1,2,5-thiadiazole analogues of aceclidine as potent m1 muscarinic agonists

Journal of Medicinal Chemistry

Volumn 41, Issue 3, 1998, Pages 379-392

  Ward, John S ^a   Merritt, Leander ^a   Calligaro, David O ^a   Bymaster, Franklin P ^a   Shannon, Harlan E ^a   Mitch, Charles H ^a   Whitesitt, Celia ^a   Brunsting, David ^a   Sheardown, Malcolm J ^b   Olesen, Preben H ^b   Swedberg, Michael D B ^b   Jeppesen, Lone ^b   Sauerberg, Per ^b  

^a ELI LILLY AND COMPANY   (United States)

^b NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3 (BUTYLOXY) 4 (1 AZABICYCLO[2.2.2]OCT 3 YLOXY) 1,2,5 THIADIAZOLE; 3 (BUTYLTHIO) 4 (1 AZABICYCLO[2.2.2]OCT 3 YLOXY) 1,2,5 THIADIAZOLE; ACECLIDINE; ACETYLCHOLINE; ARECOLINE; MUSCARINIC M1 RECEPTOR AGONIST; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; XANOMELINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; SALIVATION; STRUCTURE ACTIVITY RELATION; TREMOR;

ANIMALS; BRAIN; CELL LINE; ELECTROSTATICS; HYDROLYSIS; MALE; MICE; MODELS, MOLECULAR; MUSCARINIC AGONISTS; PHOSPHATIDYLINOSITOLS; QUINUCLIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; THIADIAZOLES;

EID: 14444284097     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970125n     Document Type: Article

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