Spontaneous hypoglycaemia after pancreas transplantation in type 1 diabetes mellitus

Diabetic Medicine

Volumn 15, Issue 12, 1998, Pages 991-996

  Battezzati, A ^a,d   Bonfatti, D ^a   Benedini, S ^a   Calori, G ^a   Caldara, R ^a   Mazzaferro, V ^b   Elli, A ^c   Secchi, A ^a   Di Carlo, V ^a   Pozza, G ^a   Luzi, L ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Blood glucose; Hypoglycaemia; Insulin; Pancreas transplantation; Type 1 diabetes mellitus

Indexed keywords

ADULT; ARTICLE; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; GRAFT REJECTION; HUMAN; HYPOGLYCEMIA; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PANCREAS TRANSPLANTATION; POSTOPERATIVE COMPLICATION; TREATMENT OUTCOME;

ADULT; BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; FEMALE; HUMANS; HYPOGLYCEMIA; INSULIN; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; MALE; PANCREAS TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; TIME FACTORS;

EID: 14444272509     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9136(1998120)15:12<991::AID-DIA717>3.0.CO;2-Q     Document Type: Article

References (44)

1. Luzi L, Secchi A, Facchini F, Battezzati A, Staudacher C, Spotti D, et al. Reduction of insulin resistance by combined kidney-pancreas transplantation in Type 1 (insulin-dependent) diabetic patients. Diabetologia 1990; 33: 549-556.
2. Luzi L, Battezzati A, Perseghin G, Bianchi E, Terruzzi I, Spotti D, et al. Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients. J Clin Invest 1994; 93: 1948-1958.
3. Luzi L, Groop LC, Perseghin G, Taskinen M-R, Hilden H, Bianchi E, et al. Effect of pancreas transplantation on free fatty acid metabolism in uremic IDDM patients. Diabetes 1996; 45: 354-360.
4. Bohman SO, Tyden G, Wilczek H, Lundgren G, Jaremko G, Gunnarsson R, et al. Prevention of kidney graft diabetic nephropathy by pancreas transplantation in man. Diabetes 1985; 34: 306-308.
5. Bilous RW, Mauer SM, Sutherland DE, Najarian JS, Goetz FC, Steffes MW. The effects of pancreas transplantation on the glomerular structure of renal allografts in patients with insulin-dependent diabetes. N Engl J Med 1989; 321: 80-85.
6. Navarro X, Kennedy WR, Loewenson RB, Sutherland DE. Influence of pancreas transplantation on cardiorespiratory reflexes, nerve conduction, and mortality in diabetes mellitus. Diabetes 1990; 39: 802-806.
7. Kennedy WR, Navarro X, Goetz FC, Sutherland DE, Najarian JS. Effects of pancreatic transplantation on diabetic neuropathy. N Engl J Med 1 990; 322: 1031-1037.
8. Solders G, Wilczek H, Gunnarsson R, Tyden G, Persson A, Groth CG. Effects of combined pancreatic and renal transplantation on diabetic neuropathy: a two-year follow-up study. Lancet 1987; 2: 1232-1235.
9. Muller-Felber W, Landgraf R, Scheuer R, Wagner S, Reimers CD, Nusser J, et al. Diabetic neuropathy 3 years after successful pancreas and kidney transplantation. Diabetes 1993; 42: 1482-1486.
10. Ramsay RC, Goetz FC, Sutherland DE, Mauer SM, Robison LL, Cantrill HL, et al. Progression of diabetic retinopathy after pancreas transplantation for insulin-dependent diabetes mellitus. N Engl J Med 1988; 318: 208-214.
11. Scheider A, Meyer-Schwickerath E, Nusser J, Land W, Landgraf R. Diabetic retinopathy and pancreas transplantation: a 3-year follow-up. Diabetologia 1991; 34: (suppl 1): S95-S99.
12. Bandello F, Vigano C, Secchi A, Martinenghi S, Caldara R, Di Carlo V, et al. Effect of pancreas transplantation on diabetic retinopathy: a 20-case report. Diabetologia 1991; 34 (suppl 1): S92-S94.
13. Cryer PE. Hypoglycemia begets hypoglycemia in IDDM. Diabetes 1993; 42: 1691-1693.
14. Bolinder J, Wahrenberg H, Persson A, Linde B, Tyden G, Groth CG, Ostman J. Effect of pancreas transplantation on glucose counterregulation in insulin-dependent diabetic patients prone to severe hypoglycaemia. J Intern Med 1991; 230: 527-533.
15. Bolinder J, Wahrenberg H, Linde B, Tyden G, Groth CG, Ostman J. Improved glucose counterregulation after pancreas transplantation in diabetic patients with unawareness of hypoglycemia. Transplant Proc 1991; 23: 1667-1669.
16. Diem P, Redmon JB, Abid M, Moran A, Sutherland DE, Halter JB, Robertson RP. Glucagon, catecholamine and pancreatic polypeptide secretion in type I diabetic recipients of pancreas allografts. J Clin Invest 1990; 86: 2008-2013.
17. Kendall DM, Rooney DP, Smets YF, Salazar Bolding L, Robertson RP. Pancreas transplantation restores epinephrine response and symptom recognition during hypoglycemia in patients with long-standing type I diabetes and autonomic neuropathy. Diabetes 1997; 46: 249-257.
18. Barrou Z, Seaquist ER, Robertson RP. Pancreas transplantation in diabetic humans normalizes hepatic glucose production during hypoglycemia. Diabetes 1994; 43: 661-666.
19. Battezzati A, Luzi L, Perseghin G, Bianchi E, Spotti D, Secchi A, et al. Persistence of counter-regulatory abnormalities in insulin-dependent diabetes mellitus after pancreas transplantation. Eur J Clin Invest 1994; 24: 751-758.
20. Zehrer CL, Gross CR. Prevalence of 'low blood glucose' symptoms and quality of life in pancreas transplant recipients. Clin Transplantation 1993; 7: 312-319.
21. Cottrell DA, Henry ML, O'Dorisio TM, Tesi RJ, Ferguson RM, Osei K. Hypoglycemia after successful pancreas transplantation in type I diabetic patients. Diabetes Care 1991; 14: 1111-1113.
22. Larsen JL, Stratta RJ, Miller SA, Taylor RJ. Hypoglycemic symptoms following pancreas transplantation. Clin Transplantation 1993; 7: 520-524.
23. Larsen JL, Forsman JA, Miller SA, Taylor RJ, Stratta RJ. Symptoms of hypoglycemia are experienced by majority of combined pancreas-kidney transplant recipients but documented hypoglycemia was infrequent. Transplant Proc 1994; 26: 476-477.
24. Sollinger HW, Cook K, Kamps D, Glass NR, Belzer FO. Clinical and experimental experience with pancreaticocystostomy for exocrine pancreatic drainage in pancreas transplantation. Transplant Proc 1984; 16: 749-751.
25. Dubernard JM, Traeger J, Neyra P, Touraine JL, Tranchant D, Blanc-Brunat N. A new method of preparation of segmental pancreatic grafts for transplantation: trials in dogs and in man. Surgery 1978; 84: 633-639.
26. Luzi L, Perseghin G, Regalia E, Sereni LP, Battezzati A, Baratti D, et al. Metabolic effects of liver transplantation in cirrhotic patients. J Clin Invest 1997; 99: 692-700.
27. Schmidt FH. Die enzimatische Bestimmung von glucose und fructose nebeneinander. Klin Wschr 1961; 39: 1244.
28. SAS Institute Inc. SAS Statistical Package. Cary, NC: SAS Institute Inc., 1992.
29. Merimee TJ, Tyson JE. Stabilization of plasma glucose during fasting; normal variations in two separate studies. N Engl J Med 1974; 291: 1275-1278.
30. Ahlborg G, Felig P. Lactate and glucose exchange across the forearm, legs, and splanchnic bed during and after prolonged leg exercise. J Clin Invest 1982; 69: 45-54.
31. Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI. Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 1995; 44: 180-184.
32. Fanelli C, Pampanelli S, Epifano L, Rambotti AM, Di Vincenzo A, Modarelli F, et al. Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of rational, intensive insulin therapy in IDDM, Diabetologia 1994; 37: 1265-1276.
33. Dagogo-Jack S, Rattarasarn C, Cryer PE. Reversal of hypoglycemia unawareness, but not defective glucose counterregulation in IDDM. Diabetes 1994; 43: 1426-1434.
34. Robertson RP. Seminars in medicine of the Beth Israel Hospital, Boston: pancreatic and islet transplantation for diabetes - cures or curiosities? [Review; see comments]. N Engl J Med 1992; 327: 1861-1868.
35. Cryer PE. Glucose homeostasis and hypoglycemia. In: Wilson JD, Foster DW, eds. Textbook of Endocrinology, 8th edn. Philadelphia, PA: Saunders, 1992: 1223-1253.
36. Rizza RA, Haymond MW, Verdonk CA, Mandarino LJ, Miles JM, Service FJ, Gerich JE. Pathogenesis of hypoglycemia in insulinoma patients: suppression of hepatic glucose production by insulin. Diabetes 1981; 30: 377-381.
37. Battezzati A, Terruzzi I, Perseghin G, Bianchi E, Di Carlo V, Pozza G, Luzi L. Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma. Diabetes 1995; 44: 837-844.
38. Luzi L, Hering BJ, Socci C, Raptis G, Battezzati A, Terruzzi I, et al. Metabolic effects of successful intraportal islet transplantation in IDDM. J Clin Invest 1996; 97: 2611-2618.
39. Luzi L, Battezzati A, Perseghin G, Bianchi E, Vergani S, Secchi A, et al. Lack of feedback inhibition of insulin secretion in denervated human pancreas. Diabetes 1992; 41: 1632-1639.
40. Heller SR, Cryer PE. Hypoinsulinemia is not critical to glucose recovery from hypoglycemia in humans. Am J Physiol 1991; 261: E41-E48.
41. Tran MP, Larsen JL, Duckworth WC, Ruby EJ, Miller SA, Frisbie K, et al. Anti-insulin antibodies are a cause of hypoglycemia following pancreas transplantation. Diabetes Care 1994; 17: 988-993.
42. Benedini S, Calori G, Caldara R, Mazzaferro V, Elli A, Secchi A, et al. Spontaneous hypoglycemia affects IDDM after kidney-pancreas transplant and is not experienced by non-diabetic transplant recipients. Diabetes 1998; 47 (suppl 1): A75.
43. Groth CG, Lundgren G, Ostman J, Gunnarsson R. Experience with nine segmental pancreatic transplantations in preuremic diabetic patients in Stockholm. Transplant Proc 1980; 12: 68-71.
44. Sutherland DE, Moudry KC, Elick BA, Goetz FC, Najarian JS. Pancreas transplant protocols at the University of Minnesota: recipient and donor selection, operative and postoperative management, and outcome. Clin Transplants 1987; 109-126.