κB and JNK. Trends Immunol 25: 402-405
6. Pham CG et al (2004) Ferritin heavy chain upregulation by NF-κB inhibits TNFα-induced apoptosis by suppressing reactive oxygen species. Cell 119: 529-542
7. Sakon S, Xue X, Takekawa M, Sasazuki T, Okazaki T, Kojima Y, Piao JH, Yagita H, Okumura K, Doi T, Nakano H (2003) NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J 22: 3898-3909
8. Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A (2001) Inhibition of JNK activation through NF-κB target genes. Nature 414: 313-317
9. Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H (2001) ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2: 222-228
10. Ventura JJ, Cogswell P, Flavell RA, Baldwin AS Jr, Davis RJ (2004) JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev 18: 2905-2915