Osteopontin expression in proliferated bile ductules: The correlation with liver damage in fulminant hepatitis

Digestive Diseases and Sciences

Volumn 50, Issue 1, 2005, Pages 188-195

  Tajiri, Takuma ^a   Tate, Genshu ^a   Kunimura, Toshiaki ^b   Endo, Yutaka ^a   Inoue, Kazuaki ^a   Mitsuya, Toshiyuki ^a   Morohoshi, Toshio ^b   Yoshiba, Makoto ^a  

^a SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Clinical forms; Fulminant hepatitis; Osteopontin; Proliferated bile ductules

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CELL NUCLEUS ANTIGEN; OSTEOPONTIN; BIOLOGICAL MARKER; CYCLINE; SIALOGLYCOPROTEIN; SPP1 PROTEIN, HUMAN;

ADULT; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOPSY; BILE DUCT; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEPATITIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER FAILURE; LIVER INJURY; MALE; MICROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; ACUTE DISEASE; AGED; BLOOD; CASE CONTROL STUDY; LIVER; METABOLISM; MIDDLE AGED; NECROSIS; PATHOLOGY;

ACUTE DISEASE; ADULT; AGED; ASPARTATE AMINOTRANSFERASES; BILE DUCTS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; HEPATITIS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER FAILURE, ACUTE; MALE; MIDDLE AGED; NECROSIS; OSTEOPONTIN; PROLIFERATING CELL NUCLEAR ANTIGEN; SIALOGLYCOPROTEINS;

EID: 14544303684     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-1299-4     Document Type: Article

References (31)

1. Sato S, Suzuki S, Takikawa Y: Prospective study to clarify the prognosis of patients with acute hepatitis severe type and fulminant hepatitis in Japan. Annual report 1998. Intractable Liver Diseases Study Group of Japan, Ministry of Health and Welfare. Annual Report 1999, pp. 67-69
2. Yoshiba M, Sekiyama K, Iwamura Y, Sugata F: Development of reliable artificial liver support (ALS)-plasma exchange in combination with hemodiafiltration using high-performance membrane. Dig Dis Sci 38:469-476, 1993
3. Streetz K, Leifeld L, Grundmann D, Grundmann D, Ramakers J, Eckert K, Spengler U, Brenner D, Manns M, Trautwein C: Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Gastroenterology 18:446-160, 2000
4. Eguchi S, Kamlot A, Ljubimova J, Hewitt WR, Lebow LT, Demetriou AA, Rozga J: Fulminant hepatic failure in rats: survival effect on blood chemistry and liver regeneration. Hepatology 24:1452-1459, 1996
5. Kunimura T, Ooike N, Sasajima Y, Ishikawa Y, Inagaki T, Morhoshi T: Subsequent loss of the proliferated bile ductules in fulminant hepatitis in childhood - Isn't it causedby apoptosis? Am J Gastroenterol 96:1299-1300, 2001
6. Bhathal PS, Gall JA: Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus. Liver 5:311-325, 1985
7. Thung SN: The development of proliferating ductular structures in liver disease. An immunohistochemical study. Arch Pathol Lab Med 114:407-411, 1990
8. Harada K, Ozaki S, Sudo Y, Tsuneyama K, Ohta H, Nakanuma Y: Osteopontin is involved in the formation of epithelioid granuloma and bile duct injury in primary biliary cirrhosis. Pathol Int 53:8-17, 2003
9. Ashkar S, Weber GF, Panoutsakopoulou V, Sanchirico ME, Jansson M, Zawaideh S, Rittling SR Denhardt DT, Glimcher MJ, Cantor H: Eta-1 (Osteopontin): an early component of type-1 (cell-mediated) immunity. Science 287:860-864, 2000
10. Murray CE, Giachelli CM, Schwartz SM, Giachelli CM, Schwartz SM, Vracko R: Macrophages express osteopontin during repair of myocardial necrosis. Am J Pathol 145:1450-1462, 1994
11. Brown LF, Papadapoulos-Sergiou AP, Berse B, Manseau EJ, Tognazzi K, Perruzi CA, Dvorak HF, Senger DR: Osteopontin expression and distribution in human carcinomas. Am J Pathol 145:610-623, 1994
12. Carlson I, Tognazzi K, Manseau EJ, Dvorak HF, Brown LF: Osteopontin is strongly expressed by histiocytes in granulomas of diverse etiology. Lab Invest 77:103-108, 1997
13. Guo H, Cai CQ, Schroeder RA, Kuo PC: Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages. J Immunol 166:1079-1086, 2001
14. Mochida S, Fujiwara K: Symposium on clinical aspects in hepatitis virus infection. 2. Recent advances and fulminant hepatitis in Japan. Intern Med 40:175-177, 2001
15. Takahashi Y, Shimizu M: Aetiology and prognosis of fulminant viral hepatitis in Japan: a multicentre study. The Study Group of Fulminant Hepatitis. J. Gastroenterol Hepatol 6:159-164, 1991
16. Gimson AE, O'Grady J, Ede RJ, Portmann D, Williams R: Late onset hepatic failure: clinical, serological and histological features. Hepatology 6:288-294, 1986
17. Shimizu M, Takahashi Z, Tomita E, Mutoh Y, Takahashi M, Ojima S: Histopathological findings in fulminant hepatitis. 12th Shininuyama Symposium Record Company, 1981, pp. 137-143 (in Japanese)
18. New liver pathology, Shin-inuyama Symposium. Tokyo, Japan Chuugaisya, 1999, pp. 54-55 (in Japanese)
19. Missale G, Redeker A, Person J, Fowler P, Guilhot S, Schlicht HJ, Ferrari C, Chisari FV: HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis. J Exp Med 177:751-762, 1993
20. Naito M, Takahashi K, Nishikawa S: Development, differentiation, and maturation of macrophages in the fetal mouse liver. J Leukoc Biol 48:27-37, 1990
21. Arai M, Mochida S, Ohno A, Ogata I, Fujiwara K: Sinusoidal endothelial cell damage by activated macrophages in rat liver necrosis. Gastroenterology 104:1466-1471, 1993
22. Uchida T, Peters RL: The nature and origin of proliferated bile ductules in alcoholic liver disease. Am J Clin Pathol 79:326-333, 1983
23. Grisham JW, Thorgeirsson SS: Liver stem cells. In Stem Cells. San Diego, Academic Press, 1997, pp. 233-282
24. Wolf HK, Michalopoulos GK: Hepatocyte regeneration in acute fulminant hepatitis and non fulminant hepatitis: a study of proliferating cell nuclear antigen expression. Hepatology 15:707-713, 1992
25. Demetris AJ, Seaberg EC, Wennerberg A, Lonellie J, Michalopoulos G: Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes. Am J Pathol 149:439-448, 1996
26. Johnson M, Koukoulis G, Matsumoto K, Nakamura T, Iyer A: Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells. Hepatology 17:1052-1061, 1993
27. Wang Y, Mochida S, Kawashima R, Inao M, Matsui A, Youlutuz Y, Nagoshi S, Uede T, Fujiwara K: Increased expression of osteopontin in activated Kupffer cells and hepatic macrophages during macrophage migration in Propionibacterium acnes-treated rat liver. J Gastroenterol 35:696-701, 2000
28. Kawashima R, Mochida S, Matsui A, et al.: Expression of osteopontin in Kupffer cells and hepatic macrophages and Stellate cells in rat liver after carbon tetrachloride intoxication: a possible factor for macrophage migration into hepatic necrotic areas. Biochem Biophys Res Commun 256:527-531, 1999
29. Gotoh M, Sakamoto M, Kanetaka K, Chuuma M, Hirohashi S: Overexpression of osteopontin in hepatocellular carcinoma. Pathol Int 52:19-24, 2002
30. Inoue K, Yoshiba M, Sekiyama K, Okamoto H, Mayumi M: Clinical and molecular virological differences between fulminant hepatic failures following acute and chronic infection with hepatitis B virus. J Med Virol 55:35-41, 1998
31. Mochida S, Fujiwara K: Fulminant hepatitis and late onset hepatic failure (LOHF) in Japan. Jpn J Gastroenterol 99:895-904, 2002 (in Japanese)