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Volumn 325, Issue 1, 1997, Pages 69-80

Pharmacology of ABT-491, a highly potent platelet-activating factor receptor antagonist

Author keywords

ABT 491; Ca2+ flux; Degranulation; Endotoxemia; PAF (platelet activating factor); PAF receptor antagonist; Superoxide anion; Vascular permeability

Indexed keywords

4 ETHYNYL 3 [3 FLUORO 4 [(2 METHYL 1H IMIDAZO[4,5 C]PYRIDIN 1 YL)METHYL]BENZOYL] N,N DIMETHYL 1H INDOLE 1 CARBOXAMIDE; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 0030963469     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00109-X     Document Type: Article
Times cited : (24)

References (50)
  • 3
    • 0023034188 scopus 로고
    • Phagocytic leukocyte oxygenation activities and chemiluminescence: A kinetic approach to analysis
    • Allen, R.C., 1986. Phagocytic leukocyte oxygenation activities and chemiluminescence: a kinetic approach to analysis. Methods Enzymol. 133, 449-493.
    • (1986) Methods Enzymol. , vol.133 , pp. 449-493
    • Allen, R.C.1
  • 5
    • 0011388931 scopus 로고
    • The effect of a specific oral PAF-antagonist, MK-287, on antigen-induced early and late asthmatic reactions in man
    • Bel, E.H., De Smet, M., Rossing, T.H., Timmers, M.C., Dijkman, J.H., Sterk, P.J., 1991. The effect of a specific oral PAF-antagonist, MK-287, on antigen-induced early and late asthmatic reactions in man. Am. Rev. Respir. Dis. 143, A811.
    • (1991) Am. Rev. Respir. Dis. , vol.143
    • Bel, E.H.1    De Smet, M.2    Rossing, T.H.3    Timmers, M.C.4    Dijkman, J.H.5    Sterk, P.J.6
  • 6
    • 0026693018 scopus 로고
    • Protective effect of SR 27417, a novel PAF antagonist, on PAF- Or endotoxin-induced hypotension in the rat and the guinea-pig
    • Bernat, A., Herbert, J.M., Salel, V., Lespy, L., Maffrand, J.P., 1992. Protective effect of SR 27417, a novel PAF antagonist, on PAF- or endotoxin-induced hypotension in the rat and the guinea-pig. J. Lipid Mediat. 51, 41-48.
    • (1992) J. Lipid Mediat. , vol.51 , pp. 41-48
    • Bernat, A.1    Herbert, J.M.2    Salel, V.3    Lespy, L.4    Maffrand, J.P.5
  • 8
    • 0019789918 scopus 로고
    • A specific hydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine hypotensive platelet activating lipid
    • Blank, M.L., Lee, T.C., Fitzgerald, V., Snyder, F., 1981. A specific hydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine hypotensive platelet activating lipid. J. Biol. Chem. 256, 175-178.
    • (1981) J. Biol. Chem. , vol.256 , pp. 175-178
    • Blank, M.L.1    Lee, T.C.2    Fitzgerald, V.3    Snyder, F.4
  • 12
    • 0023577811 scopus 로고
    • Pharmacologic modulation of PAF-induced mortality in mice
    • Carlson, R.P., O'Neill-Davis, L., Chang, J., 1987. Pharmacologic modulation of PAF-induced mortality in mice. Agents Actions 21, 379-381.
    • (1987) Agents Actions , vol.21 , pp. 379-381
    • Carlson, R.P.1    O'Neill-Davis, L.2    Chang, J.3
  • 13
    • 0023213312 scopus 로고
    • Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats
    • Chang, S.W., Feddersen, C.O., Henson, P.M., Voelkel, N.F., 1987. Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats. J. Clin. Invest. 79, 1498-1509.
    • (1987) J. Clin. Invest. , vol.79 , pp. 1498-1509
    • Chang, S.W.1    Feddersen, C.O.2    Henson, P.M.3    Voelkel, N.F.4
  • 15
    • 0011435750 scopus 로고
    • The effect of Sch-37370, a dual PAF and histamine antagonist, on the bronchoconstriction induced in asthmatics by cold, dry air isocapnic hyperventilation
    • Dermarkarian, R.M., Israel, E., Rosenberg, M.A., Jansen, A., Danzig, M.R., Fourre, J., Drazen, J.M., 1991. The effect of Sch-37370, a dual PAF and histamine antagonist, on the bronchoconstriction induced in asthmatics by cold, dry air isocapnic hyperventilation. Am. Rev. Respir. Dis. 143, A812.
    • (1991) Am. Rev. Respir. Dis. , vol.143
    • Dermarkarian, R.M.1    Israel, E.2    Rosenberg, M.A.3    Jansen, A.4    Danzig, M.R.5    Fourre, J.6    Drazen, J.M.7
  • 16
    • 0023220532 scopus 로고
    • Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay
    • Dewald, B., Baggiolini, M., 1987. Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay. Biochem. Pharmacol. 36, 2505-2510.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 2505-2510
    • Dewald, B.1    Baggiolini, M.2
  • 17
    • 0021797838 scopus 로고
    • Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone
    • Doebber, T.W., Wu, M.S., Robbins, J.C., Choy, B.M., Chang, M.N., Shen, T.Y., 1985. Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. Biochem. Biophys. Res. Commun. 127, 799-808.
    • (1985) Biochem. Biophys. Res. Commun. , vol.127 , pp. 799-808
    • Doebber, T.W.1    Wu, M.S.2    Robbins, J.C.3    Choy, B.M.4    Chang, M.N.5    Shen, T.Y.6
  • 18
    • 0027276186 scopus 로고
    • Effect of a PAF antagonist WEB-2086, on allergen induced asthmatic response
    • Freitag, A., Watson, R.M., Matsos, G., Eastwood, C., O'Byrne, P.M., 1993. Effect of a PAF antagonist WEB-2086, on allergen induced asthmatic response. Thorax 48, 594-598.
    • (1993) Thorax , vol.48 , pp. 594-598
    • Freitag, A.1    Watson, R.M.2    Matsos, G.3    Eastwood, C.4    O'Byrne, P.M.5
  • 19
    • 0027228351 scopus 로고
    • Mechanism and regulation of neutrophil priming by platelet-activating factor
    • Gay, J.C., 1993. Mechanism and regulation of neutrophil priming by platelet-activating factor. J. Cell Physiol. 156, 189-197.
    • (1993) J. Cell Physiol. , vol.156 , pp. 189-197
    • Gay, J.C.1
  • 20
    • 0021895138 scopus 로고
    • 2+ indicators with greatly improved fluorescence properties
    • 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3445.
    • (1985) J. Biol. Chem. , vol.260 , pp. 3440-3445
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.3
  • 22
    • 0027339777 scopus 로고
    • 3H]SR 27417, a novel platelet-activating factor (PAF) receptor antagonist, to rabbit and human platelets and polymorphonuclear leukocytes
    • 3H]SR 27417, a novel platelet-activating factor (PAF) receptor antagonist, to rabbit and human platelets and polymorphonuclear leukocytes. Biochem. Pharmacol. 45, 51-58.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 51-58
    • Herbert, J.M.1    Laplace, M.C.2    Maffrand, J.P.3
  • 24
    • 0022860714 scopus 로고
    • Species difference in the specific receptors of platelet activating factor
    • Hwang, S.-B., Lam, M.-H., 1986. Species difference in the specific receptors of platelet activating factor. Biochem. Pharmacol. 35, 4511-4518.
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 4511-4518
    • Hwang, S.-B.1    Lam, M.-H.2
  • 25
    • 0020504723 scopus 로고
    • Specific receptor sites for 1-O-alkyl-2-O-sn-glycero-3-phosphocholine (platelet activating factor) on rabbit platelet and guinea pig smooth muscle membranes
    • Hwang, S.B., Lee, C.S., Cheah, M.J., Shen, T.Y., 1983. Specific receptor sites for 1-O-alkyl-2-O-sn-glycero-3-phosphocholine (platelet activating factor) on rabbit platelet and guinea pig smooth muscle membranes. Biochemistry 22, 4756-4763.
    • (1983) Biochemistry , vol.22 , pp. 4756-4763
    • Hwang, S.B.1    Lee, C.S.2    Cheah, M.J.3    Shen, T.Y.4
  • 26
    • 0021805569 scopus 로고
    • Specific binding sites for platelet-activating factor in human lung tissues
    • Hwang, S.B., Lam, M.H., Shen, T.Y., 1985a. Specific binding sites for platelet-activating factor in human lung tissues. Biochem. Biophys. Res. Commun. 128, 972-979.
    • (1985) Biochem. Biophys. Res. Commun. , vol.128 , pp. 972-979
    • Hwang, S.B.1    Lam, M.H.2    Shen, T.Y.3
  • 27
    • 0021846565 scopus 로고
    • Characterization of cutaneous vascular permeability induced by PAF in guinea pigs and rats and its inhibition by PAF receptor antagonists
    • Hwang, S.B., Li, C.L., Lam, M.H., Shen, T.Y., 1985b. Characterization of cutaneous vascular permeability induced by PAF in guinea pigs and rats and its inhibition by PAF receptor antagonists. Lab. Invest. 52, 617-630.
    • (1985) Lab. Invest. , vol.52 , pp. 617-630
    • Hwang, S.B.1    Li, C.L.2    Lam, M.H.3    Shen, T.Y.4
  • 28
    • 0025823829 scopus 로고
    • Platelet activating factor. A review of its effects, antagonists and possible future clinical implications
    • 174-204.
    • Koltai, M., Hosford, D., Guinot, P., Esanu, A., Braquet, P., 1991. Platelet activating factor. A review of its effects, antagonists and possible future clinical implications. Drugs 42, 9-29, 174-204.
    • (1991) Drugs , vol.42 , pp. 9-29
    • Koltai, M.1    Hosford, D.2    Guinot, P.3    Esanu, A.4    Braquet, P.5
  • 29
    • 0023747170 scopus 로고
    • Activation of the human neutrophil by calcium-mobilizing ligands. II. Correlation of calcium, diacyl glycerol and phosphatidic acid generation with superoxide anion generation
    • Korchak, H.M., Vosshall, L.B., Haines, K.A., Wilkenfeld, C., Lundquist, K.F., Weissmann, G., 1988. Activation of the human neutrophil by calcium-mobilizing ligands. II. Correlation of calcium, diacyl glycerol and phosphatidic acid generation with superoxide anion generation. J. Biol. Chem. 263, 11098-11105.
    • (1988) J. Biol. Chem. , vol.263 , pp. 11098-11105
    • Korchak, H.M.1    Vosshall, L.B.2    Haines, K.A.3    Wilkenfeld, C.4    Lundquist, K.F.5    Weissmann, G.6
  • 31
    • 0019450873 scopus 로고
    • Human platelet stimulation by acetyl glyceryl ether phosphorylcholine
    • McManus, L.M., Hanahan, D.J., Pinckard, R.N., 1981. Human platelet stimulation by acetyl glyceryl ether phosphorylcholine. J. Clin. Invest. 67, 903-906.
    • (1981) J. Clin. Invest. , vol.67 , pp. 903-906
    • McManus, L.M.1    Hanahan, D.J.2    Pinckard, R.N.3
  • 34
    • 0020504914 scopus 로고
    • Studies on the stimulation of human blood platelets by semi-synthetic platelet-activating factor
    • Ostermann, G., Till, U., Thielmann, K., 1983. Studies on the stimulation of human blood platelets by semi-synthetic platelet-activating factor. Thromb. Res. 30, 127-136.
    • (1983) Thromb. Res. , vol.30 , pp. 127-136
    • Ostermann, G.1    Till, U.2    Thielmann, K.3
  • 36
    • 0025153389 scopus 로고
    • Contribution of platelet activating factor to hemodynamic and sympathetic responses to bacterial endotoxin in conscious rats
    • Qi, M., Jones, S.B., 1990. Contribution of platelet activating factor to hemodynamic and sympathetic responses to bacterial endotoxin in conscious rats. Circ. Shock 32, 153-163.
    • (1990) Circ. Shock , vol.32 , pp. 153-163
    • Qi, M.1    Jones, S.B.2
  • 37
    • 0025319045 scopus 로고
    • Assessment of vascular permeability increase in the mouse by dye leakage during paw edema
    • Qu, X.F., Hayashi, M., Yamaki, K., Oh-Ishi, S.O., 1990. Assessment of vascular permeability increase in the mouse by dye leakage during paw edema. Jpn. J. Pharmacol. 52, 500-503.
    • (1990) Jpn. J. Pharmacol. , vol.52 , pp. 500-503
    • Qu, X.F.1    Hayashi, M.2    Yamaki, K.3    Oh-Ishi, S.O.4
  • 38
    • 0027285682 scopus 로고
    • Mechanisms and management of septic shock
    • Rackow, E.C., Astiz, M.E., 1993. Mechanisms and management of septic shock. Crit. Care Clin. 9, 219-237.
    • (1993) Crit. Care Clin. , vol.9 , pp. 219-237
    • Rackow, E.C.1    Astiz, M.E.2
  • 39
    • 0025898983 scopus 로고
    • Pharmacological modulation of PAF: A therapeutic approach to endotoxin shock
    • Sanchez Crespo, M., Fernandez-Gallardo, S., 1991. Pharmacological modulation of PAF: a therapeutic approach to endotoxin shock. J. Lipid Mediat. 4, 127-144.
    • (1991) J. Lipid Mediat. , vol.4 , pp. 127-144
    • Sanchez Crespo, M.1    Fernandez-Gallardo, S.2
  • 40
    • 84982328496 scopus 로고
    • pA, a new scale for the measurement of drug antagonism
    • Schild, H.O., 1947. pA, a new scale for the measurement of drug antagonism. Br. J. Pharmacol. 2, 189-195.
    • (1947) Br. J. Pharmacol. , vol.2 , pp. 189-195
    • Schild, H.O.1
  • 43
    • 0029193760 scopus 로고
    • Platelet activating factor antagonists
    • Summers, J.B., Albert, D.H., 1995. Platelet activating factor antagonists. Adv. Pharmacol. 32, 67-168.
    • (1995) Adv. Pharmacol. , vol.32 , pp. 67-168
    • Summers, J.B.1    Albert, D.H.2
  • 44
    • 0025900073 scopus 로고
    • Platelet-activating factor produces shock, in vivo complement activation, and tissue injury in mice
    • Sun, X.M., Hsueh, W., 1991. Platelet-activating factor produces shock, in vivo complement activation, and tissue injury in mice. J. Immunol. 147, 509-514.
    • (1991) J. Immunol. , vol.147 , pp. 509-514
    • Sun, X.M.1    Hsueh, W.2
  • 45
    • 0342526883 scopus 로고
    • Effectiveness of a potent platelet activating factor antagonist, WEB-2086, on asthma: A multicenter, double-blind, placebo-controlled study
    • Tamura, G., Takishima, T., Mue, S., Makino, S., Itoh, K., Miyamoto, T., Shida, T., Nakajima, S., 1994. Effectiveness of a potent platelet activating factor antagonist, WEB-2086, on asthma: a multicenter, double-blind, placebo-controlled study. Eur. Respir. J. 7 (Suppl. 18), 752.
    • (1994) Eur. Respir. J. , vol.7 , Issue.SUPPL. 18 , pp. 752
    • Tamura, G.1    Takishima, T.2    Mue, S.3    Makino, S.4    Itoh, K.5    Miyamoto, T.6    Shida, T.7    Nakajima, S.8
  • 46
    • 0021969397 scopus 로고
    • Is platelet activating factor (PAF) a mediator of endotoxin shock?
    • Terashita, Z., Imura, Y., Nishikawa, K., Sumida, S., 1985. Is platelet activating factor (PAF) a mediator of endotoxin shock? Eur. J. Pharmacol. 109, 257-261.
    • (1985) Eur. J. Pharmacol. , vol.109 , pp. 257-261
    • Terashita, Z.1    Imura, Y.2    Nishikawa, K.3    Sumida, S.4
  • 47
    • 0026777298 scopus 로고
    • Pharmacological profile of TCV-309 - A potent PAF antagonist
    • Terashita, Z., Takatani, M., Nishikawa, K., 1992. Pharmacological profile of TCV-309 - a potent PAF antagonist. J. Lipid Mediat. 5, 183-185.
    • (1992) J. Lipid Mediat. , vol.5 , pp. 183-185
    • Terashita, Z.1    Takatani, M.2    Nishikawa, K.3
  • 49
    • 0023203547 scopus 로고
    • Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists
    • Wallace, J.L., Steel, G., Whittle, B.J., Lagente, V., Vargaftig, B., 1987. Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists. Gastroenterology 93, 765-773.
    • (1987) Gastroenterology , vol.93 , pp. 765-773
    • Wallace, J.L.1    Steel, G.2    Whittle, B.J.3    Lagente, V.4    Vargaftig, B.5
  • 50
    • 0025271408 scopus 로고
    • Effects of a PAF antagonist (BN-52063) on bronchoconstriction and platelet activation during exercise induced asthma
    • Wilkens, J.H., Wilkens, H., Uffmann, J., Bovers, J., Fabel, H., Frolich, J.C., 1990. Effects of a PAF antagonist (BN-52063) on bronchoconstriction and platelet activation during exercise induced asthma. Br. J. Clin. Pharmacol. 29, 85-91.
    • (1990) Br. J. Clin. Pharmacol. , vol.29 , pp. 85-91
    • Wilkens, J.H.1    Wilkens, H.2    Uffmann, J.3    Bovers, J.4    Fabel, H.5    Frolich, J.C.6


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