Review article: Oral ulcers and its relevance to systemic disorders

Alimentary Pharmacology and Therapeutics

Volumn 21, Issue 4, 2005, Pages 295-306

  Porter, S R ^a   Leao, J C ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIMALARIAL AGENT; ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; BARBITURIC ACID DERIVATIVE; BENZYDAMINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBAMAZEPINE; CHLORHEXIDINE GLUCONATE; CORTICOSTEROID; CYTOTOXIC AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FAMCICLOVIR; FOSCARNET; GANCICLOVIR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOSUPPRESSIVE AGENT; INTERFERON; METRONIDAZOLE; NONSTEROID ANTIINFLAMMATORY AGENT; PENCICLOVIR; PENICILLAMINE; PENICILLIN V; PROTEGRIN; RIFAMPICIN; SCLEROSING AGENT; SULFONAMIDE; THALIDOMIDE; UNINDEXED DRUG; VALACICLOVIR;

ANEMIA; CLINICAL FEATURE; CLINICAL TRIAL; CYTOMEGALOVIRUS; DISEASE PREDISPOSITION; EPSTEIN BARR VIRUS; ERYTHEMA MULTIFORME; GASTROINTESTINAL DISEASE; HERPES; HERPES SIMPLEX VIRUS 1; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; IMMUNE DEFICIENCY; INJURY; KAPOSI SARCOMA; LICHENOID ERUPTION; LUPUS VULGARIS; MALIGNANT NEOPLASTIC DISEASE; MOUTH ULCER; MUCOSA INFLAMMATION; MYCOBACTERIOSIS; MYCOSIS; NEUTROPENIA; NONHODGKIN LYMPHOMA; PATHOGENESIS; PEMPHIGOID; PEMPHIGUS; PRIORITY JOURNAL; REVIEW; SALIVARY GLAND DISEASE; SIDE EFFECT; SKIN DISEASE; TOOTH COLOR; TREPONEMA PALLIDUM; VINCENT STOMATITIS;

BACTERIAL INFECTIONS; GASTROINTESTINAL DISEASES; HIV INFECTIONS; HUMANS; NEOPLASMS; ORAL ULCER; SKIN DISEASES; STOMATITIS, HERPETIC;

EID: 14644414172     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2005.02333.x     Document Type: Review

References (83)

1. Dellinger TM, Livingston HM. Aspirin burn of the oral cavity. Ann Pharmacother 1998; 32: 1107.
2. Parry J, Porter S, Scully C, Flint S, Parry MG. Mucosal lesions due to oral cocaine use. Br Dent J 1996; 180: 462-4.
3. Lancaster J, Belloso A, Wilson CA, McCormick M. Rare case of naso-oral fistula with extensive osteocartilaginous necrosis secondary to cocaine abuse: review of otorhinolaryngological presentations in cocaine addicts. J Laryngol Otol 2000; 114: 630-3.
4. Scully C, Epstein J, Sonis S. Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: Part 2. diagnosis and management of mucositis. Head Neck 2004; 26: 77-84.
5. Potten CS, Booth D, Cragg NJ, et al. Cell kinetic studies in the murine ventral tongue epithelium: mucositis induced by radiation and its protection by pretreatment with keratinocyte growth factor (KGF). Cell Prolif 2002; 35 (Suppl. 1): 32-47.
6. Stokman MA, Spijkervet FK, Burlage FR, et al. Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial. Br J Cancer 2003; 88: 1012-6.
7. Mantovani G, Massa E, Astara G, et al. Phase II clinical trial of local use of GM-CSF for prevention and treatment of chemotherapy- and concomitant chemoradiotherapy-induced severe oral mucositis in advanced head and neck cancer patients: an evaluation of effectiveness, safety and costs. Oncol Rep 2003; 10: 197-206.
8. Chen J, Falla TJ, Liu H, et al. Development of protegrins for the treatment and prevention of oral mucositis: structure-activity relationships of synthetic protegrin analogues. Biopolymers 2000; 55: 88-98.
9. Koscielny S, Raabe G. Necrotizing sialometapiasia - a specific differential diagnosis of an ulcer of the hard palate. Laryngorhinootologie 2003; 82: 568-72.
10. Schoning H, Emshoff R, Kreczy A. Necrotizing sialometaplasia in two patients with bulimia and chronic vomiting. Int J Oral Maxillofac Surg 1998; 27: 463-5.
11. Lafferty WE. The changing epidemiology of HSV-1 and HSV-2 and implications for serological testing. Herpes 2002; 9: 51-5.
12. Piluso S, Ficarra G, Lucatorto FM, et al. Cause of oral ulcers in HIV-infected patients: a study of 19 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 82: 166-72.
13. Kleymann G. Novel agents and strategies to treat herpes simplex virus infections. Expert Opin Investig Drugs 2003; 12: 165-83.
14. Villarreal EC. Current and potential therapies for the treatment of herpes-virus infections. Prog Drug Res 2003; 60: 263-307.
15. Gilquin J, Weiss L, Kazatchkine MD. Genital and oral erosions induced by foscarnet. Lancet 1990; 335: 287.
16. Spruance SL, Nett R, Marbury T, Wolff R, Johnson J, Spaulding T. Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials. Antimicrob Agents Chemother 2002; 46: 2238-43.
17. Sarisky RT, Bacon T, Boon R, et al. Penciclovir susceptibilities of herpes simplex virus isolates from patients using penciclovir cream for treatment of recurrent herpes labialis. Antimicrob Agents Chemother 2002; 46: 2848-53.
18. Kokuba H, Imafuku S, Huang S, Aurelian L, Burnett JW. Erythema multiforme lesions are associated with expression of a herpes simplex virus (HSV) gene and qualitative alterations in the HSV-specific T-cell response. Br J Dermatol 1998; 138: 952-64.
19. Szczepanski T, De Vaan GA, Beishuizen A, et al. Acute lymphoblastic leukemia followed by a clonally-unrelated EBV-positive non-Hodgkin lymphoma and a clonally-related myelomonocytic leukemia cutis. Pediatr Blood Cancer 2004; 42: 343-9.
20. Fluckiger R, Laifer G, Itin P, Meyer B, Lang C. Oral hairy leukoplakia in a patient with ulcerative colitis. Gastroenterology 1994; 106: 506-8.
21. Kanas RJ, Jensen JL, Abrams AM, Wuerker RB. Oral mucosal cytomegalovirus as a manifestation of the acquired immune deficiency syndrome. Oral Surg Oral Med Oral Pathol 1987; 64: 183-9.
22. Flaitz CM, Nichols CM, Hicks MJ. Herpesviridae-associated persistent mucocutaneous ulcers in acquired immunodeficiency syndrome. A clinicopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 81: 433-41.
23. Lager I, Altini M, Coleman H, Ali H. Oral Kaposi's sarcoma: a clinicopathologic study from South Africa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 96: 701-10.
24. Reichart PA, Schiodt M. Non-pigmented oral Kaposi's sarcoma (AIDS). Report of two cases. Int J Oral Maxillofac Surg 1989; 18: 197-9.
25. Diz DP, Ocampo HA, Miralles AC, Vazquez GE, Martinez VC. Regression of AIDS-related Kaposi's sarcoma following ritonavir therapy. Oral Oncol 1998; 34: 236-8.
26. Le Bourgeois JP, Frikha H, Piedbois P, Le Pechoux C, Martin L, Haddad E. Radiotherapy in the management of epidemic Kaposi's sarcoma of the oral cavity, the eyelid and the genitals. Radiother Oncol 1994; 30: 263-6.
27. Ramirez-Amador V, Esquivel-Pedraza L, Lozada-Nur F, et al. Intralesional vinblastine vs. 3% sodium tetradecyl sulfate for the treatment of oral Kaposi's sarcoma. A double blind, randomized clinical trial. Oral Oncol 2002; 38: 460-7.
28. Scully C, Laskaris G, Pindborg J, Porter SR, Reichart P. Oral manifestations of HIV infection and their management: II. Less common lesions. Oral Surg Oral Med Oral Pathol 1991; 71: 167-71.
29. Scully C, Laskaris G, Pindborg J, Porter SR, Reichart P. Oral manifestations of HIV infection and their management: I. More common lesions. Oral Surg Oral Med Oral Pathol 1991; 71: 158-66.
30. MacPhail LA, Greenspan JS. Oral ulceration in HIV infection: investigation and pathogenesis. Oral Dis 1997; 3 (Suppl. 1): S190-3.
31. Di Alberti L, Porter SR, Speight PM, et al. Detection of human herpesvirus-8 DNA in oral ulcer tissues of HIV-infected individuals. Oral Dis 1997; 3 (Suppl. 1): S133-4.
32. Ramirez-Amador VA, Esquivel-Pedraza L, Ponce-de-Leon S, et al. Thalidomide as therapy for human immunodeficiency virus-related oral ulcers: a double-blind placebo-controlled clinical trial. Clin Infect Dis 1999; 28: 892-4.
33. Ficarra G. Oral ulcers in HIV-infected patients: an update on epidemiology and diagnosis. Oral Dis 1997; 3 (Suppl. 1): S183-9.
34. Novak MJ. Necrotizing ulcerative periodontitis. Ann Periodontol 1999; 4: 74-8.
35. Enwonwu CO, Falkler WA Jr, Idigbe EO, et al. Pathogenesis of cancrum oris (noma): confounding interactions of malnutrition with infection. Am J Trop Med Hyg 1999; 60: 223-32.
36. Jones AC, Gulley ML, Freedman PD. Necrotizing ulcerative stomatitis in human immunodeficiency virus-seropositive individuals: a review of the histopathologic, immunohistochemical, and virologic characteristics of 18 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000; 89: 323-32.
37. Adekeye EO, Ord RA. Cancrum oris: principles of management and reconstructive surgery. J Maxillofac Surg 1983; 11: 160-70.
38. Alam F, Argiriadou AS, Hodgson TA, Kumar N, Porter SR. Primary syphilis remains a cause of oral ulceration. Br Dent J 2000; 189: 352-4.
39. Steiner M, Alexander WN. Primary syphilis of the gingiva. Report of two cases. Oral Surg Oral Med Oral Pathol 1966; 21: 530-5.
40. Brown DL, Frank JE. Diagnosis and management of syphilis. Am Fam Physician 2003; 68: 283-90.
41. Iype EM, Ramdas K, Pandey M, et al. Primary tuberculosis of the tongue: report of three cases. Br J Oral Maxillofac Surg 2001; 39: 402-3.
42. Ilyas SE, Chen FF, Hodgson TA, et al. Labial tuberculosis: a unique cause of lip swelling complicating HIV infection. HIV Med 2002; 3: 283-6.
43. Myoken Y, Sugata T, Kyo TI, Fujihara M. Pathological features of invasive oral aspergillosis in patients with hematologic malignancies. J Oral Maxillofac Surg 1996; 54: 263-70.
44. Loh FC, Yeo JF, Tan WC, Kumarasinghe G. Histoplasmosis presenting as hyperplastic gingival lesion. J Oral Pathol Med 1989; 18: 533-6.
45. Scully C, de Almeida OP. Orofacial manifestations of the systemic mycoses. J Oral Pathol Med 1992; 21: 289-94.
46. Moraru RA, Grossman ME. Palatal necrosis in an AIDS patient: a case of mucormycosis. Cutis 2000; 66: 15-8.
47. Porter SR, Scully C, Pedersen A. Recurrent aphthous stomatitis. Crit Rev Oral Biol Med 1998; 9: 306-21.
48. Srinivasan U, Weir DG, Feighery C, O'Farrelly C. Emergence of classic enteropathy after longstanding gluten sensitive oral ulceration. BMJ 1998; 316: 206-7.
49. Porter SR, Barker GR, Scully C, Macfarlane G, Bain L. Serum IgG antibodies to Helicobacter pylori in patients with recurrent aphthous stomatitis and other oral disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 83: 325-8.
50. Porter S, Scully C. Aphthous ulcers: recurrent. Clin Evid 2002; 8: 1397-403.
51. Hunter L, Addy M. Chlorhexidine gluconate mouthwash in the management of minor aphthous ulceration. A double-blind, placebo-controlled cross-over trial. Br Dent J 1987; 162; 106-10.
52. Barrons RW. Treatment strategies for recurrent oral aphthous ulcers. Am J Health Syst Pharm 2001; 58: 41-50.
53. MacPhail L. Topical and systemic therapy for recurrent aphthous stomatitis. Semin Cutan Med Surg 1997; 16: 301-7.
54. Eisen D, Lynch DP. Selecting topical and systemic agents for recurrent aphthous stomatitis. Cutis 2001; 68: 201-6.
55. Shetty K. Thalidomide for recurrent aphthous ulcerations. HIV Clin 2003; 15: 4-6.
56. Arayssi T, Hamdan A. New insights into the pathogenesis and therapy of Behcet's disease. Curr Opin Pharmacol 2004; 4: 183-8.
57. Femiano F, Gombos F, Scully C. Sweet's syndrome: recurrent oral ulceration, pyrexia, thrombophlebitis, and cutaneous lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 95: 324-7.
58. Feder HM Jr. Periodic fever, aphthous stomatitis, pharyngitis, adenitis: a clinical review of a new syndrome. Curr Opin Pediatr 2000; 12: 253-6.
59. Nowak M, Dziechciarz P, Dwilewicz-Trojaczek J. The frequency of coeliac disease occurrence in patients with recurrent aphthous stomatitis (RAS) - preliminary report. Wiad Lek 2002; 55: 542-6.
60. O'Regan E, Bane A, Flint S, Timon C, Toner M. Linear IgA disease presenting as desquamative gingivitis: a pattern poorly recognized in medicine. Arch Otolaryngol Head Neck Surg 2004; 130: 469-72.
61. Rehberger A, Puspok A, Stallmeister T, Jurecka W, Wolf K. Crohn's disease masquerading as aphthous ulcers. Eur J Dermatol 1998; 8: 274-6.
62. Bogenrieder T, Rogler G, Vogt T, Landthaler M, Stolz W. Orofacial granulomatosis as the initial presentation of Crohn's disease in an adolescent. Dermatology 2003; 206: 273-8.
63. Girlich C, Bogenrieder T, Palitzsch KD, Scholmerich J, Lock G. Orofacial granulomatosis as initial manifestation of Crohn's disease: a report of two cases. Eur J Gastroenterol Hepatol 2002; 14: 873-6.
64. Bishop RP, Brewster AC, Antonioli DA. Crohn's disease of the mouth. Gastroenterology 1972; 62: 302-6.
65. Tyldesley WR. Oral Crohn's disease and related conditions. Br J Oral Surg 1979; 17: 1-9.
66. Gibson J, Neilly JB, Wray AP, Evans TJ, MacKenzie JR, McKillop JH. [99Tcm]-HMPAO leucocyte labelling in orofacial granulomatosis and gastrointestinal Crohn's disease in childhood and early adulthood. Nucl Med Commun 2000; 21: 155-8.
67. Ficarra G, Cicchi P, Amorosi A. Piluso S. Oral Crohn's disease and pyostomatitis vegetans. An unusual association. Oral Surg Oral Med Oral Pathol 1993; 75: 220-4.
68. Hernandez-Martin A, Arias-Palomo D, Hermida G, et al. Oral pyoderma gangrenosum. Br J Dermatol 2003; 149: 663-4.
69. Lackey MA, Barth J. Gastroesophageal reflux disease: a dental concern. Gen Dent 2003; 51: 250-4.
70. Scully C, Beyli M, Ferreiro MC, et al. Update on oral lichen planus: etiopathogenesis and management. Crit Rev Oral Biol Med 1998; 9: 86-122.
71. McCartan BE, McCreary CE. Oral lichenoid drug eruptions. Oral Dis 1997; 3: 58-63.
72. Bratel J, Dahlgren U, Simark MC, Jontell M. The frequency of different T-cell receptor V-families in oral lichen planus and lichenoid contact lesions: an immunohistochemical study. J Oral Pathol Med 1998; 27: 415-9.
73. Nagao Y, Sata M, Ide T, et al. Development and exacerbation of oral lichen planus during and after interferon therapy for hepatitis C. Eur J Clin Invest 1996; 26: 1171-4.
74. Hegarty AM, Hodgson TA, Lewsey P, Porter SR. Fluticasone propionate spray and betamethasone sodium phosphate mouthrinse: a randomized crossover study for the treatment of symptomatic oral lichen planus. J Am Acad Dermatol 2002; 47: 271-9.
75. Kaliakatsou F, Hodgson TA, Lewsey JD, Hegarty AM, Murphy AG, Porter SR. Management of recalcitrant ulcerative oral lichen planus with topical tacrolimus. J Am Acad Dermatol 2002; 46: 35-41.
76. Porter SR, Scully C, Eveson JW. The efficacy of topical cyclosporin in the management of desquamative gingivitis due to lichen planus. Br J Dermatol 1993; 129: 753-5.
77. Rodstrom PO, Jontell M, Mattsson U, Holmberg E. Cancer and oral lichen planus in a Swedish population. Oral Oncol 2004; 40: 131-8.
78. Silverman S, Bhargava K, Smith LW, Malaowalla AM. Malignant transformation and natural history of oral leukoplakia in 57,518 industrial workers of Gujarat, India. Cancer 1976; 38: 1790-5.
79. Gupta PC, Mehta FS, Pindborg JJ, et al. Intervention study for primary prevention of oral cancer among 36000 Indian tobacco users. Lancet 1986; 1: 1235-9.
80. Rajkumar T, Sridhar H, Balaram P, et al. Oral cancer in Southern India: the influence of body size, diet, infections and sexual practices. Eur J Cancer Prev 2003; 12: 135-43.
81. Porter S, Scully C. HIV: the surgeon's perspective: Part 3. Diagnosis and management of malignant neoplasms. Br J Oral Maxillofac Surg 1994; 32: 241-7.
82. Lippman SM, Grogan TM, Spier CM, et al. Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma. Cancer 1987; 59: 936-9.
83. Scully C, Bagan JV. Adverse drug reactions in the orofacial region. Crit Rev Oral Biol Med 2004; 15: 221-39.