Effects of Ginkgo biloba on exhaled nasal nitric oxide during normobaric hypoxia in humans

High Altitude Medicine and Biology

Volumn 5, Issue 4, 2004, Pages 445-449

  Jowers, Casey ^a   Shih, Richard ^a   James, Jim ^a   Deloughery, Thomas G ^a   Holden, William E ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Acute mountain sickness; Altitude; High altitude pulmonary edema; Nose; Vasodilation

Indexed keywords

GINKGO BILOBA EXTRACT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYHEMOGLOBIN; TRUNATURE;

ADULT; ALTITUDE DISEASE; ARTERIAL OXYGEN SATURATION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; EXHALATION; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LUNG MINUTE VOLUME; MALE; NORMAL HUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; VASODILATATION;

ADULT; ALTITUDE; ALTITUDE SICKNESS; EXHALATION; FEMALE; GINKGO BILOBA; HEART RATE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; OXYGEN CONSUMPTION; PHYTOTHERAPY; PLANT EXTRACTS; RESPIRATION; TIME FACTORS; VASODILATOR AGENTS;

EID: 14644395608     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2004.5.445     Document Type: Article

References (12)

1. Basnyat B., and Murdoch, D.R. (2003). High-altitude illness. Lancet 361:1967-1974.
2. Beall C.M., et al. (2001). Pulmonary nitric oxide in mountain dwellers. Nature 414:411-412.
3. Cheung F., et al. (1999). Inhibitory effect of Ginkgo biloba extract on the expression of inducible nitric oxide synthase in endothelial cells. Biochem. Pharmacol. 58:1665-1673.
4. Gertsch J.H., et al. (2002). Ginkgo biloba for the prevention of severe acute mountain sickness (AMS) starting one day before rapid ascent. High Alt. Med. Biol. 3:29-37.
5. Kimberly B., et al. (1996). Nasal contribution to exhaled nitric oxide at rest and during breathholding in humans. Am. J. Respir. Crit. Care Med. 153:829-836.
6. Kubota Y., et al. (2001). Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level. Life Sci. 69:2327-2336.
7. Lundberg J.O., et al. (1995). High nitric oxide production in human paranasal sinuses. Nat. Med. 1:370-373.
8. Mangus R.S., et al. (1997). Effects of hypoxia on nasal and total respiratory tract release of nitric oxide. Am. J. Resp. Crit. Care Med. 155:A241.
9. Mansoor J., et al. (2002). Effect of L-arginine supplementation on expired NO and respiratory symptomology with acute exposure to an altitude of 4383 meters. High Alt. Med. Biol. 3:445.
10. Roncin J.P., et al. (1996). EGb 761 in control of acute mountain sickness and vascular reactivity to cold exposure. Aviat. Space Environ. Med. 67:445-452.
11. Schilling L., and M. Wahl (1999). Mediators of cerebral edema. Adv. Exp. Biol. Med. 464:123-141.
12. Van Mil A.H., et al. (2002). Nitric oxide mediates hypoxia-induced cerebral vasodilation in humans. J. Appl. Physiol. 92:962-966.