P-glycoprotein - A pump of importance for drug response;P-glykoprotein - En pumpe av betydning for legemiddelrespons

Tidsskrift for den Norske Laegeforening

Volumn 124, Issue 22, 2004, Pages 2921-2923

  Molden, Espen ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; AMIODARONE; AMPRENAVIR; ANTIINFECTIVE AGENT; CARDIOVASCULAR AGENT; CLARITHROMYCIN; CYCLOSPORIN; CYTOCHROME P450 3A4; CYTOSTATIC AGENT; DAUNORUBICIN; DOXORUBICIN; ERYTHROMYCIN; ETOPOSIDE; GLYCOPROTEIN P; IMATINIB; IMMUNOMODULATING AGENT; INDINAVIR; ITRACONAZOLE; KETOCONAZOLE; MEFLOQUINE; MULTIDRUG RESISTANCE PROTEIN; NELFINAVIR; PACLITAXEL; RIFAMPICIN; RITONAVIR; SAQUINAVIR; TETRACYCLINE; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE;

BLOOD BRAIN BARRIER; BLOOD TESTIS BARRIER; CELL MEMBRANE TRANSPORT; ENZYME ACTIVITY; GENETIC POLYMORPHISM; HUMAN; MULTIDRUG RESISTANCE; SHORT SURVEY; ANIMAL; ARTICLE; DRUG INTERACTION; DRUG RESISTANCE; GENETIC VARIABILITY; GENETICS; PHARMACOGENETICS;

ANIMALS; DRUG INTERACTIONS; DRUG RESISTANCE; DRUG RESISTANCE, NEOPLASM; HUMANS; P-GLYCOPROTEIN; PHARMACOGENETICS; POLYMORPHISM, GENETIC; VARIATION (GENETICS);

EID: 14644421621     PISSN: 00292001     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (11)

1. www.gene.ucl.ac.uk/nomenclature/genfamily/abc.html (8.10.2003).
2. Marzolini C, Paus E, Buclin T et al. Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther 2004; 75: 13-33.
3. Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 1976; 455: 152-62.
4. Thomas H, Coley HM. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 2003; 10: 159-65.
5. Sakaeda T, Takara K, Kakumoto M et al. Simvastatin and lovastatin, but not pravastatin, interact with MDR1. J Pharm Pharmacol 2002; 54: 419-23.
6. Emi Y, Tsunashima D, Ogawara K et al. Role of P-glycoprotein as a secretory mechanism in quinidine absorption from rat small intestine. J Pharm Sci 1998; 87: 295-9.
7. Zhang Y, Benet LZ. The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein. Clin Pharmacokinet 2001; 40: 159-68.
8. Kroetz DL, Pauli-Magnus C, Hodges LM et al. Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics 2003; 13: 481-94.
9. Lin JH. Drug-drug interaction mediated by inhibition and induction of P-glycoprotein. Adv Drug Deliv Rev 2003; 55: 53-81.
10. Fromm MF. P-glycoprotein: a defense mechanism limiting oral bioavailabitity and CNS accumulation of drugs. Int J Clin Pharmacol Ther 2000; 38: 69-74.
11. Drozdzik M, Bialecka M, Honczarenko K et al. Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease. Pharmacogenetics 2003; 13: 259-63.