Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: Potential application for the treatment of irritable bowel syndrome

Journal of Medicinal Chemistry

Volumn 40, Issue 4, 1997, Pages 538-546

  Mitch, Charles H ^a   Brown, Thomas J ^a   Bymaster, Frank P ^a   Calligaro, David O ^a   Dieckman, Donna ^a   Merrit, Leander ^a   Peters, Steven C ^a   Quimby, Steven J ^a   Shannon, Harlan E ^a   Shipley, Lisa A ^a   Ward, John S ^a   Hansen, Kristian ^b   Olesen, Preben H ^b   Sauerberg, Per ^b   Sheardown, Malcolm J ^b   Swedberg, Michael D B ^b   Suzdak, Peter ^b   Greenwood, Beverley ^a,c  

^a ELI LILLY AND COMPANY   (United States)

^b NOVO NORDISK A S   (Denmark)

^c PRESBYTERIAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 [4 [(4,4,4 TRIFLUOROBUTYL)THIO] 1,2,5 THIADIAZOL 3 YL] 1 AZABICYCLO[3.2.1]OCTANE; ANALGESIC AGENT; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; FERRET; INTESTINE CONTRACTION; IRRITABLE COLON; JEJUNUM; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANALGESICS, NON-NARCOTIC; ANIMALS; COLONIC DISEASES, FUNCTIONAL; DRUG DESIGN; FERRETS; GASTROINTESTINAL MOTILITY; MALE; MICE; MUSCARINIC AGONISTS; NOCICEPTORS; OXOTREMORINE;

EID: 15144351726     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9602470     Document Type: Article

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