Agranulocytosis, arthritis and systemic vasculitis in a patient receiving the oral iron chelator L1 (deferiprone)

British Journal of Haematology

Volumn 96, Issue 2, 1997, Pages 254-255

  Castriota Scanderbeg, Alessandro ^a   Sacco, Michele ^b  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

Author keywords

immune function; L1 (deferiprone); thalassaemia major; vasculitis

Indexed keywords

CHELATING AGENT; DEFERIPRONE;

ADULT; AGRANULOCYTOSIS; ARTHRITIS; ARTICLE; CASE REPORT; FEMALE; HUMAN; PRIORITY JOURNAL; THALASSEMIA; VASCULITIS;

EID: 0031046747     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.d01-2014.x     Document Type: Article

References (7)

1. Al-Refaie, F.N., Hershko, C., Hoflbrand, A.V., Kosaryan, M., Olivieri, N.F., Tondury, P. & Wonke, B. (1995) Results of long-term deferiprone (L1) therapy: a report by the International Study Group on oral iron chelators. British Journal of Haematology, 91, 224-229.
2. Al-Refaie, F.N., Veys, P.A., Wilkes, S., Wonke, B. & Hoffbraud, A.V. (1993) Agranulocytosis in a patient with thalassemia major during treatment with the oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one. Acta Haematologica, 89, 86-90
3. Berkovitch, M., Laxer, M.L., Inman, R., Koren, G., Pritzker, K.P.H., Fritzler, M.J. & Olivieri, N.F. (1994) Arthropathy in thalassaemia patients receiving deferiprone. Lancet, 345, 1471-1472.
4. Hoffbrand, A.V., Bartlett, A.N., Veys, P.A., O'Connor, N.T.J. & Kontoghiorghes. G.J. (1989) Agranulocytosis and thrombo-cytopenia in patient with Blackfan-Diamond anaemia during oral chelator trial. Lancet, ii, 467.
5. Hoffbrand, A.V. (1996) Oral iron chelation. Seminars in Hematology, 33, 1-8.
6. Kontoghiorghes, G.J., Aldouri, M.A., Sheppard, L. & Hoffbrand, A.V. (1987) 1,2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for treatment of iron overload. Lancet, i, 1294-1295.
7. Mehta, J., Singhal, S., Revankar, R., Walvalkar, A., Chablani, A. & Mehta, B.C. (1991) Fatal systemic lupus erythematosus in patient taking oral iron chelator L1, Lancet, 337, 298.