Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists

Journal of Medicinal Chemistry

Volumn 41, Issue 1, 1998, Pages 74-95

  Curtin, Michael L ^a   Davidsen, Steven K ^a   Heyman, H Robin ^a   Garland, Robert B ^a   Sheppard, George S ^a   Florjancic, Alan S ^a   Xu, Lianhong ^a   Carrera Jr , George M ^a   Steinman, Douglas H ^a   Trautmann, Jeff A ^a   Albert, Daniel H ^a   Magoc, Terrance J ^a   Tapang, Paul ^a   Rhein, David A ^a   Conway, Richard G ^a   Luo, Gongjin ^a   Denissen, Jon F ^a   Marsh, Kennan C ^a   Morgan, Douglas W ^a   Summers, James B ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (N,N DIMETHYLCARBAMOYL) 4 ETHYNYL 3 (3 FLUORO 4 [(1H 2 METHYLIMIDAZO[4,5 C] PYRID 1 YL)METHYL]BENZOYL]INDOLE HYDROCHLORIDE; 1 ACETOXYMETHYL 3 [7 [1 (N,N DIMETHYLCARBAMOYL) 6 (4 FLUOROPHENYL) 3 INDOLYL] 1H,3H PYRROLO[1,2 C]THIAZOL 3 YL]PYRIDINIUM CHLORIDE; LEXIPAFANT; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; DOG; DRUG POTENCY; DRUG SOLUBILITY; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE ACTIVATION;

ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD PLATELETS; CAPILLARY PERMEABILITY; DOGS; FEMALE; GUINEA PIGS; HUMANS; IMIDAZOLES; MACACA FASCICULARIS; MALE; MOLECULAR STRUCTURE; PLATELET ACTIVATING FACTOR; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 14444283889     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970389+     Document Type: Article

References (48)

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