메뉴 건너뛰기




Volumn 18, Issue 2 SPEC. ISS., 2005, Pages 299-317

Deferiprone therapy for transfusional iron overload

Author keywords

Deferiprone; Desferrioxamine; Iron chelation; Iron overload; Thalassaemia major

Indexed keywords

ALANINE AMINOTRANSFERASE; DEFERIPRONE; DEFEROXAMINE; FERRITIN; LIVER ENZYME;

EID: 14544288577     PISSN: 15216926     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beha.2004.08.026     Document Type: Review
Times cited : (54)

References (68)
  • 2
    • 0036428802 scopus 로고    scopus 로고
    • Oral iron chelators - Development and application
    • D.Y. Liu Z.D. Liu R.C. Hider Oral iron chelators - development and application Clinical Haematology 15 2002 369-384
    • (2002) Clinical Haematology , vol.15 , pp. 369-384
    • Liu, D.Y.1    Liu, Z.D.2    Hider, R.C.3
  • 3
    • 14544284914 scopus 로고
    • Prospects for effective and oral chelation in transfusional iron overload
    • G.J. Kontoghiorghes A.V. Hoffbrand Prospects for effective and oral chelation in transfusional iron overload Recent Advances in Haematology 5 1988 75-98
    • (1988) Recent Advances in Haematology , vol.5 , pp. 75-98
    • Kontoghiorghes, G.J.1    Hoffbrand, A.V.2
  • 5
    • 0023214937 scopus 로고
    • 1-2-dimethyl-3-hydroxypyrid-4-one an orally active chelator for treatment of iron overload
    • G.J. Kontoghiorges M.A. Aldouri L. Sheppard et al. 1-2-dimethyl-3-hydroxypyrid-4-one an orally active chelator for treatment of iron overload Lancet i 1987 1294-1295
    • (1987) Lancet , vol.1 , pp. 1294-1295
    • Kontoghiorges, G.J.1    Aldouri, M.A.2    Sheppard, L.3
  • 6
    • 0023489829 scopus 로고
    • Effective chelation of iron in beta thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one
    • G.J. Kontoghiorges M.A. Aldouri A.V. Hoffbrand et al. Effective chelation of iron in beta thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one British Medical Journal 295 1987 1509-1512
    • (1987) British Medical Journal , vol.295 , pp. 1509-1512
    • Kontoghiorges, G.J.1    Aldouri, M.A.2    Hoffbrand, A.V.3
  • 7
    • 0032887235 scopus 로고    scopus 로고
    • Deferiprone: A review of its clinical potential in iron overload in alpha thalassaemia major and other transfusion-dependent diseases
    • J.A. Barman Balfour R.H. Foster Deferiprone: A review of its clinical potential in iron overload in alpha thalassaemia major and other transfusion-dependent diseases Drugs 3 1999 553-578
    • (1999) Drugs , vol.3 , pp. 553-578
    • Barman Balfour, J.A.1    Foster, R.H.2
  • 8
    • 0037630378 scopus 로고    scopus 로고
    • Role of deferiprone in chelation therapy for transfusional iron overload
    • A.V. Hoffbrand A. Cohen C. Hershko Role of deferiprone in chelation therapy for transfusional iron overload Blood 102 2003 17-24
    • (2003) Blood , vol.102 , pp. 17-24
    • Hoffbrand, A.V.1    Cohen, A.2    Hershko, C.3
  • 10
    • 0026001164 scopus 로고
    • Relationship between the pharmacokinetics and iron excretion pharmacodynamics of the new oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one in patients with thalassemia
    • D. Matsui J. Klein C. Hermann et al. Relationship between the pharmacokinetics and iron excretion pharmacodynamics of the new oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one in patients with thalassemia Clinical and Pharmacological Therapeutics 50 1991 294-298
    • (1991) Clinical and Pharmacological Therapeutics , vol.50 , pp. 294-298
    • Matsui, D.1    Klein, J.2    Hermann, C.3
  • 11
    • 0028962119 scopus 로고
    • Pharmacokinetics of the oral chelator deferiprone (L1) in patients with iron overload
    • F.N. Al-Refaie L.N. Shephard P. Nortey et al. Pharmacokinetics of the oral chelator deferiprone (L1) in patients with iron overload British Journal of Haematology 89 1995 403-408
    • (1995) British Journal of Haematology , vol.89 , pp. 403-408
    • Al-Refaie, F.N.1    Shephard, L.N.2    Nortey, P.3
  • 12
    • 0028345040 scopus 로고
    • Iron-balance and dose-response studies of the oral irn chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in iron-loaded patients with sickle cell disease
    • A.F. Collins F.F. Fassos S. Stobie et al. Iron-balance and dose-response studies of the oral irn chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in iron-loaded patients with sickle cell disease Blood 83 1994 2329-2333
    • (1994) Blood , vol.83 , pp. 2329-2333
    • Collins, A.F.1    Fassos, F.F.2    Stobie, S.3
  • 13
    • 0038099031 scopus 로고    scopus 로고
    • Iron chelation therapy: Metabolic aspects of combining deferiprone and deferoxamine
    • (abstract). 11th International Conference on Oral Chelation in the Treatment of Thalassaemia Major and Other Diseases
    • R.W. Grady V. Berdoukas E.A. Rachmilewitz et al. Iron chelation therapy: metabolic aspects of combining deferiprone and deferoxamine (abstract). 11th International Conference on Oral Chelation in the Treatment of Thalassaemia Major and Other Diseases Catania 2001 74-78
    • (2001) Catania , pp. 74-78
    • Grady, R.W.1    Berdoukas, V.2    Rachmilewitz, E.A.3
  • 14
    • 0038438059 scopus 로고    scopus 로고
    • Combinations of desferrioxamine and deferiprone markedly enhance iron excretion
    • (abstract)
    • R.W. Grady V. Berdoukas E.A. Rachmilewitz et al. Combinations of desferrioxamine and deferiprone markedly enhance iron excretion (abstract) Blood 100 2002 241
    • (2002) Blood , vol.100 , pp. 241
    • Grady, R.W.1    Berdoukas, V.2    Rachmilewitz, E.A.3
  • 15
    • 0025018222 scopus 로고
    • Long-term trial with the oral iron chelator 1,2-dimethyl-s-hydroxypyrid-4-one (L1). I. Iron chelation and metabolic studies
    • G.J. Kontoghiorghes A.N. Bartlett A.V. Hoffbrand et al. Long-term trial with the oral iron chelator 1,2-dimethyl-s-hydroxypyrid-4-one (L1). I. Iron chelation and metabolic studies British Journal of Haematology 76 1990 295-300
    • (1990) British Journal of Haematology , vol.76 , pp. 295-300
    • Kontoghiorghes, G.J.1    Bartlett, A.N.2    Hoffbrand, A.V.3
  • 16
    • 0027486590 scopus 로고
    • Subcellular distribution of desferrioxamine and hydroxypyridin-4-one chelators in K562 cells affects dilution of intracellular iron pools
    • K.P. Hoyes J.B. Porter Subcellular distribution of desferrioxamine and hydroxypyridin-4-one chelators in K562 cells affects dilution of intracellular iron pools British Journal of Haematology 85 1993 393-400
    • (1993) British Journal of Haematology , vol.85 , pp. 393-400
    • Hoyes, K.P.1    Porter, J.B.2
  • 17
    • 0029097965 scopus 로고
    • Deferiprone (L1) chelates pathologic iron deposits from membranes of intact thalassaemic and sickle red blood cells from both in vitro and in vivo
    • O. Shalev T. Repka A. Goldfarb et al. Deferiprone (L1) chelates pathologic iron deposits from membranes of intact thalassaemic and sickle red blood cells from both in vitro and in vivo Blood 86 1995 2008-2013
    • (1995) Blood , vol.86 , pp. 2008-2013
    • Shalev, O.1    Repka, T.2    Goldfarb, A.3
  • 18
    • 0032896230 scopus 로고    scopus 로고
    • Deferiprone therapy in homozygous human beta-thalassemia removes erythrocyte membrane free iron and reduces KCl co-transport activity
    • L. de Franchesi O. Shalev A. Piga et al.Deferiprone therapy in homozygous human beta-thalassemia removes erythrocyte membrane free iron and reduces KCl co-transport activity Journal of Laboratory and Clinical Medicine 133 1999 64-69
    • (1999) Journal of Laboratory and Clinical Medicine , vol.133 , pp. 64-69
    • de Franchesi, L.1    Shalev, O.2    Piga, A.3
  • 19
    • 0038486942 scopus 로고    scopus 로고
    • Clinical trial of deferiprone iron chelation therapy in β-thalassaemia/haemoglobin E patients in Thailand
    • P. Pootrakul P. Sirankapracha J. Sankote et al. Clinical trial of deferiprone iron chelation therapy in β-thalassaemia/haemoglobin E patients in Thailand British Journal of Haematology 122 2003 305-310
    • (2003) British Journal of Haematology , vol.122 , pp. 305-310
    • Pootrakul, P.1    Sirankapracha, P.2    Sankote, J.3
  • 21
    • 0028898064 scopus 로고
    • Iron-chelation therapy with oral deferiprone in patients with thalassemia major
    • N.F. Olivieri G.M. Brittenham D. Matsui et al. Iron-chelation therapy with oral deferiprone in patients with thalassemia major New England Journal of Medicine 332 1995 918-922
    • (1995) New England Journal of Medicine , vol.332 , pp. 918-922
    • Olivieri, N.F.1    Brittenham, G.M.2    Matsui, D.3
  • 22
    • 0032514558 scopus 로고    scopus 로고
    • Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major
    • N.F. Olivieri G.M. Brittenham C.E. McLaren et al. Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major New England Journal of Medicine 339 1998 417-423
    • (1998) New England Journal of Medicine , vol.339 , pp. 417-423
    • Olivieri, N.F.1    Brittenham, G.M.2    McLaren, C.E.3
  • 23
    • 0037930751 scopus 로고    scopus 로고
    • Monitoring long-term efficacy of iron chelatio therapy by deferiprone and desferrioxamine in patients with β-thalassaemia major: Application of SQUID biomagnetic liver susceptometry
    • R. Fischer F. Largo P. Nielson et al. Monitoring long-term efficacy of iron chelatio therapy by deferiprone and desferrioxamine in patients with β-thalassaemia major: Application of SQUID biomagnetic liver susceptometry British Journal of Haematology 121 2003 938-948
    • (2003) British Journal of Haematology , vol.121 , pp. 938-948
    • Fischer, R.1    Largo, F.2    Nielson, P.3
  • 24
    • 18444390877 scopus 로고    scopus 로고
    • Deferiprone versus deferoxamine in patients with thalassemia major: A randomized clinical trial
    • A. Maggio G.D. D'Amico A. Morabito et al. Deferiprone versus deferoxamine in patients with thalassemia major: A randomized clinical trial Blood Cells, Molecules and Diseases 28 2002 196-208
    • (2002) Blood Cells, Molecules and Diseases , vol.28 , pp. 196-208
    • Maggio, A.1    D'Amico, G.D.2    Morabito, A.3
  • 25
    • 0037125595 scopus 로고    scopus 로고
    • Improved myocardial iron levels and ventricular function with oral deferiprone compared with subcutaneous desferrioxamine in thalassemia
    • L.J. Anderson N. Wonke E. Prescott et al. Improved myocardial iron levels and ventricular function with oral deferiprone compared with subcutaneous desferrioxamine in thalassemia Lancet 360 2002 516-520
    • (2002) Lancet , vol.360 , pp. 516-520
    • Anderson, L.J.1    Wonke, N.2    Prescott, E.3
  • 27
    • 0028059813 scopus 로고
    • Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major
    • G.M. Brittenham P.M. Griffith A.W. Nienhuis et al. Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major New England Journal of Medicine 331 1994 567-573
    • (1994) New England Journal of Medicine , vol.331 , pp. 567-573
    • Brittenham, G.M.1    Griffith, P.M.2    Nienhuis, A.W.3
  • 28
    • 0038481233 scopus 로고    scopus 로고
    • Evaluation of myocardial iron by magnetic resonance imaging during iron chelation therapy with desferrioxamine: Indication of close relation between myocardial iron content and chelatable iron pool
    • P.D. Jensen F.T. Jenset T. Christensen et al. Evaluation of myocardial iron by magnetic resonance imaging during iron chelation therapy with desferrioxamine: Indication of close relation between myocardial iron content and chelatable iron pool Blood 101 2003 4632-4639
    • (2003) Blood , vol.101 , pp. 4632-4639
    • Jensen, P.D.1    Jenset, F.T.2    Christensen, T.3
  • 29
    • 18044399191 scopus 로고    scopus 로고
    • Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload
    • L. Anderson S. Holden B. Boris et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload European Heart Journal 22 2001 2171-2179
    • (2001) European Heart Journal , vol.22 , pp. 2171-2179
    • Anderson, L.1    Holden, S.2    Boris, B.3
  • 30
    • 0037505079 scopus 로고
    • Evidence of reduction in hepatic, cardiac and pituitary iron stores in patients with thalassemia major during long-term therapy with the orally active iron chelating agent
    • N.F. Olivieri N. Beluzzo M. Mucara et al. Evidence of reduction in hepatic, cardiac and pituitary iron stores in patients with thalassemia major during long-term therapy with the orally active iron chelating agent Blood 84 1994 109a
    • (1994) Blood , vol.84
    • Olivieri, N.F.1    Beluzzo, N.2    Mucara, M.3
  • 31
    • 0038472463 scopus 로고    scopus 로고
    • Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan
    • C.T. Peng K.C. Chow J.H. Chen et al. Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan European Journal of Haematology 70 2003 392-397
    • (2003) European Journal of Haematology , vol.70 , pp. 392-397
    • Peng, C.T.1    Chow, K.C.2    Chen, J.H.3
  • 32
    • 0038187626 scopus 로고    scopus 로고
    • Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major
    • A. Piga C. Gaglioti E. Fogliacco F. Tricta Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major Haematologica 70 2003 489-496
    • (2003) Haematologica , vol.70 , pp. 489-496
    • Piga, A.1    Gaglioti, C.2    Fogliacco, E.3    Tricta, F.4
  • 33
    • 0031985039 scopus 로고    scopus 로고
    • Long-term trial of deferiprone in 51 transfusion-dependent iron overloaded patients
    • A.V. Hoffbrand F. Al-Refaie B. Davis et al. Long-term trial of deferiprone in 51 transfusion-dependent iron overloaded patients Blood 91 1998 295-300
    • (1998) Blood , vol.91 , pp. 295-300
    • Hoffbrand, A.V.1    Al-Refaie, F.2    Davis, B.3
  • 34
    • 0036068230 scopus 로고    scopus 로고
    • The safety and effectiveness of deferiprone in a large-scale, 3-year study in Italian patients
    • A. Ceci P. Baiardi M. Felisi et al. The safety and effectiveness of deferiprone in a large-scale, 3-year study in Italian patients British Journal of Haematology 118 2002 330-336
    • (2002) British Journal of Haematology , vol.118 , pp. 330-336
    • Ceci, A.1    Baiardi, P.2    Felisi, M.3
  • 35
    • 0030048681 scopus 로고    scopus 로고
    • Results of long-term iron chelating therapy
    • V. Gabutti A. Piga Results of long-term iron chelating therapy Acta Haematologica 95 1996 26-36
    • (1996) Acta Haematologica , vol.95 , pp. 26-36
    • Gabutti, V.1    Piga, A.2
  • 36
    • 0034631379 scopus 로고    scopus 로고
    • Survival in beta thalassaemia major in the United Kingdom: Data from the U.K. Thalassaemia Register
    • B. Modell M. Khan M. Darlison Survival in beta thalassaemia major in the United Kingdom: Data from the U.K. Thalassaemia Register Lancet 355 2000 2051-2052
    • (2000) Lancet , vol.355 , pp. 2051-2052
    • Modell, B.1    Khan, M.2    Darlison, M.3
  • 37
    • 0037842683 scopus 로고    scopus 로고
    • Reversal of siderotic cardiomyopathy: A prospective study with cardiac magnetic resonance (MR)
    • L. Anderson N. Bunce B. Davis et al. Reversal of siderotic cardiomyopathy: A prospective study with cardiac magnetic resonance (MR) Heart supplement 1 2001 33
    • (2001) Heart , Issue.SUPPL. 1 , pp. 33
    • Anderson, L.1    Bunce, N.2    Davis, B.3
  • 38
    • 0029978555 scopus 로고    scopus 로고
    • Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy
    • J.B. Porter R.D. Abeysinghe L. Marshall et al. Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy Blood 88 1996 705-713
    • (1996) Blood , vol.88 , pp. 705-713
    • Porter, J.B.1    Abeysinghe, R.D.2    Marshall, L.3
  • 39
    • 3042777499 scopus 로고    scopus 로고
    • Combined therapy with deferiprone and desferrioxamine successfully regresses heart failure in patients with β-thalassemia major
    • K.-H. Wu J.S. Chang C.V.H. Tsai C.T. Peng Combined therapy with deferiprone and desferrioxamine successfully regresses heart failure in patients with β-thalassemia major Annals of Hematology 83 2004 471-473
    • (2004) Annals of Hematology , vol.83 , pp. 471-473
    • Wu, K.-H.1    Chang, J.S.2    Tsai, C.V.H.3    Peng, C.T.4
  • 41
    • 0025066690 scopus 로고
    • Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients
    • N.F. Olivieri G. Koren C. Hermann et al. Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients Lancet 336 1990 1275-1279
    • (1990) Lancet , vol.336 , pp. 1275-1279
    • Olivieri, N.F.1    Koren, G.2    Hermann, C.3
  • 42
    • 0026668939 scopus 로고
    • Long-term assessment of efficacy and safety of L1, an oral iron chelator, in transfusion dependent thalassaemia: Indian trial
    • M.B. Agarwal S.S. Gupte C. Viswanathan et al. Long-term assessment of efficacy and safety of L1, an oral iron chelator, in transfusion dependent thalassaemia: Indian trial British Journal of Haematology 82 1992 460-466
    • (1992) British Journal of Haematology , vol.82 , pp. 460-466
    • Agarwal, M.B.1    Gupte, S.S.2    Viswanathan, C.3
  • 45
    • 0035254193 scopus 로고    scopus 로고
    • Deferoxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy
    • W. Breuer M.J.J. Empers P. Pootrakul et al. Deferoxamine-chelatable iron, a component of serum non-transferrin-bound iron, used for assessing chelation therapy Blood 97 2001 792-798
    • (2001) Blood , vol.97 , pp. 792-798
    • Breuer, W.1    Empers, M.J.J.2    Pootrakul, P.3
  • 46
    • 0034928342 scopus 로고    scopus 로고
    • Exploring the 'iron shuttle' hypothesis in chelation therapy: Effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture
    • G. Link A.M. Konijn W. Breuer et al. Exploring the 'iron shuttle' hypothesis in chelation therapy: Effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture Journal of Laboratory and Clinical Medicine 138 2001 130-138
    • (2001) Journal of Laboratory and Clinical Medicine , vol.138 , pp. 130-138
    • Link, G.1    Konijn, A.M.2    Breuer, W.3
  • 47
    • 0141705304 scopus 로고    scopus 로고
    • Labile plasma iron in iron overload: Redox activity and susceptibility to chelation
    • B.P. Esposito W. Breuer P. Sirankapracha et al. Labile plasma iron in iron overload: Redox activity and susceptibility to chelation Blood 102 2003 2670-2677
    • (2003) Blood , vol.102 , pp. 2670-2677
    • Esposito, B.P.1    Breuer, W.2    Sirankapracha, P.3
  • 48
    • 0242584372 scopus 로고    scopus 로고
    • Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients
    • F.H. Mourad A.V. Hoffbrand M. Sheikh-Taha et al. Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients British Journal of Haematology 121 2003 187-189
    • (2003) British Journal of Haematology , vol.121 , pp. 187-189
    • Mourad, F.H.1    Hoffbrand, A.V.2    Sheikh-Taha, M.3
  • 49
    • 0024401997 scopus 로고
    • Agranulocytosis and thrombocytopenia in a patient with Blackfan-Diamond anaemia during oral chelator trial
    • A.V. Hoffbrand A.N. Bartlett P.A. Veys et al. Agranulocytosis and thrombocytopenia in a patient with Blackfan-Diamond anaemia during oral chelator trial Lancet ii 1989 457
    • (1989) Lancet , vol.2 , pp. 457
    • Hoffbrand, A.V.1    Bartlett, A.N.2    Veys, P.A.3
  • 50
    • 0034094839 scopus 로고    scopus 로고
    • Safety profile of the oral iron chelator deferiprone: A multicenter study
    • A.R. Cohen R. Galanello A. Piga et al. Safety profile of the oral iron chelator deferiprone: A multicenter study British Journal of Haematology 108 2000 305-312
    • (2000) British Journal of Haematology , vol.108 , pp. 305-312
    • Cohen, A.R.1    Galanello, R.2    Piga, A.3
  • 51
    • 0042943205 scopus 로고    scopus 로고
    • Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone
    • A. Cohen R. Galanello A. Piga et al. Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone Blood 102 2003 1583-1587
    • (2003) Blood , vol.102 , pp. 1583-1587
    • Cohen, A.1    Galanello, R.2    Piga, A.3
  • 53
    • 0029079707 scopus 로고
    • Results of long-term deferiprone (L1) therapy: A report by the International Study Group on oral iron chelators
    • F.N. Al-Refaie C. Hershko A.V. Hoffbrand et al. Results of long-term deferiprone (L1) therapy: A report by the International Study Group on oral iron chelators British Journal of Haematology 91 1995 224-229
    • (1995) British Journal of Haematology , vol.91 , pp. 224-229
    • Al-Refaie, F.N.1    Hershko, C.2    Hoffbrand, A.V.3
  • 54
    • 0028180337 scopus 로고
    • Differential toxicity of alpha-keto hydroxypyridine iron chelators and desferrioxamine to human haemopoietic precursors in vitro
    • J.M. Cunningham F.N. Al-Refaie A.E. Hunter et al. Differential toxicity of alpha-keto hydroxypyridine iron chelators and desferrioxamine to human haemopoietic precursors in vitro European Journal of Haematology 52 1994 176-179
    • (1994) European Journal of Haematology , vol.52 , pp. 176-179
    • Cunningham, J.M.1    Al-Refaie, F.N.2    Hunter, A.E.3
  • 55
    • 0025130087 scopus 로고
    • Long term trial with the oral iron chelator 1-2-dimethyl-3-hydroxypyrid-4-one (L1).II. Clinical observations
    • A.N. Bartlett A.V. Hoffbrand G.J. Kontoghiorghes Long term trial with the oral iron chelator 1-2-dimethyl-3-hydroxypyrid-4-one (L1).II. Clinical observations British Journal of Haematology 76 1990 301-304
    • (1990) British Journal of Haematology , vol.76 , pp. 301-304
    • Bartlett, A.N.1    Hoffbrand, A.V.2    Kontoghiorghes, G.J.3
  • 56
    • 0031046747 scopus 로고    scopus 로고
    • Agranulocytosis, arthritis and systemic vasculitis in a patient receiving the oral iron chelator L1 (deferiprone)
    • A. Castriota-Scanderbeg M. Sacco Agranulocytosis, arthritis and systemic vasculitis in a patient receiving the oral iron chelator L1 (deferiprone) British Journal of Haematology 96 1997 254-255
    • (1997) British Journal of Haematology , vol.96 , pp. 254-255
    • Castriota-Scanderbeg, A.1    Sacco, M.2
  • 57
    • 0028630549 scopus 로고
    • Zinc concentration in patients with iron overload receiving iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one or deferoxamine
    • F.N. Al-Refaie B. Wonke D.G. Wickens et al. Zinc concentration in patients with iron overload receiving iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one or deferoxamine Journal of Clinical Pathology 47 1994 657-660
    • (1994) Journal of Clinical Pathology , vol.47 , pp. 657-660
    • Al-Refaie, F.N.1    Wonke, B.2    Wickens, D.G.3
  • 58
    • 0026643003 scopus 로고
    • Efficacy and possible adverse effects of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in thalassemia major
    • F.N. Al-Refaie B. Wonke A.V. Hoffbrand et al. Efficacy and possible adverse effects of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in thalassemia major Blood 80 1992 593-599
    • (1992) Blood , vol.80 , pp. 593-599
    • Al-Refaie, F.N.1    Wonke, B.2    Hoffbrand, A.V.3
  • 59
    • 0032481094 scopus 로고    scopus 로고
    • Iron chelation with oral deferiprone in patients with thalassemia
    • (letter)
    • F. Callea Iron chelation with oral deferiprone in patients with thalassemia (letter) New England Journal of Medicine 339 1998 1711-1719
    • (1998) New England Journal of Medicine , vol.339 , pp. 1711-1719
    • Callea, F.1
  • 60
    • 0032481133 scopus 로고    scopus 로고
    • Iron chelatiion with oral deferiprone in patients with thalassemia
    • (letter)
    • M. Stella G. Pinzello A. Maggio Iron chelatiion with oral deferiprone in patients with thalassemia (letter) New England Journal of Medicine 339 1998 1712
    • (1998) New England Journal of Medicine , vol.339 , pp. 1712
    • Stella, M.1    Pinzello, G.2    Maggio, A.3
  • 61
    • 0031859182 scopus 로고    scopus 로고
    • Liver iron and fibrosis during long-term treatment with deferiprone in Swiss thalassaemic patients
    • P. Tondury A. Zimmermann P. Nielsen et al. Liver iron and fibrosis during long-term treatment with deferiprone in Swiss thalassaemic patients British Journal of Haematology 101 1998 413-415
    • (1998) British Journal of Haematology , vol.101 , pp. 413-415
    • Tondury, P.1    Zimmermann, A.2    Nielsen, P.3
  • 62
    • 0003292420 scopus 로고    scopus 로고
    • No progression of liver fibrosis in thalassemia major during deferiprone or desferrioxamine iron chelation
    • A.P. Piga S. Facello C. Gaglioti et al. No progression of liver fibrosis in thalassemia major during deferiprone or desferrioxamine iron chelation Blood 92 1998 216
    • (1998) Blood , vol.92 , pp. 216
    • Piga, A.P.1    Facello, S.2    Gaglioti, C.3
  • 64
    • 0033693910 scopus 로고    scopus 로고
    • The Sydney Children's Hospital experience with the oral iron chelator deferiprone (L1)
    • V. Berdoukas T. Bohane C. Eagle et al. The Sydney Children's Hospital experience with the oral iron chelator deferiprone (L1) Transfusional Science 23 2000 239-240
    • (2000) Transfusional Science , vol.23 , pp. 239-240
    • Berdoukas, V.1    Bohane, T.2    Eagle, C.3
  • 65
    • 0036721452 scopus 로고    scopus 로고
    • Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia
    • A. Wanless G. Sweeney A.P. Dhillon et al. Lack of progressive hepatic fibrosis during long-term therapy with deferiprone in subjects with transfusion-dependent beta-thalassemia Blood 100 2002 1566-1569
    • (2002) Blood , vol.100 , pp. 1566-1569
    • Wanless, A.1    Sweeney, G.2    Dhillon, A.P.3
  • 66
    • 9144230310 scopus 로고    scopus 로고
    • Five year trial of deferiprone chelation therapy in thalassemia major patients
    • in press
    • A. Taher E. Aoun A.I. Sharra et al. Five year trial of deferiprone chelation therapy in thalassemia major patients Acta Haematologica 2004 in press
    • (2004) Acta Haematologica
    • Taher, A.1    Aoun, E.2    Sharra, A.I.3
  • 67
    • 0033947261 scopus 로고    scopus 로고
    • Treatment with deferiprone (L1) in a thalassemic patient with bone lesions due to desferrioxamine
    • A. Mangiagli V. De Sanctis S. Campisi et al. Treatment with deferiprone (L1) in a thalassemic patient with bone lesions due to desferrioxamine Journal of Pediatric Endocrinology & Metabolism 13 2000 677-680
    • (2000) Journal of Pediatric Endocrinology & Metabolism , vol.13 , pp. 677-680
    • Mangiagli, A.1    De Sanctis, V.2    Campisi, S.3
  • 68
    • 0036090462 scopus 로고    scopus 로고
    • Comparisons of the effects of deferiprone versus deferoxamine on growth and virulence of Yersinia enterocolitica
    • B. Lesic J. Foulton E. Carniel Comparisons of the effects of deferiprone versus deferoxamine on growth and virulence of Yersinia enterocolitica Antimicrobial Agents and Chemotherapy 46 2002 1741-1745
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , pp. 1741-1745
    • Lesic, B.1    Foulton, J.2    Carniel, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.